Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model
Non-gestational choriocarcinoma (NGC) is a rare subtype of malignant germ cell tumour and there is no consensus on its treatment. The lack of suitable preclinical models for NGC is a challenge in drug discover... (Source: BMC Cancer)
Source: BMC Cancer - November 13, 2023 Category: Cancer & Oncology Authors: Yukari Oda, Kaoru Niimi, Kosuke Yoshida, Satoshi Tamauchi, Akira Yokoi, Yuko Yasui, Yuki Nishiko, Mayu Shibata, Yusuke Shimizu, Masato Yoshihara, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kimihiro Nishino, Eiko Yamamoto and Hiroaki Kajiyama Tags: Research Source Type: research
Case Report: a rare primary gastric choriocarcinoma revealed on 18F-FDG PET/CT
Choriocarcinoma is an exceptionally aggressive trophoblastic cell tumor that that typically originates in gonadal tissues, with rare occurrences outside the gonads, including the mediastinum, retroperitoneum, and intracranial sites. However, it rarely occurs in the stomach. Herein, we presented a case of primary gastric choriocarcinoma in a 27-year-old female patient who found multiple liver masses detected during physical examination, accompanied by remarkably elevated human chorionic gonadotropin levels. The 18F-FDG PET/CT scan suggested ring-shaped intense uptake masses located in the gastric sinus and liver, and no sig...
Source: Frontiers in Oncology - November 10, 2023 Category: Cancer & Oncology Source Type: research
Bisphenol A and its analogue bisphenol S exposure reduce estradiol synthesis via the ROS-mediated PERK/ATF4 signaling pathway
In this study. Elisa assay revealed that both BPA/BPS exposures decreased E2 synthesis in JEG-3 cells. The results of RT-PCR showed that both BPA and BPS could reduce the mRNA expression of CYP19A1, a key enzyme for E2 synthesis in JEG-3 cells. In addition, Western blot assay showed that BPA/BPS-induced ER-stress PERK/eIF2α/ATF4 signaling protein expression was increased. The expression of ROS in cells after exposure to BPA/BPS was detected using the 2,7-dichlorodihydrofluorescein diacetate (DCF-DA) method. The results of this experiment showed that BPA/BPS significantly induced an inhibition of ROS in JEG-3 cells. The pr...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Zhou Li Chen Chen Pan Ying Gu Ji-Jun Dou Lian-Jie Huang Dan Zou Xuan-Min Guan Tian-Yue Zhang Chao Hao Jia-Hu Source Type: research
Bisphenol A and its analogue bisphenol S exposure reduce estradiol synthesis via the ROS-mediated PERK/ATF4 signaling pathway
In this study. Elisa assay revealed that both BPA/BPS exposures decreased E2 synthesis in JEG-3 cells. The results of RT-PCR showed that both BPA and BPS could reduce the mRNA expression of CYP19A1, a key enzyme for E2 synthesis in JEG-3 cells. In addition, Western blot assay showed that BPA/BPS-induced ER-stress PERK/eIF2α/ATF4 signaling protein expression was increased. The expression of ROS in cells after exposure to BPA/BPS was detected using the 2,7-dichlorodihydrofluorescein diacetate (DCF-DA) method. The results of this experiment showed that BPA/BPS significantly induced an inhibition of ROS in JEG-3 cells. The pr...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Zhou Li Chen Chen Pan Ying Gu Ji-Jun Dou Lian-Jie Huang Dan Zou Xuan-Min Guan Tian-Yue Zhang Chao Hao Jia-Hu Source Type: research
Bisphenol A and its analogue bisphenol S exposure reduce estradiol synthesis via the ROS-mediated PERK/ATF4 signaling pathway
In this study. Elisa assay revealed that both BPA/BPS exposures decreased E2 synthesis in JEG-3 cells. The results of RT-PCR showed that both BPA and BPS could reduce the mRNA expression of CYP19A1, a key enzyme for E2 synthesis in JEG-3 cells. In addition, Western blot assay showed that BPA/BPS-induced ER-stress PERK/eIF2α/ATF4 signaling protein expression was increased. The expression of ROS in cells after exposure to BPA/BPS was detected using the 2,7-dichlorodihydrofluorescein diacetate (DCF-DA) method. The results of this experiment showed that BPA/BPS significantly induced an inhibition of ROS in JEG-3 cells. The pr...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Zhou Li Chen Chen Pan Ying Gu Ji-Jun Dou Lian-Jie Huang Dan Zou Xuan-Min Guan Tian-Yue Zhang Chao Hao Jia-Hu Source Type: research
A decade in focus: mixed germ cell tumors with choriocarcinoma components
CONCLUSION: Mixed germ cell tumours with choriocarcinoma components are rare and tend to affect younger populations. These tumours demonstrate aggressive clinical behaviour, with a significant proportion presenting with high-grade lesions and metastasis at diagnosis. The observed mortality rate underscores the poor prognosis associated with this malignancy. Our study provides essential insights into the clinical characteristics of this rare tumour subtype in the Saudi Arabian population, emphasizing the need for further research to identify prognostic factors and optimize management strategies for affected patients.PMID:37...
Source: Annals of Medicine - November 2, 2023 Category: Internal Medicine Authors: Abdullah Al-Khayal Yasser Noureldin Mohammad Alghafees Areez Shafqat Belal Nedal Sabbah Asem H Elhossiny Mohamad Bakir Mohammed Ali Omar Tarek Ziad Arabi Saleha Abdul Rab Bader Alsaikhan Reema Aldhalaan Muhannad Alquirnas Khalid Alrabeeah Source Type: research
A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in patients with gestational trophoblastic neoplasia
CONCLUSIONS: Ipilimumab plus nivolumab demonstrated efficacy in chemotherapy-refractory GTN, an ultra-rare cancer affecting young women. Three out of four patients achieved ongoing objective responses with a reasonable safety profile at 6-11+ months.PMID:37882676 | DOI:10.1158/1078-0432.CCR-23-2293 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 26, 2023 Category: Cancer & Oncology Authors: Sandip P Patel Megan Othus Young Kwang Chae Michael J Dennis Sarah Gordon David Mutch Wolfram Samlowski William R Robinson Elad Sharon Christopher Ryan Gabby Lopez Melissa Plets Charles Blanke Razelle Kurzrock Source Type: research
A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in patients with gestational trophoblastic neoplasia
CONCLUSIONS: Ipilimumab plus nivolumab demonstrated efficacy in chemotherapy-refractory GTN, an ultra-rare cancer affecting young women. Three out of four patients achieved ongoing objective responses with a reasonable safety profile at 6-11+ months.PMID:37882676 | DOI:10.1158/1078-0432.CCR-23-2293 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 26, 2023 Category: Cancer & Oncology Authors: Sandip P Patel Megan Othus Young Kwang Chae Michael J Dennis Sarah Gordon David Mutch Wolfram Samlowski William R Robinson Elad Sharon Christopher Ryan Gabby Lopez Melissa Plets Charles Blanke Razelle Kurzrock Source Type: research
A rare case of pulmonary artery embolism with choriocarcinoma: A case report and literature review
Oncol Lett. 2023 Sep 28;26(5):490. doi: 10.3892/ol.2023.14077. eCollection 2023 Nov.ABSTRACTPulmonary embolism (PE) caused by malignant tumor is not uncommon, but pulmonary artery with choriocarcinoma is rare and difficult to timely diagnose and effectively treat. To the best of our knowledge, there are only 15 cases reported at present in the literature that present variable clinical characteristics and prognosis. In the current study reports a 21-year-old female with a history of chest pain and slight fever for 4 months who was treated as a case of pneumonia. Owing to the recurrence of the symptoms, a contrast-enhanced c...
Source: Oncology Letters - October 19, 2023 Category: Cancer & Oncology Authors: Pengcheng Wang Dunqiang Ren Caihong Guo Xiaoqian Ding Yiwei Cao Peige Zhao Qiang Wang Wenjuan Xu Source Type: research
