Gestational choriocarcinoma with pulmonary and cerebral metastasis mimicking pulmonary tuberculosis: A case report
Asian J Surg. 2023 Dec 1:S1015-9584(23)01797-9. doi: 10.1016/j.asjsur.2023.11.062. Online ahead of print.NO ABSTRACTPMID:38042655 | DOI:10.1016/j.asjsur.2023.11.062 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 2, 2023 Category: Surgery Authors: Lingyun Yang Qianrun Chen Ce Bian Source Type: research
Quantification of Trophoblast Syncytialization by Fluorescent Membrane Labeling
Methods Mol Biol. 2024;2728:99-104. doi: 10.1007/978-1-0716-3495-0_8.ABSTRACTTrophoblast fusion or syncytialization is a fundamental yet poorly understood process during placental development. Primary cultured cytotrophoblasts and human choriocarcinoma cell lines are commonly used to study trophoblast fusion mechanisms in vitro. Quantification of trophoblast fusion index is a key for the in vitro studies. In this chapter, we describe a new method to quantify fusion index, which is based on fluorescent labeling of the plasma membrane using Di-8-ANEPPS, a membrane potential dye. This method directly works on live cells, ther...
Source: Mol Biol Cell - November 29, 2023 Category: Molecular Biology Authors: Yang Zhang Huanghe Yang Source Type: research
In Vivo Quantitative Assessment of Gestational Choriocarcinoma Development and Progression Using Luminescent Trophoblast Cells
Methods Mol Biol. 2024;2728:77-85. doi: 10.1007/978-1-0716-3495-0_6.ABSTRACTGestational trophoblastic diseases (GTD) are a group of pregnancy-related disorders representing rare human tumors. Among GTD is the gestational choriocarcinoma (CC), which is a highly malignant gestational trophoblastic tumor that causes high mortality without timely treatment. The incidence of CC is about 1 in 50,000 pregnancies in developed countries and even higher in developing countries. CC developed from molar pregnancies exhibits even higher incidence rates (3-20 in 1000 pregnancies). In the present invention, we developed the first orthoto...
Source: Mol Biol Cell - November 29, 2023 Category: Molecular Biology Authors: Wael Traboulsi Deborah Reynaud Roland Abi Nahed Fr édéric Sergent Nadia Alfaidy Mohamed Benharouga Source Type: research
Quantification of Trophoblast Syncytialization by Fluorescent Membrane Labeling
Methods Mol Biol. 2024;2728:99-104. doi: 10.1007/978-1-0716-3495-0_8.ABSTRACTTrophoblast fusion or syncytialization is a fundamental yet poorly understood process during placental development. Primary cultured cytotrophoblasts and human choriocarcinoma cell lines are commonly used to study trophoblast fusion mechanisms in vitro. Quantification of trophoblast fusion index is a key for the in vitro studies. In this chapter, we describe a new method to quantify fusion index, which is based on fluorescent labeling of the plasma membrane using Di-8-ANEPPS, a membrane potential dye. This method directly works on live cells, ther...
Source: Mol Biol Cell - November 29, 2023 Category: Molecular Biology Authors: Yang Zhang Huanghe Yang Source Type: research
In Vivo Quantitative Assessment of Gestational Choriocarcinoma Development and Progression Using Luminescent Trophoblast Cells
Methods Mol Biol. 2024;2728:77-85. doi: 10.1007/978-1-0716-3495-0_6.ABSTRACTGestational trophoblastic diseases (GTD) are a group of pregnancy-related disorders representing rare human tumors. Among GTD is the gestational choriocarcinoma (CC), which is a highly malignant gestational trophoblastic tumor that causes high mortality without timely treatment. The incidence of CC is about 1 in 50,000 pregnancies in developed countries and even higher in developing countries. CC developed from molar pregnancies exhibits even higher incidence rates (3-20 in 1000 pregnancies). In the present invention, we developed the first orthoto...
Source: Mol Biol Cell - November 29, 2023 Category: Molecular Biology Authors: Wael Traboulsi Deborah Reynaud Roland Abi Nahed Fr édéric Sergent Nadia Alfaidy Mohamed Benharouga Source Type: research
Rare non-serous fallopian tube cancers: institutional experience and literature review
ConclusionRare non-serous malignant fallopian tube tumors are very similar to serous and endometrioid FTC in terms of clinical manifestations and diagnosis. (Source: Wiener Medizinische Wochenschrift)
Source: Wiener Medizinische Wochenschrift - November 28, 2023 Category: General Medicine Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions
CONCLUSIONS.—: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called "chorangiocarcinoma" and chorangioma with atyp...
Source: Archives of Pathology and Laboratory Medicine - November 17, 2023 Category: Laboratory Medicine Authors: Julia Dahl Source Type: research
