Management of chordoma and chondrosarcoma with definitive dose-escalated single-fraction spine stereotactic radiosurgery
CONCLUSION: Definitive dose-escalated SSRS to 24 Gy in 1 fraction appears to be a safe and effective treatment for achieving durable local control in chordoma or chondrosarcoma involving the spine, and may hold particular importance as a low-morbidity alternative to surgery in selected cases.PMID:37667065 | DOI:10.1007/s11060-023-04432-1 (Source: Cancer Control)
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Alexander D Sherry Sean Maroongroge Brian De Behrang Amini Anthony P Conley Andrew J Bishop Chenyang Wang Thomas Beckham Martin Tom Tina Briere Jing Li Debra N Yeboa Mary Frances McAleer Robert North Claudio E Tatsui Laurence D Rhines Amol J Ghia Source Type: research
Cervicothoracic chordoma: A case report and literature review
Asian J Surg. 2023 Sep 1:S1015-9584(23)01353-2. doi: 10.1016/j.asjsur.2023.08.169. Online ahead of print.NO ABSTRACTPMID:37661482 | DOI:10.1016/j.asjsur.2023.08.169 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 4, 2023 Category: Surgery Authors: Yuqin Qiu Beichuan Pang Jiang Hu Kun Zhang Source Type: research
Management of chordoma and chondrosarcoma with definitive dose-escalated single-fraction spine stereotactic radiosurgery
ConclusionDefinitive dose-escalated SSRS to 24 Gy in 1 fraction appears to be a safe and effective treatment for achieving durable local control in chordoma or chondrosarcoma involving the spine, and may hold particular importance as a low-morbidity alternative to surgery in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research
Predicting overall survival in chordoma patients using machine learning models: a web-app application
The goal of this study was to evaluate the efficacy of machine learning (ML) techniques in predicting survival for chordoma patients in comparison with the standard Cox proportional hazards (CoxPH) model. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - September 2, 2023 Category: Orthopaedics Authors: Peng Cheng, Xudong Xie, Samuel Knoedler, Bobin Mi and Guohui Liu Tags: Research article Source Type: research
The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies
Chordoma is a rare malignant bone tumor with limited therapeutic options, which is resistant to conventional chemotherapy and radiotherapy, and targeted therapy is also shown with little efficacy. The long-standing delay in researching its mechanisms of occurrence and development has resulted in the dilemma of no effective treatment targets and no available drugs in clinical practice. In recent years, the role of the tumor immune microenvironment in driving tumor growth has become a hot and challenging topic in the field of cancer research. Immunotherapy has shown promising results in the treatment of various tumors. Howev...
Source: Frontiers in Immunology - September 1, 2023 Category: Allergy & Immunology Source Type: research
A rare case of skin metastasis from a chordoma
Chordoma is an uncommon, indolent malignant tumor arising from notochordal remnants. The incidence of distant metastasis varies between 30 and 40% in different series. Even though local involvement of the skin by direct invasion of chordoma is common, distant skin metastasis are rare, with less than 30 cases reported in the literature. The present clinical case illustrates the slow-growing natural history of a sacral chordoma, which evolved with lung metastasis, followed three years later by skin metastasis, thus giving us the opportunity to review the diagnostic approach, as well as the clinical and histopathological char...
Source: Dermatology Online Journal - August 31, 2023 Category: Dermatology Authors: Vaz Cunha, Maria Source Type: research
Shedding light on emerging therapeutic targets for chordoma
. (Source: Expert Opinion on Therapeutic Targets)
Source: Expert Opinion on Therapeutic Targets - August 30, 2023 Category: Drugs & Pharmacology Authors: Margot Martinez Moreno Elaina Wang Christian Schroeder Patricia Sullivan Ziya Gokaslan Source Type: research
Percutaneous spine biopsy: reaching those hard-to-reach places
AbstractCancer is a leading cause of death, with the spine being the most common site for skeletal metastasis. The spine is also a site for primary malignancy, such as sarcoma and chordoma, as well as non-neoplastic pathologies. An accurate diagnosis of spinal neoplastic diseases is crucial in determining appropriate management. With the advent of personalised oncology, the need to establish a definitive histopathologic diagnosis to guide management is more important than ever. Percutaneous biopsy has proven to be safe and efficient in establishing a reliable histopathologic diagnosis. The spine, however, can be a chall...
Source: Skeletal Radiology - August 24, 2023 Category: Radiology Source Type: research
Poorly differentiated extra-axial extraskeletal chordoma diagnosed by methylation profiling: case report and analysis of brachyury expression in SWI/SNF-deficient tumors
We report a case of a high-grade epithelioid tumor involving the synovium and soft tissues of the knee in a 74-year-old male patient. The preliminary biopsy was inconclusive, but a diagnosis of metastatic clear-cell carcinoma of unknown origin was suggested. However, imaging studies did not reveal any primary lesions. The resection specimen consisted of nests and sheets of oval to polygonal cells with discernible cell borders, clear or lightly amphophilic cytoplasm, and round to oval nuclei with occasional well-visible eosinophilic nucleoli. Rare atypical mitoses, necrotic areas, and bizarre nuclei were noted. The biopsy a...
Source: Virchows Archiv - August 18, 2023 Category: Pathology Source Type: research
Glomus coccygeum masquerading as chordoma
Can J Neurol Sci. 2023 Aug 14:1-4. doi: 10.1017/cjn.2023.273. Online ahead of print.NO ABSTRACTPMID:37577953 | DOI:10.1017/cjn.2023.273 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - August 14, 2023 Category: Neurology Authors: Bryan J Neth Hamed R Youshanlouei Andrew L Folpe Michelle J Clarke Ugur Sener Source Type: research
Glomus coccygeum masquerading as chordoma
Can J Neurol Sci. 2023 Aug 14:1-4. doi: 10.1017/cjn.2023.273. Online ahead of print.NO ABSTRACTPMID:37577953 | DOI:10.1017/cjn.2023.273 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - August 14, 2023 Category: Neurology Authors: Bryan J Neth Hamed R Youshanlouei Andrew L Folpe Michelle J Clarke Ugur Sener Source Type: research
Glomus coccygeum masquerading as chordoma
Can J Neurol Sci. 2023 Aug 14:1-4. doi: 10.1017/cjn.2023.273. Online ahead of print.NO ABSTRACTPMID:37577953 | DOI:10.1017/cjn.2023.273 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - August 14, 2023 Category: Neurology Authors: Bryan J Neth Hamed R Youshanlouei Andrew L Folpe Michelle J Clarke Ugur Sener Source Type: research
Glomus coccygeum masquerading as chordoma
Can J Neurol Sci. 2023 Aug 14:1-4. doi: 10.1017/cjn.2023.273. Online ahead of print.NO ABSTRACTPMID:37577953 | DOI:10.1017/cjn.2023.273 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - August 14, 2023 Category: Neurology Authors: Bryan J Neth Hamed R Youshanlouei Andrew L Folpe Michelle J Clarke Ugur Sener Source Type: research
Radiotherapy in bone sarcoma: the quest for better treatment option
Bone sarcomas are rare tumors representing 0.2% of all cancers. While osteosarcoma and Ewing sarcoma mainly affect children and young adults, chondrosarcoma and chordoma have a preferential incidence in people... (Source: BMC Cancer)
Source: BMC Cancer - August 11, 2023 Category: Cancer & Oncology Authors: Marie-Ana ïs Locquet, Mehdi Brahmi, Jean-Yves Blay and Aurélie Dutour Tags: Review Source Type: research
Bilateral Inferior Turbinate Flaps for Salvage Reconstruction after Proton Beam Radiotherapy for Clival Chordoma
We describe successful skull base reconstruction with intranasal bilateral inferior turbinate flaps based on the sphenopalatine artery with lateral nasal wall extension, despite prior proton beam therapy and a failed prior vascularized intranasal reconstruction. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Journal of Neurological Surgery Reports)
Source: Journal of Neurological Surgery Reports - August 11, 2023 Category: Neurosurgery Authors: Crawford, Kayva L. Saripella, Megana DeConde, Adam S. Beaumont, Thomas L. Tags: Original Report Source Type: research
