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Chordoma cells possess bone-dissolving activity at the bone invasion front
ConclusionIn chordoma, we propose that in addition to conventional bone resorption by osteoclasts, chordoma cells possess bone-dissolving activity at the tumor-bone boundary. Furthermore, bone destruction and tumor expansion may occur in a positive feedback loop. (Source: Cellular Oncology)
Source: Cellular Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

MicroRNA ‑1224 inhibits cell proliferation by downregulating CBX3 expression in chordoma
Oncol Lett. 2024 Apr 10;27(6):262. doi: 10.3892/ol.2024.14395. eCollection 2024 Jun.ABSTRACTMicroRNAs (miRNAs/miRs) have abnormal expression in numerous tumors and are closely related to tumor development and resistance to radiotherapy and chemotherapy. However, there are few studies assessing the role and mechanism of miRNA in chordoma. The sequencing data of three pairs of chordoma and notochord tissues from the GSE56183 dataset were analyzed in the present study. Cell proliferation was assessed in vitro using Cell Counting Kit-8. Bioinformatics analysis and the dual luciferase reporter assay were used to evaluate the re...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Wei Xia Jihe Huang Chunhua Sun Fei Shen Kejia Yang Source Type: research

Biological dose optimization incorporating intra-tumoural cellular radiosensitivity heterogeneity in ion-beam therapy treatment planning
Phys Med Biol. 2024 Apr 18. doi: 10.1088/1361-6560/ad4085. Online ahead of print.ABSTRACTTreatment plans of charged-particle therapy have been made under an assumption that all cancer cells within a tumour equally respond to a given radiation. However, an intra-tumoural cellular radiosensitivity heterogeneity clearly exists, and it may lead to an overestimation of therapeutic effects of the radiation. The purpose of this study was to develop a biological model that can incorporate the radiosensitivity heterogeneity into biological optimization for charged-particle therapy treatment planning.Approach. The ...
Source: Physics in Medicine and Biology - April 18, 2024 Category: Physics Authors: Taku Inaniwa Nobuyuki Kanematsu Masashi Koto Source Type: research

Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma
British Journal of Cancer, Published online: 11 April 2024; doi:10.1038/s41416-024-02635-5Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Huantong Wu Xinqiang Li Boyan Zhang Penghao Liu Maoyang Qi Yueqi Du Can Zhang Wanru Duan Zan Chen Source Type: research

Cancers, Vol. 16, Pages 1284: Sacral-Nerve-Sparing Planning Strategy in Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy
Piero Fossati To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (LEM-I), prescribed DRBE|LEM-I|D50% (median dose to HD-PTV) = 73.6 (70.4&ndash;76.8) Gy (RBE)/16 fractions. Sacral nerves were contoured between L5-S3 levels. DRBE|LEM-I to 5% of sacral nerves-to-spare (outside HD-CTV) (DRBE|LEM-I|D5%) were restricted to &lt;69 Gy (RBE). The median follow-up was 25 months (range of 2&ndash;53). Three pa...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Ankita Nachankar Mansure Schafasand Eugen Hug Giovanna Martino Joanna G óra Antonio Carlino Markus Stock Piero Fossati Tags: Article Source Type: research

SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc
This study was performed to in... (Source: BMC Cancer)
Source: BMC Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Minghui Jiang, Zheng Huang, Li Chen, Ting Deng, Junpeng Liu and Yue Wu Tags: Research Source Type: research

Complications and local recurrence of chondrosarcoma and chordoma treated by total tumor resection in thoracic and lumbar spine
En bloc resection of spinal tumors is challenging and associated with a high incidence of complications; however, it offers the potential to reduce the risk of recurrence when a wide margin is achieved. This r... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - March 26, 2024 Category: Orthopaedics Authors: Jiacheng Liu, Panpan Hu, Zhongjun Liu and Feng Wei Tags: Research Source Type: research

Retraction. Immunohistochemical markers predicting recurrence following resection and radiotherapy in chordoma patients: insights from a multicenter study
J Neurosurg. 2024 Mar 22:1. doi: 10.3171/2024.2.JNS23862r. Online ahead of print.NO ABSTRACTPMID:38518293 | DOI:10.3171/2024.2.JNS23862r (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Carlos Pinheiro Neto Mohamad Bydon Source Type: research

Successful resection of giant sacrococcygeal chordoma through anterior and posterior combined approach
Asian J Surg. 2024 Mar 21:S1015-9584(24)00444-5. doi: 10.1016/j.asjsur.2024.03.018. Online ahead of print.NO ABSTRACTPMID:38519318 | DOI:10.1016/j.asjsur.2024.03.018 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 22, 2024 Category: Surgery Authors: Zhicheng Xiang Taixian Cao Qi Yang Qiang Zhang Source Type: research