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Electromyographic predictors of abducens nerve palsy after endoscopic skull base surgery
CONCLUSIONS: The presence of f-EMG activity, lack of CMAP response to stimulation, decreased CMAP amplitude, and increased CMAP onset latency were associated with immediately postoperative ANP. Long-term ANP outcomes may be associated with t-EMG parameters, including whether the nerve is able to be stimulated once identified and CMAP amplitude. Future prospective studies may be designed to standardize abducens nerve electrophysiological monitoring protocols to further refine operative and prognostic utility.PMID:38157534 | DOI:10.3171/2023.10.JNS23648 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - December 29, 2023 Category: Neurosurgery Authors: Joaquin E Jimenez Mahmoud Omar Gregory M Adams Tina Costacou Parthasarathy D Thirumala Donald J Crammond Katherine M Anetakis Jeffrey R Balzer Varun Shandal Carl H Snyderman Paul A Gardner Georgios A Zenonos Eric W Wang Source Type: research

Paraspinal cervical chordoma
Br J Hosp Med (Lond). 2023 Dec 2;84(12):1. doi: 10.12968/hmed.2023.0285. Epub 2023 Dec 27.NO ABSTRACTPMID:38153021 | DOI:10.12968/hmed.2023.0285 (Source: British Journal of Hospital Medicine)
Source: British Journal of Hospital Medicine - December 28, 2023 Category: Internal Medicine Authors: G ökhan Tonkaz Ahmet Yasin Yitik Mehmet Tonkaz Duygu Erkal Tonkaz Recep Sade Source Type: research

Cancers, Vol. 15, Pages 5800: Chordoma: A Comprehensive Systematic Review of Clinical Trials
Sean P. Polster This systematic review aims to characterize ongoing clinical trials and therapeutic treatment options for chordoma, a rare notochordal remnant tumor that primarily affects the cranial base, mobile spine, and sacrum. While radical surgical resection remains the cornerstone for chordoma management, unique technical challenges posed by its proximity to critical neurovascular structures confer a tendency towards disease recurrence which often requires additional treatment modalities. In an attempt to better understand the current treatment landscape, a systematic review was designed to identify clinical tri...
Source: Cancers - December 11, 2023 Category: Cancer & Oncology Authors: Sonja Chen Ruben Ulloa Justin Soffer Roberto J. Alcazar-Felix Carl H. Snyderman Paul A. Gardner Vijay A. Patel Sean P. Polster Tags: Review Source Type: research

Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
CONCLUSIONS: High-dose pemetrexed appears tolerable and shows objective antitumor activity in patients with chordoma. Phase II studies of high-dose pemetrexed are warranted.PMID:38047868 | DOI:10.1158/1078-0432.CCR-23-2317 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - December 4, 2023 Category: Cancer & Oncology Authors: Santosh Kesari Naveed Wagle Jose A Carrillo Akanksha Sharma Minhdan Nguyen Judy Truong Jaya M Gill Raffi Nersesian Natsuko Nomura Elnaz Rahbarlayegh Garni Barkhoudarian Walavan Sivakumar Daniel F Kelly Howard Krauss Matias A Bustos Dave S B Hoon Lars Anke Source Type: research

Outcomes of the Endoscopic Endonasal Approach for the Treatment of Clival Chordomas: A Single-Center Experience
Conclusion This series demonstrates that expanded endoscopic endonasal approach (EEA) for the resection of skull base chordomas, followed by CyberKnife radiosurgery, presents a viable alternative to proton beam therapy; however, further research is necessary to directly compare these modalities. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - December 4, 2023 Category: Neurosurgery Authors: Alsayed, Ahmed Alrasheed, Abdulaziz S. Aljabab, Saif Alshareef, Mohammad Yahya, Buthaina Jaber Alharbi, Abdulmajeed Alroqi, Ahmad Albaharna, Hussain Alromaih, Saud Alayed, Yasir Alqurashi, Ashwag Alsaleh, Saad Ajlan, Abdulrazag Tags: Original Article Source Type: research