Cancers, Vol. 15, Pages 5800: Chordoma: A Comprehensive Systematic Review of Clinical Trials

Cancers, Vol. 15, Pages 5800: Chordoma: A Comprehensive Systematic Review of Clinical Trials Cancers doi: 10.3390/cancers15245800 Authors: Sonja Chen Ruben Ulloa Justin Soffer Roberto J. Alcazar-Felix Carl H. Snyderman Paul A. Gardner Vijay A. Patel Sean P. Polster This systematic review aims to characterize ongoing clinical trials and therapeutic treatment options for chordoma, a rare notochordal remnant tumor that primarily affects the cranial base, mobile spine, and sacrum. While radical surgical resection remains the cornerstone for chordoma management, unique technical challenges posed by its proximity to critical neurovascular structures confer a tendency towards disease recurrence which often requires additional treatment modalities. In an attempt to better understand the current treatment landscape, a systematic review was designed to identify clinical trials directed at chordoma. A total of 108 chordoma trials were identified from four clinical trial databases; fifty-one trials were included in the final analysis, of which only 14 were designated as completed (27.5%). Aggregate data suggests most chordoma interventions are repurposed from other neoplasms that share common molecular pathways, with a recent emphasis on combination therapeutics within and across drug classes. Naturally, the publication and dissemination of clinical trial results remain a concern (n = 4, 28.6%), highlighting the need for enhanced reporting and transparency measures....
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research