Nicotine abuse and neurodegeneration: Novel pharmacogenetic targets to aid quitting and reduce the risk of dementia
CNS Neurol Disord Drug Targets. 2023 Feb 20. doi: 10.2174/1871527322666230220121655. Online ahead of print.ABSTRACTNicotine dependence has deleterious neurological impacts. Previous studies found an association between cigarette smoking and accelerating age-related thinning of the brain's cortex and subsequent cognitive decline. Smoking is considered the third most common risk factor for dementia, which prompted the inclusion of smoking cessation in dementia prevention strategies. Traditional pharmacologic options for smoking cessation include nicotine transdermal patches, bupropion and varenicline. However, based on smoke...
Source: CNS and Neurological Disorders Drug Targets - February 21, 2023 Category: Drugs & Pharmacology Authors: Fatimah Almahasneh Romany Gerges Ejlal Abu-El-Rub Ramada Khasawneh Source Type: research
Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia
CNS Neurol Disord Drug Targets. 2023 Feb 20. doi: 10.2174/1871527322666230220121655. Online ahead of print.ABSTRACTNicotine dependence has deleterious neurological impacts. Previous studies found an association between cigarette smoking and accelerating age-related thinning of the brain's cortex and subsequent cognitive decline. Smoking is considered the third most common risk factor for dementia, which prompted the inclusion of smoking cessation in dementia prevention strategies. Traditional pharmacologic options for smoking cessation include nicotine transdermal patches, bupropion and varenicline. However, based on smoke...
Source: CNS and Neurological Disorders Drug Targets - February 21, 2023 Category: Drugs & Pharmacology Authors: Fatimah Almahasneh Romany H. Gerges Ejlal Abu-El-Rub Ramada R. Khasawneh Source Type: research
Varenicline-induced drug eruption: case and review of the literature
We report this case since we believe no drug reaction to varenicline has had this clinical presentation or rapidity of onset. Clinicians should be aware of this potential adverse cutaneous reaction in patients taking varenicline for smoking cessation. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - February 16, 2023 Category: Dermatology Authors: Correia, Catarina Source Type: research
Bilateral Effect of OC-01 (Varenicline Solution) Nasal Spray for Treatment of Signs and Symptoms in Individuals with Mild, Moderate, and Severe Dry Eye Disease
This study compares outcomes of therapy with OC-01 (varenicline solution) for dry eye disease in study eyes and nonstudy fellow eyes of participants in 2 pivotal clinical trials.METHODS: All 891 patients randomized to receive OC-01 (varenicline solution) 0.03 mg, OC-01 (varenicline solution) 0.06 mg, or vehicle control (VC) in each nostril twice daily for 28 days in the Phase IIb ONSET-1 (Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease) and Phase III ONSET-2 trials were included in this post hoc analysis. One eye was designated as the study eye. The mean change from baseline in anes...
Source: Clinical Therapeutics - February 10, 2023 Category: Drugs & Pharmacology Authors: James Katz Laura M Periman Sathi Maiti Enrica Sarnicola Mandy Hemphill Alan G Kabat Laura H Hendrix Puja Shah Andrea Gibson Source Type: research
Bilateral Effect of OC-01 (Varenicline Solution) Nasal Spray for Treatment of Signs and Symptoms in Individuals with Mild, Moderate, and Severe Dry Eye Disease
This study compares outcomes of therapy with OC-01 (varenicline solution) for dry eye disease in study eyes and nonstudy fellow eyes of participants in 2 pivotal clinical trials.METHODS: All 891 patients randomized to receive OC-01 (varenicline solution) 0.03 mg, OC-01 (varenicline solution) 0.06 mg, or vehicle control (VC) in each nostril twice daily for 28 days in the Phase IIb ONSET-1 (Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease) and Phase III ONSET-2 trials were included in this post hoc analysis. One eye was designated as the study eye. The mean change from baseline in anes...
Source: Clinical Therapeutics - February 10, 2023 Category: Drugs & Pharmacology Authors: James Katz Laura M Periman Sathi Maiti Enrica Sarnicola Mandy Hemphill Alan G Kabat Laura H Hendrix Puja Shah Andrea Gibson Source Type: research
IJERPH, Vol. 20, Pages 1870: Medications for the Treatment of Alcohol Dependence & mdash;Current State of Knowledge and Future Perspectives from a Public Health Perspective
IJERPH, Vol. 20, Pages 1870: Medications for the Treatment of Alcohol Dependence—Current State of Knowledge and Future Perspectives from a Public Health Perspective
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph20031870
Authors:
Iga Stokłosa
Gniewko Więckiewicz
Maciej Stokłosa
Magdalena Piegza
Robert Pudlo
Piotr Gorczyca
No single effective therapy for alcohol abuse has been found, despite it being a serious sociological and economic problem for hundreds of years. It seems difficult to find a single drug as a panacea for the alcohol problem due to the co...
Source: International Journal of Environmental Research and Public Health - January 19, 2023 Category: Environmental Health Authors: Iga Stok łosa Gniewko Wi ęckiewicz Maciej Stok łosa Magdalena Piegza Robert Pudlo Piotr Gorczyca Tags: Review Source Type: research
Varenicline induced auditory hallucinations in a young female with bipolar disorder: a case report
Creating appropriate and sustainable treatment plans for patients with concurrent disorders presents a challenge to psychiatrists and addiction medicine specialists alike. Although varenicline has been found t... (Source: BMC Psychiatry)
Source: BMC Psychiatry - January 3, 2023 Category: Psychiatry Authors: Vivian W. L. Tsang, Saundarai Bhanot and Lingsa Jia Tags: Case report Source Type: research
Transcranial direct current stimulation (tDCS) therapy combined with varenicline to improve smoking cessation outcomes: a proof-of-concept double-blind sham-controlled trial
Abstract (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 1, 2023 Category: Neurology Authors: Helena Zhang, Tarek Rajji, Peter Selby, Osnat Melamed, Laurie Zawertailo Source Type: research
Smoking quit rates among patients receiving pharmacotherapy who received general practitioner counselling versus intensive counselling: a retrospective cohort study
CONCLUSION: We did not detect a statistically significant difference in smoking quit rates, though there was a trend towards higher quit rates with intensive counselling.PMID:36575392 | PMC:PMC9793508 | DOI:10.1186/s12875-022-01953-y (Source: Primary Care)
Source: Primary Care - December 27, 2022 Category: Primary Care Authors: Ilan Yehoshua Limor Adler Sharon Alon Hermoni Miri Mizrahi Reuveni Avital Bilitzky Keren Oren Galia Zacay Source Type: research
Smoking quit rates among patients receiving pharmacotherapy who received general practitioner counselling versus intensive counselling: a retrospective cohort study
CONCLUSION: We did not detect a statistically significant difference in smoking quit rates, though there was a trend towards higher quit rates with intensive counselling.PMID:36575392 | PMC:PMC9793508 | DOI:10.1186/s12875-022-01953-y (Source: Primary Care)
Source: Primary Care - December 27, 2022 Category: Primary Care Authors: Ilan Yehoshua Limor Adler Sharon Alon Hermoni Miri Mizrahi Reuveni Avital Bilitzky Keren Oren Galia Zacay Source Type: research
IJERPH, Vol. 19, Pages 17010: Systematic Review of Smoking Cessation Inventions for Smokers Diagnosed with Cancer
cia Fitzpatrick
The detrimental impact of smoking on health and wellbeing are irrefutable. Additionally, smoking is associated with the development of cancer, a reduction treatment outcomes and poorer health outcomes. Nevertheless, a significant number of people continue to smoke following a cancer diagnosis. Little is understood of the smoking cessation services provided to smokers with cancer or their engagement with them. This systematic review aimed to identify existing smoking cessation interventions for this cohort diagnosed with breast, head and neck, lung and cervical cancers (linked to risk). Systematic search...
Source: International Journal of Environmental Research and Public Health - December 18, 2022 Category: Environmental Health Authors: Kate Frazer Nancy Bhardwaj Patricia Fox Diarmuid Stokes Vikram Niranjan Seamus Quinn Cecily C. Kelleher Patricia Fitzpatrick Tags: Systematic Review Source Type: research
Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels
Alcohol Clin Exp Res. 2022 Dec 14. doi: 10.1111/acer.14953. Online ahead of print.NO ABSTRACTPMID:36515648 | DOI:10.1111/acer.14953 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - December 14, 2022 Category: Addiction Authors: Steven J Nieto Craig K Enders Katie Witkiewitz Stephanie S O'Malley Lara A Ray Source Type: research
Varenicline for Tobacco-Dependent Adults Who Are Not Ready to Discontinue Use: A Systematic Review and Meta-Analysis
Annals of the American Thoracic Society,Volume 19, Issue 12, Page 2077-2086, December 2022. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - December 1, 2022 Category: Respiratory Medicine Authors: Luciane Cruz Lopes Yuan Zhang Stephanie Ross Izabela Fulone Meng Zhu Kelly K. O ’Brien Sureka Pavalagantharajah Frank T. Leone David P. L. Sachs Hasmeena Kathuria Rachael L. Murray Yu-Qing Zhang Source Type: research
Smoking cessation program for patients with diabetes-success factors
Smoking in patients with diabetes mellitus (DM) is associated with higher mortality, cardiovascular morbidity and complication rates. Post cessation weight gain and psychologic burden are common distractors from cessation goal. Tailoring interventions for this population could improve cessation rates.We recruited DM patients that consented to participate in an intense program including behavioral support and varenicline (Fig.1a). 64 smokers were informed and 54 accepted to participate. Characteristics shown on Fig.1b. At the end of the program 59.2% quit smoking. Changes of rest metabolism rate (DM 2 only), HbA1c and ...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Korkontzelou, A., Driva, S., Schoretsaniti, S., Barbaressou, Z., Vasileiou, V., Saltagianni, V., Osarogue, A., Gyftopoulos, S., Andritsou, M., Pappa, S., Tonstad, S., Gratziou, C., Tentolouris, N., Katsaounou, P. Tags: 06.03 - Tobacco, smoking control and health education Source Type: research
Educational interventions to improve inpatient smoking cessation support
Discussion: We demonstrated that implementation of face-to-face learning reinforced with online modules coupled with refresher training is valuable in the time pressured environment of junior doctors to ensure effective management of smokers. Moving forward, this will hopefully become a mandatory part of junior doctor training here. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Lyons, A., Walshe, R., Timehin, C., Roy, K. Tags: 06.03 - Tobacco, smoking control and health education Source Type: research
