“The crackers challenge”: A reassuring low-dose gluten challenge in adults on gluten-free diet without proper diagnosis of coeliac disease
Gluten-free diet (GFD) is the one therapy in coeliac disease (CeD). Unfortunately, some patients adopt GFD before the diagnostic work-up. The guidelines suggest a 14-day gluten intake> 3 gr to get CeD diagnosis, although many subjects refuse this approach. Other evidence showed that the intake of 50 mg/day of gluten for 3 months could be useful for CeD diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 23, 2024 Category: Gastroenterology Authors: Antonio Rispo, Alessia Dalila Guarino, Monica Siniscalchi, Nicola Imperatore, Antonella Santonicola, Simona Ricciolino, Roberto de Sire, Benedetta Toro, Nicola Mattia Cantisani, Carolina Ciacci Tags: Alimentary Tract Source Type: research
Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study
ConclusionsThe results of the MR analysis showed that there were causal relationships between type 1 diabetes, rheumatoid arthritis, hypothyroidism, systemic lupus erythematosus, asthma, allergic rhinitis and senile cataract. To clarify the possible role of autoimmune and allergy in the pathophysiology of senile cataract, further studies are needed. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 22, 2024 Category: Allergy & Immunology Source Type: research
CME Exam 1: Accuracy of the No-Biopsy Approach for the Diagnosis of Celiac Disease in Adults: A Systematic Review and Meta-Analysis
(Source: Gastroenterology)
Source: Gastroenterology - March 21, 2024 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research
The Celiac-Disease Superantigen Oligomerizes and Increases Permeability in an Enterocyte Cell Model
Angew Chem Int Ed Engl. 2024 Mar 18:e202317552. doi: 10.1002/anie.202317552. Online ahead of print.ABSTRACTCeliac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting approximately 1% of the global population. The 33-mer deamidated gliadin peptide (DGP) is a metabolically modified wheat-gluten superantigen for CeD. Here, we demonstrate that the 33-mer DGP spontaneously assembles into oligomers with a diameter of approximately 24 nm. The 33-mer DGP oligomers present two main secondary structural motifs-a major polyproline II helix and a minor β-sheet structure. Importantly, in the presence of 33-...
Source: Angewandte Chemie - March 18, 2024 Category: Chemistry Authors: Maria Georgina Herrera Maria Julia Amundarain Philipp W D örfler Veronica I Dodero Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
The Celiac-Disease Superantigen Oligomerizes and Increases Permeability in an Enterocyte Cell Model
Angew Chem Int Ed Engl. 2024 Mar 18:e202317552. doi: 10.1002/anie.202317552. Online ahead of print.ABSTRACTCeliac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting approximately 1% of the global population. The 33-mer deamidated gliadin peptide (DGP) is a metabolically modified wheat-gluten superantigen for CeD. Here, we demonstrate that the 33-mer DGP spontaneously assembles into oligomers with a diameter of approximately 24 nm. The 33-mer DGP oligomers present two main secondary structural motifs-a major polyproline II helix and a minor β-sheet structure. Importantly, in the presence of 33-...
Source: Angewandte Chemie - March 18, 2024 Category: Chemistry Authors: Maria Georgina Herrera Maria Julia Amundarain Philipp W D örfler Veronica I Dodero Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
