Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study
Conclusion: NCGS duodenal mucosa exhibits distinctive changes consistent with an intestinal response to luminal antigens, even at the Marsh 0 stage of villus architecture.PMID:35745217 | DOI:10.3390/nu14122487 (Source: Cancer Control)
Source: Cancer Control - June 24, 2022 Category: Cancer & Oncology Authors: Kamran Rostami Arzu Ensari Michael N Marsh Amitabh Srivastava Vincenzo Villanacci Antonio Carroccio Hamid Asadzadeh Aghdaei Julio C Bai Gabrio Bassotti Gabriel Becheanu Phoenix Bell Camillo Di Bella Anna Maria Bozzola Moris Cadei Giovanni Casella Carlo Ca Source Type: research

Coeliac incorporation strategy impacts visceral branch vessel stability in fenestrated endovascular aneurysm repair
During fenestrated endovascular repair (FEVAR), mesenteric vessels may be incorporated with a scallop or fenestration. The benefits/harms of techniques to incorporate the coeliac axis (CA) have not been assessed for their impact on procedural complexity versus perioperative and longer-term outcomes; this assessment may instruct a balanced operative strategy for the CA and complex FEVAR, minimizing adverse intra/perioperative events, and maximizing durability. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - June 24, 2022 Category: Surgery Authors: Miranda Witheford, Darica Au, Tara M. Mastracci Source Type: research

The Association of Inflammatory Gut Diseases with Neuroinflammatory and Auditory Disorders
Front Biosci (Elite Ed). 2022 Mar 22;14(2):8. doi: 10.31083/j.fbe1402008.ABSTRACTDisorders such as inflammatory bowel disease (IBD) and celiac disease (CeD) result in intestinal hyperpermeability or 'leaky' gut. The increased permeability of the intestinal barrier allows microbial metabolites, toxins, and pathogens to infiltrate the bloodstream and extraintestinal tissues, causing systemic inflammation. Despite differences in aetiology and pathophysiology, IBD and CeD share several extraintestinal manifestations such as neuroinflammation, neurological and psychiatric manifestations, and sensorineural hearing loss (SNHL). T...
Source: Frontiers in Bioscience - Elite - June 22, 2022 Category: Biomedical Science Authors: Dagmara Kociszewska Srdjan M Vlajkovic Source Type: research

Reduced frequency of circulating regulatory T cells and their related immunosuppressive mediators in treated celiac patients
CONCLUSIONS: Despite following the gluten free diet, there may still be residual inflammation in the intestine of CD patients. Accordingly, finding a therapeutic approach based on strengthening the function of Treg cells in CD might be helpful.PMID:35723802 | DOI:10.1007/s11033-022-07674-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - June 20, 2022 Category: Molecular Biology Authors: Nastaran Asri Mohammad Rostami-Nejad Abdolrahim Nikzamir Elham Aghamohamadi Hamid Asadzadeh-Aghdaei Mohammad Reza Zali Source Type: research

Reduced frequency of circulating regulatory T cells and their related immunosuppressive mediators in treated celiac patients
CONCLUSIONS: Despite following the gluten free diet, there may still be residual inflammation in the intestine of CD patients. Accordingly, finding a therapeutic approach based on strengthening the function of Treg cells in CD might be helpful.PMID:35723802 | DOI:10.1007/s11033-022-07674-w (Source: Mol Biol Cell)
Source: Mol Biol Cell - June 20, 2022 Category: Molecular Biology Authors: Nastaran Asri Mohammad Rostami-Nejad Abdolrahim Nikzamir Elham Aghamohamadi Hamid Asadzadeh-Aghdaei Mohammad Reza Zali Source Type: research

Tolerogenic Immune-Modifying Nanoparticles Encapsulating Multiple Recombinant Pancreatic β Cell Proteins Prevent Onset and Progression of Type 1 Diabetes in Nonobese Diabetic Mice
J Immunol. 2022 Jun 20:ji2200208. doi: 10.4049/jimmunol.2200208. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune disease characterized by T and B cell responses to proteins expressed by insulin-producing pancreatic β cells, inflammatory lesions within islets (insulitis), and β cell loss. We previously showed that Ag-specific tolerance targeting single β cell protein epitopes is effective in preventing T1D induced by transfer of monospecific diabetogenic CD4 and CD8 transgenic T cells to NOD.scid mice. However, tolerance induction to individual diabetogenic proteins, for example, GAD65 (glutamic acid...
Source: Journal of Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Joseph R Podojil Samantha Genardi Ming-Yi Chiang Sandeep Kakade Tobias Neef Tushar Murthy Michael T Boyne Adam Elhofy Stephen D Miller Source Type: research

Reduced frequency of circulating regulatory T cells and their related immunosuppressive mediators in treated celiac patients
CONCLUSIONS: Despite following the gluten free diet, there may still be residual inflammation in the intestine of CD patients. Accordingly, finding a therapeutic approach based on strengthening the function of Treg cells in CD might be helpful.PMID:35723802 | DOI:10.1007/s11033-022-07674-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - June 20, 2022 Category: Molecular Biology Authors: Nastaran Asri Mohammad Rostami-Nejad Abdolrahim Nikzamir Elham Aghamohamadi Hamid Asadzadeh-Aghdaei Mohammad Reza Zali Source Type: research

Reduced frequency of circulating regulatory T cells and their related immunosuppressive mediators in treated celiac patients
CONCLUSIONS: Despite following the gluten free diet, there may still be residual inflammation in the intestine of CD patients. Accordingly, finding a therapeutic approach based on strengthening the function of Treg cells in CD might be helpful.PMID:35723802 | DOI:10.1007/s11033-022-07674-w (Source: Mol Biol Cell)
Source: Mol Biol Cell - June 20, 2022 Category: Molecular Biology Authors: Nastaran Asri Mohammad Rostami-Nejad Abdolrahim Nikzamir Elham Aghamohamadi Hamid Asadzadeh-Aghdaei Mohammad Reza Zali Source Type: research

Tolerogenic Immune-Modifying Nanoparticles Encapsulating Multiple Recombinant Pancreatic β Cell Proteins Prevent Onset and Progression of Type 1 Diabetes in Nonobese Diabetic Mice
J Immunol. 2022 Jun 20:ji2200208. doi: 10.4049/jimmunol.2200208. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune disease characterized by T and B cell responses to proteins expressed by insulin-producing pancreatic β cells, inflammatory lesions within islets (insulitis), and β cell loss. We previously showed that Ag-specific tolerance targeting single β cell protein epitopes is effective in preventing T1D induced by transfer of monospecific diabetogenic CD4 and CD8 transgenic T cells to NOD.scid mice. However, tolerance induction to individual diabetogenic proteins, for example, GAD65 (glutamic acid...
Source: Journal of Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Joseph R Podojil Samantha Genardi Ming-Yi Chiang Sandeep Kakade Tobias Neef Tushar Murthy Michael T Boyne Adam Elhofy Stephen D Miller Source Type: research

Transglutaminase 2 affinity and enzyme-substrate intermediate stability as determining factors for T-cell responses to gluten peptides in celiac disease
This article is protected by copyright. All rights reserved.PMID:35715890 | DOI:10.1002/eji.202249862 (Source: European Journal of Immunology)
Source: European Journal of Immunology - June 18, 2022 Category: Allergy & Immunology Authors: Sunniva F Amundsen Jorunn Stamnaes Marie Fleur du Pr é Ludvig M Sollid Source Type: research

Transglutaminase 2 affinity and enzyme-substrate intermediate stability as determining factors for T-cell responses to gluten peptides in celiac disease
This article is protected by copyright. All rights reserved.PMID:35715890 | DOI:10.1002/eji.202249862 (Source: European Journal of Immunology)
Source: European Journal of Immunology - June 18, 2022 Category: Allergy & Immunology Authors: Sunniva F Amundsen Jorunn Stamnaes Marie Fleur du Pr é Ludvig M Sollid Source Type: research

Transglutaminase 2 affinity and enzyme-substrate intermediate stability as determining factors for T-cell responses to gluten peptides in celiac disease
This article is protected by copyright. All rights reserved.PMID:35715890 | DOI:10.1002/eji.202249862 (Source: European Journal of Immunology)
Source: European Journal of Immunology - June 18, 2022 Category: Allergy & Immunology Authors: Sunniva F Amundsen Jorunn Stamnaes Marie Fleur du Pr é Ludvig M Sollid Source Type: research