The Economic Iceberg of Celiac Disease: More than the Cost of Gluten-Free Food
Celiac disease (CeD) is a chronic autoimmune disorder of global relevance, with the potential for acute and long-term complications. However, the economic burden of CeD is rarely considered and largely thought of as limited to the cost of gluten-free food. Fortunately, recent research has shed light on the various societal costs of CeD across the healthcare continuum.In this article, we summarize the current evidence on the economic impacts of CeD which suggest that the societal economic burden of CeD stretches beyond the cost of gluten-free food. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Soran R. Bozorg, Anne Lee, Karl M årild, Joseph Murray Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Past, present and future of non-invasive tests to assess gluten exposure, celiac disease activity, and end-organ damage
Although many biomarkers have been proposed and several are in widespread clinical use, there is no single readout or combination of readouts that correlates tightly with gluten exposure, disease activity or end-organ damage in treated celiac disease patients. Challenges to developing and evaluating better biomarkers include significant interindividual variability related to immune amplification of gluten exposure and how effects of immune activation are manifest. Furthermore, the current “gold standard” for assessment of end-organ damage, small intestinal biopsy, is itself highly imperfect, such that a marker that is ...
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Jocelyn A. Silvester, Luca Elli, Chaitan Khosla, Jason Tye-Din Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
New insights on genes, gluten and immunopathogenesis of celiac disease
Celiac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals on consumption of cereal gluten proteins. It is a unique complex immune disorder to study as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical and immunological studies, which together have revealed mechanisms of gluten peptide modification and HLA binding thereby enabling a maladapted anti-gluten immune response. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Val érie Abadie, Arnold Han, Bana Jabri, Ludvig M. Sollid Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
High Fat Diet –Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies
Wheat gluten may play a role for development of life-style related diseases in populations on a high fat diet. Mice feed high fat diet show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota and the immune cell profile in liver. AbstractThe intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In ce...
Source: Molecular Nutrition and Food Research - April 18, 2024 Category: Food Science Authors: Yuri Haneishi,
Lucia Treppiccione,
Francesco Maurano,
Diomira Luongo,
Junki Miyamoto,
Mauro Rossi Tags: Review Source Type: research
Hyperpigmentation at diabetes technology sites may be indicative of evolving Addisons disease
A 12-year-old boy with type 1 diabetes mellitus and coeliac disease reported 2–3 months of skin darkening at his insulin pump cannula and continuous glucose monitor sites (figure 1). For the preceding 9 months, he had localised itching and redness, which had been managed as allergic contact dermatitis by a dermatologist. He continued to use the dressings and these symptoms had improved. Hyperpigmentation was noted over his knuckles and periorally. He had no symptoms of adrenal insufficiency and was gaining weight (98th centile) and height (50th centile). A synacthen test had a suboptimal peak cortisol (370 nmol/L (&g...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Moon, R. J., Rowland, A. C., Davies, J. H. Tags: Miscellanea Source Type: research
Clinical presentation and spectrum of gluten symptomatology in celiac disease
Views on the clinical presentation and symptomatology of celiac disease have evolved alongside advances in disease detection and understanding of disease pathogenesis. While historically regarded a pediatric illness characterized by malabsorption, it is now better viewed as an immune illness of gluten-specific T cells with systemic manifestations affecting all ages. Its broad presentation, including frequent extraintestinal manifestations and asymptomatic disease, contributes to suboptimal disease detection. (Source: Gastroenterology)
Source: Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Dawn W. Adams, Stephanie Moleski, Jacqueline Jossen, Jason A. Tye-Din Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
