Two randomised crossover multicentre studies investigating gastrointestinal symptoms after bread consumption in individuals with non-coeliac wheat sensitivity: do wheat species and fermentation type matter?
CONCLUSIONS: The majority of NCWS individuals experienced some GI symptoms for at least one of the breads, but on a group level, no differences were found between different grains for either YF or SF breads.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04084470(https://classic.CLINICALTRIALS: gov/ct2/show/NCT04084470).PMID:38373694 | DOI:10.1016/j.ajcnut.2024.02.008 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - February 19, 2024 Category: Nutrition Authors: Marlijne C G de Graaf Emma Timmers Bo Bonekamp Gonny van Rooy Ben J M Witteman Peter R Shewry Alison Lovegrove Antoine H P America Luud J W J Gilissen Daniel Keszthelyi Fred J P H Brouns Daisy M A E Jonkers Source Type: research

Two randomised crossover multicentre studies investigating gastrointestinal symptoms after bread consumption in individuals with non-coeliac wheat sensitivity: do wheat species and fermentation type matter?
CONCLUSIONS: The majority of NCWS individuals experienced some GI symptoms for at least one of the breads, but on a group level, no differences were found between different grains for either YF or SF breads.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04084470(https://classic.CLINICALTRIALS: gov/ct2/show/NCT04084470).PMID:38373694 | DOI:10.1016/j.ajcnut.2024.02.008 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - February 19, 2024 Category: Nutrition Authors: Marlijne C G de Graaf Emma Timmers Bo Bonekamp Gonny van Rooy Ben J M Witteman Peter R Shewry Alison Lovegrove Antoine H P America Luud J W J Gilissen Daniel Keszthelyi Fred J P H Brouns Daisy M A E Jonkers Source Type: research

Two randomised crossover multicentre studies investigating gastrointestinal symptoms after bread consumption in individuals with non-coeliac wheat sensitivity: do wheat species and fermentation type matter?
CONCLUSIONS: The majority of NCWS individuals experienced some GI symptoms for at least one of the breads, but on a group level, no differences were found between different grains for either YF or SF breads.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04084470(https://classic.CLINICALTRIALS: gov/ct2/show/NCT04084470).PMID:38373694 | DOI:10.1016/j.ajcnut.2024.02.008 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - February 19, 2024 Category: Nutrition Authors: Marlijne C G de Graaf Emma Timmers Bo Bonekamp Gonny van Rooy Ben J M Witteman Peter R Shewry Alison Lovegrove Antoine H P America Luud J W J Gilissen Daniel Keszthelyi Fred J P H Brouns Daisy M A E Jonkers Source Type: research

Two randomised crossover multicentre studies investigating gastrointestinal symptoms after bread consumption in individuals with non-coeliac wheat sensitivity: do wheat species and fermentation type matter?
CONCLUSIONS: The majority of NCWS individuals experienced some GI symptoms for at least one of the breads, but on a group level, no differences were found between different grains for either YF or SF breads.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04084470(https://classic.CLINICALTRIALS: gov/ct2/show/NCT04084470).PMID:38373694 | DOI:10.1016/j.ajcnut.2024.02.008 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - February 19, 2024 Category: Nutrition Authors: Marlijne C G de Graaf Emma Timmers Bo Bonekamp Gonny van Rooy Ben J M Witteman Peter R Shewry Alison Lovegrove Antoine H P America Luud J W J Gilissen Daniel Keszthelyi Fred J P H Brouns Daisy M A E Jonkers Source Type: research

Two randomised crossover multicentre studies investigating gastrointestinal symptoms after bread consumption in individuals with non-coeliac wheat sensitivity: do wheat species and fermentation type matter?
CONCLUSIONS: The majority of NCWS individuals experienced some GI symptoms for at least one of the breads, but on a group level, no differences were found between different grains for either YF or SF breads.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04084470(https://classic.CLINICALTRIALS: gov/ct2/show/NCT04084470).PMID:38373694 | DOI:10.1016/j.ajcnut.2024.02.008 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - February 19, 2024 Category: Nutrition Authors: Marlijne C G de Graaf Emma Timmers Bo Bonekamp Gonny van Rooy Ben J M Witteman Peter R Shewry Alison Lovegrove Antoine H P America Luud J W J Gilissen Daniel Keszthelyi Fred J P H Brouns Daisy M A E Jonkers Source Type: research

Two randomised crossover multicentre studies investigating gastrointestinal symptoms after bread consumption in individuals with non-coeliac wheat sensitivity: do wheat species and fermentation type matter?
CONCLUSIONS: The majority of NCWS individuals experienced some GI symptoms for at least one of the breads, but on a group level, no differences were found between different grains for either YF or SF breads.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04084470(https://classic.CLINICALTRIALS: gov/ct2/show/NCT04084470).PMID:38373694 | DOI:10.1016/j.ajcnut.2024.02.008 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - February 19, 2024 Category: Nutrition Authors: Marlijne C G de Graaf Emma Timmers Bo Bonekamp Gonny van Rooy Ben J M Witteman Peter R Shewry Alison Lovegrove Antoine H P America Luud J W J Gilissen Daniel Keszthelyi Fred J P H Brouns Daisy M A E Jonkers Source Type: research

Associations of Eosinophilic Gastrointestinal Disorders with Other Gastrointestinal and Allergic Diseases
Eosinophilic gastrointestinal disorders (EGIDs) are becoming more common causing significant suffering and reduced quality of life. These conditions can affect different parts of the digestive system, either individually or in combination. Recognition of their link to allergic disorders or other gastrointestinal (GI) diseases has raised questions about their shared underlying mechanisms, which has had implications for diagnosis and management. The authors critically examine the current understanding of the connection between EGIDs and allergic conditions (ie, atopic dermatitis, allergic rhinitis, asthma, and food allergy) ...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Salvatore Oliva, Emily Clarke McGowan Source Type: research

Rare diagnosis of an Epstein-Barr virus-positive extracavitary/solid variant of primary effusion lymphoma by duodenal endoscopic biopsy in a human immunodeficiency virus-seronegative and immunocompetent patient: A case report
We report the case of a 50-year-old HIV-seronegative male patient who presented with icterus and cholestasis. Computed tomography revealed a 80 × 56 mm abdominal mass. Fine-needle aspiration biopsy was performed from the celiac lymph nodes and pancreatic head, under endoscopic ultrasonography guidance. A duodenal endoscopic biopsy was taken from the infiltration area, and a core biopsy was performed for the portal hilar mass. All biopsies showed similar cytohistopathological features. LCA-positive lymphoid neoplasia had a plasmacytoid/anaplastic morphology and null cell phenotype. HHV-8 and Epstein-Barr virus-encoded smal...
Source: Indian Journal of Pathology and Microbiology - February 15, 2024 Category: Pathology Authors: Beril Guler Guven Cetin Source Type: research

Rare diagnosis of an Epstein-Barr virus-positive extracavitary/solid variant of primary effusion lymphoma by duodenal endoscopic biopsy in a human immunodeficiency virus-seronegative and immunocompetent patient: A case report
We report the case of a 50-year-old HIV-seronegative male patient who presented with icterus and cholestasis. Computed tomography revealed a 80 × 56 mm abdominal mass. Fine-needle aspiration biopsy was performed from the celiac lymph nodes and pancreatic head, under endoscopic ultrasonography guidance. A duodenal endoscopic biopsy was taken from the infiltration area, and a core biopsy was performed for the portal hilar mass. All biopsies showed similar cytohistopathological features. LCA-positive lymphoid neoplasia had a plasmacytoid/anaplastic morphology and null cell phenotype. HHV-8 and Epstein-Barr virus-encoded smal...
Source: Indian Journal of Pathology and Microbiology - February 15, 2024 Category: Pathology Authors: Beril Guler Guven Cetin Source Type: research

Cardiomyopathy, carnitine deficiency, and celiac disease
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - February 15, 2024 Category: Pediatrics Source Type: research

Association between celiac disease and irritable bowel syndrome: a nationwide cohort study
To determine the risk of irritable bowel syndrome (IBS) diagnosis in patients with celiac disease (CD) compared to general population comparators. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 15, 2024 Category: Gastroenterology Authors: Karl M årild, Jonas Söderling, Benjamin Lebwohl, Peter HR. Green, Hans Törnblom, Magnus Simrén, Kyle Staller, Ola Olén, Jonas F. Ludvigsson Source Type: research

Intestinal mRNA expression analysis of polarity ‐related genes identified the discriminatory ability of CRB3 as a diagnostic marker for celiac disease
ConclusionThe aim of the current study was to evaluate the changes in the mRNA expression levels ofSCRIB,PRKCZ,LKB1, andCRB3 genes in the small intestinal biopsy samples of CD patients in comparison to the healthy control subjects. Our data uncover the importance of polarity-related genes (especiallyCRB3) in CD pahtomechanism, that may facilitate the planning of the future studies looking for finding innovative diagnostic and therapeutic strategies for CD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Tannaz Taraz, Nastaran Asri, Ehsan Nazemalhosseini ‐Mojarad, Flora Forouzesh, Mostafa Rezaei‐Tavirani, Mohammad Rostami‐Nejad Tags: ORIGINAL ARTICLE Source Type: research

Reply
We thank Dr Silberg and colleagues1 for their constructive critique of our multidisciplinary appropriateness study2 that aimed to develop appropriate designs and configurations of randomized trials in celiac disease. We agree that the patient voice is essential in multiple aspects of drug development, including identification of unmet needs, development of patient-reported outcomes, foreseeing feasibility of study protocols, and implementation and dissemination of results. (Source: Gastroenterology)
Source: Gastroenterology - February 13, 2024 Category: Gastroenterology Authors: Benjamin Lebwohl, Christopher Ma, Joseph A. Murray Tags: Correspondence Source Type: research

A look into the future: Are we ready for an approved therapy in celiac disease?
As it appears that we are currently at the cusp of an era in which drugs that are new, re-purposed or as “supplements”, will be introduced to the management of celiac disease, we need to reflect if the framework is set for celiac disease to be increasingly treated by pharmaceuticals as well as diet. This refers to reflecting on the rigor of current diagnostic practices, the limitations of the curre nt standard of care that is gluten-free diet, and that we lack objective markers of disease severity. (Source: Gastroenterology)
Source: Gastroenterology - February 12, 2024 Category: Gastroenterology Authors: Robert P. Anderson, Ritu Verma, Michael Schumann Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research

Microscopic colitis found together with celiac disease in a female population is associated with one episode of lymphocytic colitis
Microscopic colitis (MC) is considered a chronic disease associated with autoimmune disease, smoking, and drugs. The aim was to examine the association between MC and celiac disease, adjusted for smoking, cons... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - February 12, 2024 Category: Gastroenterology Authors: Bodil Roth and Bodil Ohlsson Tags: Research Source Type: research