Predominantly Antibody Deficiency and the Association with Celiac Disease in Sweden: A Nationwide Case-Control Study
Predominantly antibody deficiency (PAD) is associated with non-infectious inflammatory gastrointestinal (GI) disease. Population estimates of celiac disease (CeD) risk in those with PAD are limited. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 5, 2024 Category: Allergy & Immunology Authors: Daniel V. DiGiacomo, Bjorn Roelstraete, Benjamin Lebwohl, Peter H.R. Green, Lennart Hammarstr öm, Jocelyn R. Farmer, Hamed Khalili, Jonas F. Ludvigsson Tags: Original Article Source Type: research
Prevalence of celiac-related antibodies and its impact on metabolic control in Egyptian children with type 1 diabetes mellitus
The simultaneous presence of celiac disease and type 1 diabetes (T1DM) is coupled with more hazards of comorbidities and complications. This current study aimed to screen for celiac disease in Egyptian childre... (Source: BMC Pediatrics)
Source: BMC Pediatrics - February 5, 2024 Category: Pediatrics Authors: Khaled A. Abdel Baseer, Abdallah E. Mohammed, Aya Mohamed Abo Elwafa and Hala M. Sakhr Tags: Research Source Type: research
Predominantly antibody deficiency and the association with celiac disease in Sweden
Predominantly antibody deficiency (PAD) is associated with noninfectious inflammatory gastrointestinal disease. Population estimates of celiac disease (CeD) risk in those with PAD are limited. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 5, 2024 Category: Allergy & Immunology Authors: Daniel V. DiGiacomo, Bjorn Roelstraete, Benjamin Lebwohl, Peter H.R. Green, Lennart Hammarstr öm, Jocelyn R. Farmer, Hamed Khalili, Jonas F. Ludvigsson Source Type: research
Celiac Disease and Depressive Disorders as nutritional implications related to common factors - a comprehensive review
Behav Brain Res. 2024 Feb 1:114886. doi: 10.1016/j.bbr.2024.114886. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease affecting the small intestine. The only treatment strategy for CD is the gluten-free diet (GFD). One of the more common mental disorders in CD patients is major depressive disorder (MDD). The influence of GFD on the occurrence of MDD symptoms in patients with CD will be evaluated. This diet often reduces nutritional deficiencies in these patients and also helps to reduce depressive symptoms. Both disease entities are often dominated by the same deficiencies of nutrients such as...
Source: Behavioural Brain Research - February 3, 2024 Category: Neurology Authors: Joanna Mikulska Diana Pietrzak Pawe ł Rękawek Krystian Siudaj Łucja Justyna Walczak-Nowicka Mariola Herbet Source Type: research
Celiac Disease and Depressive Disorders as nutritional implications related to common factors - a comprehensive review
Behav Brain Res. 2024 Feb 1:114886. doi: 10.1016/j.bbr.2024.114886. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease affecting the small intestine. The only treatment strategy for CD is the gluten-free diet (GFD). One of the more common mental disorders in CD patients is major depressive disorder (MDD). The influence of GFD on the occurrence of MDD symptoms in patients with CD will be evaluated. This diet often reduces nutritional deficiencies in these patients and also helps to reduce depressive symptoms. Both disease entities are often dominated by the same deficiencies of nutrients such as...
Source: Brain Research - February 3, 2024 Category: Neurology Authors: Joanna Mikulska Diana Pietrzak Pawe ł Rękawek Krystian Siudaj Łucja Justyna Walczak-Nowicka Mariola Herbet Source Type: research
Celiac disease diagnosis from endoscopic images based on multi-scale adaptive hybrid architecture model
Conclusion:
This study introduces a deep learning network equipped with both global feature response and local feature extraction capabilities. This innovative architecture holds significant promise for the accurate diagnosis of celiac disease by leveraging endoscopic images captured from diverse anatomical sites.
.PMID:38306971 | DOI:10.1088/1361-6560/ad25c1 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - February 2, 2024 Category: Physics Authors: Yilei Wang Tian Shi Feng Gao 伟 生 田 Long Yu Source Type: research
Moving Away from Biopsy Confirmation of Celiac Disease
(Source: Gastroenterology)
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Benjamin Lebwohl Tags: Editorials Source Type: research
Patient and Community Health Global Burden in a World with more Celiac Disease
Celiac disease is one of the commonest life-long disorders worldwide, with a prevalence mostly ranging between 0.7 and 2.9 % in the general population and a higher frequency in females and in well-defined at-risk groups, such as relatives of affected individuals and patients with autoimmune co-morbidities. Increasing clinical detection is facilitated by improving awareness, implementation of a case-finding approach, and serology availability for screening at risk patients, among other factors. Nevertheless, due to huge clinical variability many CeD cases still escape diagnosis in most countries, unless actively searched by...
Source: Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Simona Gatti, Alberto Rubio-Tapia, Govind Makharia, Carlo Catassi Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Alpha/Gamma-Gliadins are the Superior Target Antigens for Detection of Gluten in Foods by Immunoassay
Gliadins, components of wheat gluten, can elicit severe allergic reactions in sensitive individuals and cause severe illness in celiac disease patients. Thus, reliable detection of wheat in food products is critical. The aim was to develop a sensitive immunoassay for the quantitative measurement of wheat in food products. Here, we have compared the performance of antibodies raised against two candidate immunogens: natural Alpha/gamma-gliadins (Tri a 20-21) and recombinant Omega5-gliadin (Tri a 19) for detection of wheat in food matrices. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Sayeh Agah, Kristina Reid Black, Martin Chapman, Sabina Wuenschmann Source Type: research
Predominant Antibody Deficiency and the Association with Celiac Disease in Sweden: A Nationwide Case-Control Study
Predominant antibody deficiency (PAD) is associated with non-infectious inflammatory gastrointestinal (GI) disease. Population estimates of celiac disease (CeD) risk in those with PAD are limited. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Daniel Digiacomo, Bjorn Roelstraete, Benjamin Lebwohl, Peter Green, Lennart Hammarstr öm, Jocelyn Farmer, Hamed Khalili, Jonas Ludvigsson Source Type: research
Using a fluorescent enzyme-linked immunoassay as the first-line screening test for celiac disease obviates testing serum IgA levels and provides cost savings
Selective IgA deficiency (sIgAD - serum IgA 4years old), the most common inborn error of immunity (IEI), is 10-15 times more common in celiac disease (CD). Qatar has high prevalence of IEI and type 1 diabetes, the latter associated with CD. Our pre-existing CD protocol included serum IgA, tissue transglutaminase (tTG - IgA, IgG isotypes), endomysial antibodies (EMA) on all patients. It is reported that the IgA-tTG-IgA Celikey enzyme-linked immunoassay (ELiA) can detect IgA deficiency. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Mohammed Karim, Isabella Ledoux, Ferdousey Aziz Source Type: research
Obsessive –Compulsive Symptomatology and Disgust Propensity in Disordered Eating Behaviors of Adolescents with Celiac Disease
ConclusionHigher obsessionality, accompanied by disgust-related evaluative conditioning processes, may contribute to constructing a cognitive network consisting of hypervigilance and catastrophic interpretations towards benign somatic stimulations, food-related preoccupations, and avoidant behaviors in the disordered eating of adolescents with CD. The reciprocal relationship between lifelong GFD and DEA, mediated by obsessionality and disgust propensity, was supported by current findings that could guide clinicians in the management of maladaptive eating behaviors in adolescents with CD. (Source: International Journal of Behavioral Medicine)
Source: International Journal of Behavioral Medicine - February 1, 2024 Category: Psychiatry Source Type: research
The financial impact on people with coeliac disease of withdrawing gluten-free food from prescriptions in England: findings from a cross-sectional survey
A lifelong gluten-free diet is the only treatment for coeliac disease. The cost and availability of gluten-free substitute food (GFSF) remain challenging. Some local areas in England have stopped gluten-free p... (Source: BMC Health Services Research)
Source: BMC Health Services Research - January 30, 2024 Category: General Medicine Authors: Thavapriya Sugavanam, Helen Crocker, Mara Violato and Michele Peters Tags: Research Source Type: research
Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study
CONCLUSIONS: This study revealed an increased risk of autoimmune disease among CeD patients compared with controls. However, older age at CeD diagnosis did not seem to escalate the risk of autoimmune diseases.PMID:38286066 | DOI:10.1016/j.jaut.2024.103170 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - January 29, 2024 Category: Allergy & Immunology Authors: Shuai Yuan Daniel Leffler Benjamin Lebwohl Peter H R Green Susanna C Larsson Jonas S öderling Jiangwei Sun Jonas F Ludvigsson Source Type: research
Opportunities for Improving Biopsy and Non-Biopsy-Based Diagnosis of Celiac Disease
The accumulating data regarding a non-biopsy diagnosis of celiac disease has led to its adoption in certain scenarios, though debate on whether and when to use non-biopsy criteria in clinical practice remains ongoing. Despite the growing popularity and evidence basis for a biopsy-free approach to diagnosis in the context of highly elevated serologies, there will nevertheless continue to be a role for a biopsy in some groups. The present review summarizes the current evidence supporting a non-biopsy approach, arguments supporting continued reliance on biopsy, and focuses on opportunities to improve both approaches. (Source: Gastroenterology)
Source: Gastroenterology - January 29, 2024 Category: Gastroenterology Authors: Marie E. Robert, Carolina Ciacci, Benjamin Lebwohl Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
