More on CCL17 as a Target to Reduce Inflammation in Cardiovascular Disease
Atherosclerosis is the buildup of fatty plaques in the walls of blood vessels, impeding blood flow and eventually rupturing to produce a heart attack or stroke. It is the single largest cause of human mortality. Atherosclerosis is in part an inflammatory condition, accelerated by the state of chronic inflammation that arises in later life. In this context, levels of CCL17 have been shown to rise with age, while inhibition of CCL17 has been shown to reduce chronic inflammation and slow the progression of atherosclerosis. This outcome is achieved via effects on T cell behavior; CCL17 is expressed on the surface of dendritic ...
Source: Fight Aging! - January 31, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Science of Happiness: Proven Habits for a Fulfilling Life
The majority of Americans are not experiencing much happiness these days. According to a poll, only 19% of the surveyed individuals described themselves as "very happy." Other comparable studies also demonstrated low happiness ratings. While not entirely surprising given the turbulent economy and other concerns, these insights reveal that many people are not reaping the benefits of daily fulfillment.
Happiness has long been associated with numerous personal and familial benefits. When we are happy, we are less likely to be burdened by the devastating effects of stress, such as an increased risk of developing cardiovascu...
Source: PickTheBrain | Motivation and Self Improvement - January 31, 2024 Category: Consumer Health News Authors: Mike Szczesny Tags: depression featured happiness philosophy self improvement Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Quantifying the Effects of Time Spent Sitting on Mortality
The study noted here provides an interesting addition to the debate over whether time spent sitting is harmful to health independently of its contribution to time spent being sedentary. Time spent sitting increases mortality, while time spent active or undertaking exercise decreases mortality. The results of this large epidemiological study quantify how much additional exercise is required to mitigate the mortality increase resulting from time spent sitting. The results also have the look of common sense at the end of the day; the intuition that one should compensate for a desk job with additional exercise outside work tur...
Source: Fight Aging! - January 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Icariin Extends Life in Nematode Worms
Icariin supplementation has been shown to improve health and the state of the gut microbiome in mice, and appears to be neuroprotective in other studies. Here researchers show that icariin extends life in nematode worms by affecting the well-studied DAF-2 gene, and to a similar degree to DAF-2 mutation. Whether all of this will translate to an interesting effect size in humans remains to be seen; other interventions that alter metabolism, particularly this area of metabolic regulation, have produced diminishing returns in longer-lived species, where there is data to directly compare.
Aging presents an increasingly...
Source: Fight Aging! - January 24, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
HDL dysfunction & It ’ s clinical Implication
High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked)
We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are ...
Source: Dr.S.Venkatesan MD - January 21, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Special circumstances where warfarin is favored over DOACs
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - January 21, 2024 Category: Internal Medicine Tags: cardiovascular hematology hospital medicine pharmacology Source Type: blogs
ACC atrial fibrillation guidelines 2023
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - January 20, 2024 Category: Internal Medicine Tags: cardiovascular guidelines Source Type: blogs
How Your Eating Routine Could Reduce Heart Attack Risk By One-Third
Diet is not the only thing that can improve cardiovascular health, adopting this meal timing is also important. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 20, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Heart Disease Source Type: blogs
The Inflammasome as a Target for the Next Generation of Anti-Inflammatory Therapies
With advancing age, a wide range of mechanisms act to provoke the immune system into a state of constant inflammatory signaling and activation. Age-related mitochondrial dysfunction leads to mislocalized mitochondrial DNA fragments that trigger the cGAS-STING pathway to provoke inflammation. Senescent cells produce pro-inflammatory signaling, and their numbers increase with age. Visceral fat tissue produces signaling similar that resulting from infected cells. The increased presence of protein aggregates aggravates immune cells inside and outside of the brain. And so forth. Given all of this, actually fixing the issue of a...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
knownwell Raises $20M Series A From A16Z to Scale the First Patient-Centered Healthcare Home For Those With Overweight and Obesity
Building on This Mission, the Company is Launching an Adolescent Metabolic Health Program to Combat Rising Child Obesity Rates
knownwell, an in-person and virtual, weight-inclusive primary care and metabolic health company, today announced that it has raised a $20 million Series A funding round led by a16z with participation from existing investors including Flare Capital Partners. This brings knownwell’s total funding to $24.5 million and highlights a growing demand for weight-inclusive care companies focusing on whole-person treatment approaches to obesity beyond just short-term approaches like GLP-1 utilization organi...
Source: EMR and HIPAA - January 15, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT a16z Brooke Boyarsky Pratt Dr. Angela Fitch Flare Capital Partners Health IT Funding Health IT Fundings Health IT Investment knownwell Vineeta Agarwala Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Effects of LDLR Variants on Longevity via Lowered Cardiovascular Disease
This study suggests that LDLR is a promising genetic target for human longevity. Lipid-related gene targets, such as PCSK9, CETP, and APOC3, might potentially regulate human lifespan, thus offering promising prospects for developing newer nonstatin therapies.
Link: https://doi.org/10.1186/s12944-023-01983-0 (Source: Fight Aging!)
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chronological Age is Not a Good Component of Patient Risk Assessment
Chronological age is embedded in a great many standardized, widely-used protocols for patient risk assessment. Age-related diseases are, after all, age-related, and this use of chronological age has long seemed a reasonable choice. That said, we are now moving into an era in which novel means of measuring biological age are under development, such as epigenetic clocks.
Biological age is the burden of damage and dysfunction resulting from the causative processes of aging. Obviously, this should better reflect the odds of suffering age-related disease. While biological age correlates with chronological age, there is a...
Source: Fight Aging! - January 9, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
