Rate vs Rhythm Control in Atrial Fibrillation
Rate vs rhythm control as a management strategy in atrial fibrillation has been a long standing topic for debate. Though at one look rhythm control would appear to be the ideal strategy, long term adverse effects of the currently available medications for rhythm control is the often cited down side. AFFIRM [1] and RACE [2] trials were the main reason for the debate as they failed to show any benefit for the rhythm control strategy. AF-CHF trial in those with AF and congestive heart failure also failed to show any advantage for the rhythm control strategy [3]. But there have been important criticisms as well [4]. In AFFIRM...
Source: Cardiophile MD - October 26, 2023 Category: Cardiology Authors: Johnson Francis Tags: ECG / Electrophysiology General Cardiology Source Type: blogs
Regulators Will Likely Continue to Make Development Difficult, Even After Aging is Recognized as a Medical Condition
It is the nature of regulators at the FDA to aim for zero risk at any cost, and this is particularly apparent in the case of preventative therapies intended to be deployed widely in comparatively healthy people. Absent unusual political pressure, any number of ongoing deaths while therapies are assessed is treated as an acceptable cost to avoid even small numbers of deaths that may occur due to use of a new therapy. Thus even after aging is recognized as a medical condition by regulators, it is likely that they will make it too expensive to assess potential therapies. Instead, companies will gain clinical approval for trea...
Source: Fight Aging! - October 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Serum Galectin-3 Correlates with Frailty Risk
In this study, we aimed to address the change of Gal-3 levels in human whole blood with frailty. We performed serum biochemical and peripheral blood mononuclear cells (PBMC) microarray analyses in humans to determine the secretory phenotype characteristics of frailty. Furthermore, we used the frail mouse model to study the significantly altered behavioral phenotype and associated secreted Gal-3 levels in blood samples to reveal the Gal-3-dependent inflammatory dysregulation of frailty. (Source: Fight Aging!)
Source: Fight Aging! - October 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is the normal Pericardial thickness ?
An unusal conversation with a flamboyant student fellow,
May I know , What is the normal Pericardial thickness, ?
Which pericardium you mean sir ? ,Parietal or visceral?
Would like to know both .
It is variable sheet of tissue .You want the thinnest part or thickest part ?
Don’t beat around the bush .Tell some answer.
You want, autopsy thickness, or real life thickness as surgeon sees it ?
I want it in practical Imaging modality
Do you want Echo, CT or MRI thickness ?
I should say , its too much for a first-year fellow in reverse questioning!
Ok relax sir, shall I tell the systolic ...
Source: Dr.S.Venkatesan MD - October 20, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Lateral Flow Test for Gingivitis
Researchers at the University of Cincinnati have developed a lateral flow assay that can detect bacterial toxins from Porphyromonas gingivalis, the causative bacteria for gingivitis. The technology could make it easier and faster to identify early-stage gingivitis, which can lead to periodontitis and eventual tooth loss, as well as contributing to a variety of other diseases such as stroke and heart disease. The lateral flow assay requires a small saliva sample, and can provide results very quickly, but does require the saliva sample to be pre-treated with potato starch to deactivate salivary amylase, an enzyme that can in...
Source: Medgadget - October 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dentistry Diagnostics gingivitis UofCincy Source Type: blogs
Towards Inhibition of α-Synuclein Aggregation
We report that αS1-25 inhibits lipid-induced αS aggregation in a dose-dependent manner. αS1-25 functions by binding to lipids to prevent αS binding, with both αS and peptide requiring lipid for inhibition to occur. These findings present a potential mechanistic route for the treatment or prevention of PD. (Source: Fight Aging!)
Source: Fight Aging! - October 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How is forward cardiac output affected in MR & TR ?
AV valves exist to divert blood to the outflows when ventricles are contracting. If they leak significantly, obviously there are major consequences. What happens to the net cardiac output when these valves leak?
Clincally , we know ,fatigue is sign of reduced forward cardaic out put , that is more common in MR. But, edema , congestion, muscle fatigue is eqaully if not more common with TR. One importnat diference is MR jet is mainly a hemodynamic trouble in pulmonary circuit while TR jet , has one more component hits on liver function making it metabolic consequnce as well.
Can’t escape, tell us your answer for...
Source: Dr.S.Venkatesan MD - October 18, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized atrial functional tr cardiac out put in tr forward cardiac out out meer vs teer mitra clip RESEARCH TOPIC FOR DM CARDIOLOGY tricuspid annulus tricuspid vs mitral regurgitation Source Type: blogs
Aspects of Social Determinants of Health: An Introduction
It’s always been pretty obvious that factors such as wealth, race, education, and the quality of food and water have enormous impacts on health. But only in the past few years have the medical professions tried to quantify and capture these factors. Given that the field is increasingly digitized and data-driven, health IT is responsible for collecting and analyzing social determinants of health (SDoH). Data can both call out SDoH and help to address its effects.
An example of calling out SDoH was cited by Dr. Sherri Onyiego, Medical Director for the Texas Market at Equality Health. They use claims data to track use o...
Source: EMR and HIPAA - October 16, 2023 Category: Information Technology Authors: Andy Oram Tags: Analytics/Big Data C-Suite Leadership Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Regulations Care Management SDOH Social Determinants of Health Source Type: blogs
Current Role of Digoxin in Heart Failure as Per Guidelines and DIGIT-HF trial of Digitoxin
Use of digoxin in heart failure has come down markedly over the past decades due to concerns of toxicity and availability of more effective medications. Concern for toxicity is because of the narrow therapeutic window of digoxin along with interactions with other cardiovascular drugs and in those with renal dysfunction, which can enhance toxicity. Though an initial loading dose was given earlier, it is no longer used. As per the 2021 ESC guidelines, digoxin may be considered in heart failure with reduced ejection fraction, in sinus rhythm for reducing risk of hospitalizations, though there is no mortality benefit. It may ...
Source: Cardiophile MD - October 16, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pigs as a Model to Explore Links Between the Gut Microbiome and Chronic Inflammation in Aging
This study employed a comprehensive metagenomic analysis encompassing saliva and stool samples obtained from 45 pigs representing three distinct age groups, alongside serum metabolomics and lipidomics profiling. Our findings unveiled discernible modifications in the gut and oral microbiomes, serum metabolome, and lipidome at each age stage. Specifically, we identified 87 microbial species in stool samples and 68 in saliva samples that demonstrated significant age-related changes. Notably, 13 species in stool, including Clostridiales bacterium, Lactobacillus johnsonii, and Oscillibacter spp., exhibited age-dependent alterat...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Age-Related DNA Damage and Epigenetic Changes
This review paper covers both genetic and epigenetic changes that occur with age, taking a broad look at everything from telomere length to stochastic mutational damage to alterations in chromatin structure. As for all aspects of aging at the level of cellular biochemistry, it is easier to catalog than it is to determine relationships between these items, or to determine whether one characteristic of aging cellular biochemistry is more or less important than another when it comes to age-related disease and loss of function. Greater funding for the field would allow researchers to take the best of brute force approaches, wh...
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What is the natural history of TCFA “ Thin cap fibro atheroma ” ?
(Why should the number 65 bother us in TCFA-detected by OCT? Does this number really deserve that respect? Trying to find some truths from 8 questions with & without evidence.)
1. Does TCFA really make a plaque vulnerable?
A.Yes
B. No
C. Maybe
Answer: Yes & Maybe. But there seem to be more important factors other than TCFA for a plaque to become vulnerable making TCFA not really a big deal.
2. TCFP is more common in which lesions?
A.Flow limiting lesion
B.Nonflow limiting lesion
C.No relationship between TCFA and flow
Answer: No relation, rather a random relationship.
3. What...
Source: Dr.S.Venkatesan MD - October 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Image quiz : What is the Investigation & What is the diagnosis ?
Image courtesey : Sekhar, S. et al Canadian Journal of Cardiology, 2015 (Ref 2)
Coronary stent infection (CSI) is no longer a rare and fancy diagnosis. It is increasingly recognized and is equivalent to infective endocarditis. Though CSI appear simple & practical terminology, Infective endo-coronary arteritis may be the ideal term for this device-related infection.
Any prolonged fever following PCI must be investigated with this condition in mind. Unlike other forms of infective endocarditis, vegetations are rare, or do not occur . Instead, the infection erodes endothelium, often leading to the development o...
Source: Dr.S.Venkatesan MD - October 6, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
