AI ’ s Unforeseen Medical Discoveries: The Curious Case Of Unusual Associations
Artificial intelligence can do a plethora of astonishing things, which has been discussed thoroughly in the past year. We train models to assist medical work, from administration to image analysis, from triage to mental health support. And every now and then AI has curious medical discoveries, detecting things that – to the best of our human knowledge – should not be detectable from the input data. Like knowing the race of the patient from chest X-rays alone. These unusual associations present brand-new challenges to medical professionals.
In these cases, the medical detective work has a new aim: to understa...
Source: The Medical Futurist - November 28, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine digital health Healthcare technology AI Source Type: blogs
Applying Proteomics to the Development of Senolytic Therapies
We describe the technological advancements that have enabled researchers to address challenges inherent to the proteomic analysis of blood, such as the wide dynamic range of protein concentrations, and discuss multiple workflows that can be leveraged for the discovery of senescence biomarkers, senolytic targets, and cell-surface proteins. We also highlight how modern mass spectrometry-based technologies will open the door for future clinical applications, develop translationally relevant approaches to quantify aging and cellular senescence, and develop therapeutics for enhancing human healthspan. (Source: Fight Aging!)
Source: Fight Aging! - November 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Novel Mitophagy Inducing Compound
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis woul...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Aging Clock Derived from Images of the Lens of the Eye
In this study, we used informative lens photographs to generate LensAge as an innovative indicator to reveal aging status of lens based on deep learning (DL) models. Under ideal physiological conditions (both genetic and environmental), biological age should be synchronized with chronological age. While in reality, there are almost always differences between biological age and chronological age, which is considered to result from individually different aging processes. Therefore, we measured the difference between LensAge and chronological age as the LensAge index to assess an individual's aging rate relative to peers, and...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Semaglutide Use Reduces Heart Attack Incidence in Obese Individuals
Some interesting numbers for the effects of weight loss in obese individuals on risk of age-related disease arise from the use of semaglutide in clinical trials. In the study noted here, treated individuals lost 9% of body weight versus 1% for the placebo arm. The outcome of that is at least as good as the use of statins when it comes to effects on cardiovascular disease. The lesson to take away from this is likely that being overweight is more harmful than most people like to think that it is. Existing data is certainly supportive of that conclusion. Excess visceral fat tissue has been shown to lead to a shorter life expe...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Further Evidence for Reduced Blood Pressure to Lower Risk of Dementia
The raised blood pressure of hypertension causes a great deal of downstream damage. It is a way for low-level biochemical damage associated with aging to become actual physical damage to the body. Pressure damage can occur in delicate tissues throughout the body, and raised blood pressure increases the pace at which capillaries and other small vessels rupture. Further, increased blood pressure can accelerate the development of atherosclerosis, and also contributes to the pathological enlargement and weakening of heart muscle. All of this downstream harm is why forcing a reduction in blood pressure, without addressing any o...
Source: Fight Aging! - November 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why Oval shaped ASD device are not popular ?
This study , though addressed a vital query ,is never meant to find the truth we want, as it has no oval vs circular device to compare the outcome.
Final message
It is strange ,cardiologists look for perfection and precision in every cardiac intervention, … while in case of ASD device closure, size is sacrosanct, but shapes, we are allowed to shrug off. May be things will change.
Reference
1.Song J, Lee SY, Baek JS, Shim WS, Choi EY. Outcome of transcatheter closure of oval shaped atrial septal defect with amplatzer septal occluder. Yonsei Med J. 2013 Sep;54(5):1104-9.
2.Roberson DA, Cui W, Patel D, ...
Source: Dr.S.Venkatesan MD - November 21, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized amplatzer asd device ASD device closure asd device erosion asd ostium secundum size ivc rim vs aortic rim oval asd oval vs circular defects ovoid asd device size vs shape of asd Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Endothelial Cell Senescence in Atherosclerosis
Senescent cells accumulate throughout the body with age. They are created constantly due to stresses placed upon cells, and when somatic cells reach the Hayflick limit on replication, and are cleared by the immune system. This process of clearance slows down with age, unfortunately, and so a burden of lingering senescent cells begins to build up. Senescent cells are disruptive to tissue structure and function, even when present in comparatively small numbers relative to other cells in a tissue, as a result of the pro-growth, pro-inflammatory signals that they generate.
Atherosclerosis involves the generation of fatt...
Source: Fight Aging! - November 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cardiovascular Aging Correlates with Brain Aging
Many large epidemiological studies demonstrate a correlation between cardiovascular aging and the risk of suffering cognitive decline and dementia. The population size of such studies has increased in recent years with the advent of sizable national databases, such as the UK Biobank. Today's open access paper focuses on one specific aspect of cardiovascular aging, the onset of atrial fibrillation, irregular heartbeats that can be accompanied by palpitations and other worrying sensations. Atrial fibrillation can arise in combination with many of the features of cardiovascular aging, and one might argue that data on time of ...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Assessing Phenotypic Age Acceleration Differences by Lifestyle Choice
Phenotypic age is one of the less complicated biological age measures developed in recent years. As for all of the others, it was developed by using machine learning on a large set of human data, in this case commonly assessed blood biomarkers and their values at different ages. Thus while we know exactly what is being measured, it is an open question as to how those measurements relate to the underlying processes of aging, or indeed whether they accurately reflect all of those processes. Once one starts down the path of using lifestyle interventions to slow aging or novel therapies to repair the cell and tissue damage tha...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What does the angiogram show? The Echo? The CT coronary angiogram? How do you explain this?
A 70-something female with no previous cardiac history presented with acute chest pain. She awoke from sleep last night around 4:45 AM (3 hours prior to arrival) with pain that originated in her mid back. She stated the pain was achy/crampy. Over the course of the next hour, this pain turned into a pressure in her chest. She said this was midsternal and felt like a tightness. This originally radiated into her left arm. Over some time and the pain moved into her other arm as well as her jaw. She also had some shortness of breath. She was brought in by ambulance and re...
Source: Dr. Smith's ECG Blog - November 15, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Apple In Healthcare: How iPhone And Apple Watch Are Taking On Health
“I do think there will be a day when people looking back will say Apple’s greatest contribution to the world was healthcare.” this quote comes from the company’s CEO, Tim Cook, talking about Apple’s healthcare plans during the Time 100 Summit a while ago. This thought was repeated several times during the past years, but Apple seems to progress slowly, avoiding risks.
For its part, Apple entered the healthcare market later than its competitors but is working on acquiring a significant share of the market. Are the recent developments indicative of Tim Cook’s statement? Let’s see the steps that the compa...
Source: The Medical Futurist - November 14, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine Digital Health Research Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones EMR Deirdre Caldbeck fda AirPods iphone WSJ Apple Watch smartwatch Wall Street Journal Ce Source Type: blogs
Amyloid Aggregation in the Brain as a Driver of White Matter Hyperintensities
A white matter hyperintensity is a small areas of tissue damage in the brain, such as results from rupture of a small blood vessel and consequent bleeding. These areas of damage are readily visible in MRI scans, and their prevalence is known to correlate with loss of cognitive function and rising dementia risk. Here, researchers provide evidence to suggest that this process is primarily the result of amyloid-β aggregation in the brain rather than vascular aging processes.
Bright spots called white-matter hyperintensities (WMHs) often appear on MRI scans of people with familial or sporadic Alzheimer's disease (AD)...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
