In vivo evaluation of photodynamic inactivation using Photodithazine[registered sign]against Candida albicans
This study describes the photoinactivation of Candida albicans in a murine model of oral candidosis, mediated by Photodithazine[registered sign] (PDZ). Six-week-old female Swiss mice were immunosuppressed, and inoculated with C albicans...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)
Source: RSC - Photochem. Photobiol. Sci. latest articles - May 20, 2015 Category: Chemistry Authors: Ana Cl�udia Pavarina Source Type: research
Impact of short‐term exposure of antifungal agents on hemolysin activity of oral Candida dubliniensis isolates from Kuwait and Sri Lanka
ConclusionBrief exposure to sublethal concentrations of drugs with antifungal properties appears to reduce the pathogenic potential of C. dubliniensis isolates by suppressing hemolysin production. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - May 1, 2015 Category: Dentistry Authors: Arjuna N. B. Ellepola, J. A. M. Sumedha Jayathilake, Prem N. Sharma, Zia U. Khan Tags: Original Article Source Type: research
Positive Family History, Infection, Low Absolute Lymphocyte Count (ALC), and Absent Thymic Shadow: Diagnostic Clues for All Molecular Forms of Severe Combined Immunodeficiency (SCID)
Conclusions Infants with SCID appear normal at birth but later present with failure to thrive and/or recurrent fungal, viral, and bacterial infections. Low ALCs and an absent thymic shadow on chest x-ray are key diagnostic clues. The absence of T-cell function confirms the diagnosis. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 30, 2015 Category: Allergy & Immunology Source Type: research
Nanoparticles for controlled delivery and sustained release of chlorhexidine in the oral environment
ConclusionsChlorhexidine hexametaphosphate nanoparticles increased both the local dose and duration of soluble chlorhexidine delivery when applied to hydroxyapatite surfaces. This may provide a means to deliver a sustained dose of chlorhexidine with less frequent interventions.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
Source: Oral Diseases - February 20, 2015 Category: ENT & OMF Authors: Sarah Garner, Michele E Barbour Tags: Original Article Source Type: research
A novel Candida glabrata cell wall associated serine protease.
Abstract
We set out to identify the Candida glabrata cell wall attached proteases which may play a role as virulence factors in candidosis, particularly in the immunocompromized host. We studied a clinical C. glabrata strain T-1639, which was isolated from a patient from the Helsinki University Central Hospital. With non-reducing 2-D electrophoresis using parallel fluorogenic gels and mass spectrometry we identified a novel appr. 25 kDa (192 aa in length) cell wall located protease with an estimated pI of 7.6. The LC-MS/MS peptides matched with the ORF of predicted C. glabrata CBS138 cell wall protein Cwp...
Source: Biochemical and Biophysical Research communications - January 21, 2015 Category: Biochemistry Authors: Pärnänen P, Meurman JH, Nikula-Ijäs P Tags: Biochem Biophys Res Commun Source Type: research
In vitro anti-Candida activity of lidocaine and nitroglycerin: alone and combined.
In conclusion, both drugs exhibited an interesting anti-Candida activity. The combination of lidocaine with nitroglycerin was shown to have an additive effect against Candida spp., predicting the interest to include, in the future, these drugs in a new delivery system for the treatment of mucocutaneous candidosis.
PMID: 22675243 [PubMed - indexed for MEDLINE] (Source: Infectious Diseases in Obstetrics and Gynecology)
Source: Infectious Diseases in Obstetrics and Gynecology - November 18, 2014 Category: OBGYN Tags: Infect Dis Obstet Gynecol Source Type: research
Pathogenesis and treatment of oral candidosis.
Authors: Williams D, Lewis M
Abstract
Oral infections caused by yeast of the genus Candida and particularly Candida albicans (oral candidoses) have been recognised throughout recorded history. However, since the 1980s a clear surge of interest and associated research into these infections have occurred. This has largely been due to an increased incidence of oral candidosis over this period, primarily because of the escalation in HIV-infection and the AIDS epidemic. In addition, changes in medical practice leading to a greater use of invasive clinical procedures and a more widespread use of immunosuppressiv...
Source: Journal of Oral Microbiology - November 16, 2014 Category: Microbiology Tags: J Oral Microbiol Source Type: research
Influence of daily immersion in denture cleanser on multispecies biofilm
Conclusions
Daily exposure of a multispecies biofilm to a denture cleanser reduces the number of total microorganisms but favors C. albicans development.
Clinical relevance
Daily use of denture cleanser is an effective method for controlling bacteria in biofilm, but it can potentially select C. albicans, an important etiological agent of oral candidosis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 15, 2014 Category: Dentistry Source Type: research
Impact of brief and sequential exposure to nystatin, amphotericin B, ketoconazole, and fluconazole in modulating adhesion traits of oral Candida dubliniensis isolates
ConclusionsBrief and sequential exposure of C. dubliniensis to antifungal agents would continue to wield an antifungal effect by altering its adhesion attributes, and elucidate possible pharmacodynamics by which antifungal agents might operate in modulating candidal adherence. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 11, 2014 Category: Dentistry Authors: Arjuna N.B. Ellepola, Bobby K. Joseph, Lakshman P. Samaranayake, H.M.H.N. Bandara, Zia U. Khan Tags: Original Article Source Type: research
Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
Abstract
Opportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino group of this molecule. The aims of this study were to evaluate the antifungal effectiveness and host cell toxicity of these new compounds using an in vitro model of o...
Source: Medical Microbiology and Immunology - September 26, 2014 Category: Microbiology Source Type: research
Presence of Candida cell wall derived polysaccharides in the sera of intensive care unit patients: relation with candidaemia and Candida colonisation
Conclusion:
A combination of mannan and BDG tests could be used to guide pre-emptive therapeutic decisions in ICU patients. (Source: BioMed Central)
Source: BioMed Central - June 29, 2014 Category: Journals (General) Authors: Julien PoissyBoualem SendidSébastien DamiensKen Ichi IshibashiNadine FrançoisMarie KauvRaphaël FavoryDaniel MathieuDaniel Poulain Source Type: research
Detection of Candida albicans ADH1 and ADH2 mRNAs in human archival oral biopsy samples
ConclusionsCandida albicans was the predominant species in the lesions diagnosed as CHC, and the presence of C. albicans in CHC lesions was associated with a high expression of C. albicans ADH1 mRNA. There was no association between the presence of Candida and malignant transformation in the cases examined; however, the number of cases was limited and further studies are needed to further elucidate the role of C. albicans ADH1 in the pathogenesis of oral squamous cell carcinoma. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 14, 2014 Category: Pathology Authors: M. M. Bakri, R. D. Cannon, A. R. Holmes, A. M. Rich Tags: Original Article Source Type: research
Oral Budesonide as a Therapy for Protein‐Losing Enteropathy in Children After the Fontan Operation
ConclusionBudesonide can be used to treat protein‐losing enteropathy in selected patients with cardiac diseases. (Source: Journal of Cardiac Surgery)
Source: Journal of Cardiac Surgery - June 3, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Hazım Alper Gursu, Ilkay Erdogan, Birgul Varan, Ayla Oktay, Figen Ozcay, Murat Ozkan, Sait Aslamaci Tags: Perioperative Management Source Type: research
Post‐antifungal effect and adhesion to buccal epithelial cells of oral Candida dubliniensis isolates subsequent to limited exposure to amphotericin B, ketoconazole and fluconazole
ConclusionsBrief exposure to sub‐lethal concentrations of aforementioned drugs would exert an antifungal effect by modifying the growth and adhesion of C. dubliniensis isolates. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - May 22, 2014 Category: Dentistry Authors: Arjuna N. B. Ellepola, Rachel Chandy, Zia U. Khan Tags: Original Article Source Type: research
Anti-Candida activity of fluoxetine alone and combined with fluconazole - A synergistic action against fluconazole-resistant strains.
Abstract
The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against twenty-nine Candida strains isolated from vulvovaginal candidosis.MIC and MLC ranged from 9.8 to 625 μg/mL for all strains tested. The combination of fluconazole with fluoxetine resulted in a synergistic activity in six Candida strains with FIX between 0.15-0.31. An indifferent effect was found for the remaining strains with FIX between 0.63-1.
PMID: 24798281 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - May 5, 2014 Category: Microbiology Authors: Oliveira AS, Gaspar CA, Palmeira-de-Oliveira R, Martinez-de-Oliveira J, Palmeira-de-Oliveira A Tags: Antimicrob Agents Chemother Source Type: research
