Abnormal vaginal microbioma is associated with severity of localized provoked vulvodynia. Role of aerobic vaginitis and Candida in the pathogenesis of vulvodynia
AbstractLocalized provoked vulvodynia (LPV) causes introital dyspareunia in up to 14% of premenopausal women. Vaginal infections like candidosis may play a initiating role. The aim of this study was to test a possible association of vaginal microbiota alternations such asCandida vaginitis (CV), aerobic vaginitis (AV) and bacterial vaginosis (BV) with severity of vulvodynia and painful intercourse. In an observational study, Q-tip touch test (score 1 (no pain) to 10 (worst possible pain)) was performed on seven vestibular locations in 231 LPV patients presenting in the Vulvovaginal Disease Clinics in Tienen, Leuven and Antw...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 24, 2018 Category: Microbiology Source Type: research
Anti- Candida activity of antidepressants sertraline and fluoxetine: effect upon pre-formed biofilms
AbstractAs an opportunistic fungal pathogenCandida spp. has the ability to form biofilms. The most prescribed drugs forCandida infections, azoles, have shown to be less effective when biofilms are present. In addition, increasing treatment costs and the fact that most prescribed antifungal drugs have only fungistatic activity justify the search for new treatment strategies. One promising approach is third generation antidepressants, selective serotonin re-uptake inhibitors (SSRIs), because of their proven antifungal activity against severalCandida spp. Thus, the aim of this work was to determine the ability of two commonly...
Source: Medical Microbiology and Immunology - August 1, 2018 Category: Microbiology Source Type: research
The ReCiDiF method to treat recurrent vulvovaginal candidosis: A friend with benefits
Australian and New Zealand Journal of Obstetrics and Gynaecology,Volume 58, Issue 3, Page E5-E5, June 2018. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - June 4, 2018 Category: OBGYN Authors: Gilbert G. G. Donders
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Pedro Viera Baptista Source Type: research
Is Multiple Site Colonization with Candida spp. Related to Inadequate Response to Individualised Fluconazole Maintenance Therapy in Women with Recurrent Candida Vulvo-vaginitis?
Although most women on fluconazole maintenance therapy for recurrent vulvovaginal candidosis experience a substantial improvement in quality of life, some do not respond to therapy. Is candidal colonization of extragenital sites related to suboptimal response to maintenance therapy? (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - June 1, 2018 Category: Microbiology Authors: Gilbert GG Donders, Svitrigaile Grinceviciene, Gert Bellen, Kateryna Ruban Source Type: research
IL-23, IFN- α, and IFN-β in the vaginal fluid of patients suffering from vulvovaginal candidosis.
CONCLUSION: IL-23 and IEFN-β seem to play a protective role against VVC. Decreased levels in VVC patients suggest a compromised local immune response at the time of occurrence of symptoms. In contrast, IFN-α seems to be released once the infection has occurred. These cytokines may be prospective targets in the treatment and prevention of primary and recurrent vaginal infections with Candida species.
PMID: 29714856 [PubMed - in process] (Source: Clinical and Experimental Obstetrics and Gynecology)
Source: Clinical and Experimental Obstetrics and Gynecology - May 4, 2018 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Protein Content of Cervicovaginal Fluid Is Altered During Bacterial Vaginosis
Conclusions
Exclusive finding of BV affects immunity-related CVF components of reproductive-aged women. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - March 24, 2018 Category: OBGYN Tags: Original Research Articles: Vagina and Vulva Source Type: research
Anti- Candida activity of antidepressants sertraline and fluoxetine: effect upon pre-formed biofilms
AbstractAs an opportunistic fungal pathogenCandida spp. has the ability to form biofilms. The most prescribed drugs forCandida infections, azoles, have shown to be less effective when biofilms are present. In addition, increasing treatment costs and the fact that most prescribed antifungal drugs have only fungistatic activity justify the search for new treatment strategies. One promising approach is third generation antidepressants, selective serotonin re-uptake inhibitors (SSRIs), because of their proven antifungal activity against severalCandida spp. Thus, the aim of this work was to determine the ability of two commonly...
Source: Medical Microbiology and Immunology - March 19, 2018 Category: Microbiology Source Type: research
Evaluation of Candida Albicans biofilm formation on various parts of implant material surfaces
Conclusions: This finding emphasizes implant treatment would be chosen complacency in patients who are prone to oral candidosis, medically compromised patients under immunosuppression, and patients with tumor who are being treated with chemotherapy or radiation. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - February 6, 2018 Category: Rural Health Authors: C G & #246;kmeno & #287;lu NB Kara M Beld & #252;z A Kamburo & #287;lu & #304; Tosun E Sadik C Kara Source Type: research
Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey
AbstractA multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012 –2014. Samples were collected from 284 patients with invasive candidosis andCandida species isolated by culture. The species were identified by DNA sequencing and MALDI-TOF massspectrometry. A total of 322 isolates were recovered, in which 96% ofСandida species belonged to six major species, namely,C. albicans (43.2%),C. parapsilosis (20.2%),C. glabrata (11.5%),C. tropicalis (9.6%),C. krusei (6.2%), andC. guilliermondii (5.3%). MostCandida species were isolated from blood ...
Source: Frontiers of Medicine - January 16, 2018 Category: General Medicine Source Type: research
Interpretation of Nondiagnostic Vulvar Biopsies
ConclusionsNondiagnostic biopsies from the inner vulva should prompt thoughtful multidisciplinary review, but more research is required to resolve the problem of clinicopathologic discordance through better understanding of vulvar histology and pathophysiology.
Objective
The aim of the study was to assess clinical and histopathologic characteristics of symptomatic women who underwent a nondiagnostic biopsy of the inner vulva.
Materials and Methods
Consecutive nondiagnostic biopsies from medial labia minora, posterior fourchette, and vestibule obtained from symptomatic women between 2011 and 2015 were reviewed for th...
Source: Journal of Lower Genital Tract Disease - January 1, 2018 Category: OBGYN Tags: Original Research Articles: Vagina and Vulva Source Type: research
The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates
In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp. (four standard and 60 oral isolates) through minimum inhibitory concentration (MIC) and growth curve assays. Insight into the mechanisms of the antifungal action has been gained through ultrastructural studies using confocal scanning laser microscopy (CSLM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Molecular docking was done for predicting the interactions of magnolol with ergosterol at supramolecular level. The toxicity of magnolol on human erythrocytes was measured by in vitro hemolyt...
Source: Microbial Pathogenesis - November 19, 2017 Category: Infectious Diseases Source Type: research
A novel double-layer mucoadhesive tablet containing probiotic strain for vaginal administration: Design, development and technological evaluation.
Abstract
Vulvovaginal candidosis caused by Candida spp. is the most prevalent vaginal infection in Europe and the second one in EE.UU, so it has become a major female concern. Probiotics bacteria have been proposed as an alternative treatment with the aim of avoiding the adverse effects associated with conventional therapies including antibiotics and other aggressive drugs for the vaginal mucosa and microbiota. The purpose of this work was to design and develop a novel vaginal tablet that contained Lactobacillus spp. bacteria as a treatment against vulvovaginal infections. A total of 21 two-layers vaginal ...
Source: European Journal of Pharmaceutical Sciences - November 9, 2017 Category: Drugs & Pharmacology Authors: Sánchez MT, Ruiz MA, Castán H, Morales ME Tags: Eur J Pharm Sci Source Type: research
Anti- Candida activity of antimicrobial impregnated central venous catheters
ConclusionsAmong the recommended antimicrobial CVCs, CSS-CVCs proved to be superior in the inhibition of biofilm formation by the most frequent yeasts causing CLABSIs. Data from this in vitro study may suggest that patients at high risk for invasive candidosis could benefit from the use of CSS-CVCs. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - November 3, 2017 Category: Infectious Diseases Source Type: research
