Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research
Understanding and overcoming resistance to immunotherapy in genitourinary cancers
This article presents a comprehensive overview of the mechanisms of immunotherapy resistance in GU cancers as currently described in the literature. It explores studies that have identified genetic markers, cytokines, and proteins that may predict resistance or response to immunotherapy. Additionally, we review current efforts to overcome this resistance, which include combination ICIs and sequential therapies, novel insights into the host immune profile, and new targeted therapies. Various approaches that combine immunotherapy with chemotherapy, targeted therapy, vaccines, and radiation have been studied in an effort to m...
Source: Cancer Biology and Therapy - April 17, 2024 Category: Cancer & Oncology Authors: Sean T Evans Yash Jani Caroline S Jansen Ahmet Yildirim Ecem Kalemoglu Mehmet Asim Bilen Source Type: research
Identifying major histocompatibility complex class II-DR molecules in bovine and swine peripheral blood monocyte-derived macrophages using mAb-L243
This study used mAb-L243 to identify Staphylococcus aureus and Salmonella enterica serovar Typhimurium peptides binding to cattle and swine macrophage MHC-II-DR molecules using flow cytometry, mass spectrometry and two immunopurification techniques. Antibody cross-reactivity led to identifying expressed MHC-II-DR molecules, together with 10 Staphylococcus aureus peptides in cattle and 13 S. enterica serovar Typhimurium peptides in swine. Such data demonstrates that MHC-II-DR expression and immunocapture approaches using L243 mAb represents a viable strategy for flow cytometry and immunopeptidomics analysis of bovine and sw...
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Carmen Celis-Giraldo Diego Ordo ñez Diana D íaz-Arévalo Michel D Boh órquez Nieves Ibarrola Carlos F Su árez Kewin Rodr íguez Yoelis Yepes Alexander Rodr íguez Catalina Avenda ño Julio L ópez-Abán Ra úl Manzano-Román Manuel Alfonso Patarroyo Source Type: research
Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research
Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research
Intratumor injection of BCG Ag85A high-affinity peptides enhanced anti-tumor efficacy in PPD-positive melanoma
In conclusion, using the existing immune response of BCG vaccine by delivering high-affinity peptides of BCG to tumor area is a safe and promising therapy for cancer. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - April 17, 2024 Category: Cancer & Oncology Source Type: research
Recent advances in immunotherapies against infectious diseases
Immunother Adv. 2020 Nov 25;1(1):ltaa007. doi: 10.1093/immadv/ltaa007. eCollection 2021 Jan.ABSTRACTImmunotherapies are disease management strategies that target or manipulate components of the immune system. Infectious diseases pose a significant threat to human health as evidenced by countries continuing to grapple with several emerging and re-emerging diseases, the most recent global health threat being the SARS-CoV2 pandemic. As such, various immunotherapeutic approaches are increasingly being investigated as alternative therapies for infectious diseases, resulting in significant advances towards the uncovering of path...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Dharanidharan Ramamurthy Trishana Nundalall Sanele Cingo Neelakshi Mungra Maryam Karaan Krupa Naran Stefan Barth Source Type: research
Self-Assembled Recombinant Elastin and Globular Protein Vesicles with Tunable Properties for Diverse Applications
Acc Chem Res. 2024 Apr 16. doi: 10.1021/acs.accounts.3c00694. Online ahead of print.ABSTRACTConspectusVesicles are self-assembled structures comprised of a membrane-like exterior surrounding a hollow lumen with applications in drug delivery, artificial cells, and micro-bioreactors. Lipid or polymer vesicles are the most common and are made of lipids or polymers, respectively. They are highly useful structures for many applications but it can be challenging to decorate them with proteins or encapsulate proteins in them, owing to the use of organic solvent in their formation and the large size of proteins relative to lipid o...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Mikaela A Gray Mariela R Rodriguez-Otero Julie A Champion Source Type: research
Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development
CONCLUSION: HOTAIR, IDO1, KIF20A, NR5A2, and RRM2 were identified as promising candidate antigens for the development of an LGG mRNA vaccine, particularly offering potential benefits to FS2 and FS4 patients.PMID:38623558 | PMC:PMC11018127 | DOI:10.2147/PGPM.S449230 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zhenxiang Zhao Na Xing Hao Guo Jianfeng Li Guozhu Sun Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean J Radiol)
Source: Korean J Radiol - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Current knowledge on therapeutic, diagnostic, and prognostics applications of exosomes in multiple myeloma: opportunities and challenges
Arch Biochem Biophys. 2024 Apr 14:109994. doi: 10.1016/j.abb.2024.109994. Online ahead of print.ABSTRACTInteractions between the plasma cells and the BM microenvironment of Multiple myeloma (MM) take place through factors such as exosomes. Many studies have confirmed the role of exosomes in these interactions. By carrying proteins, cytokines, lipids, microRNAs, etc. as their cargo, exosomes can regulate the interactions between MM plasma cells and neighboring cells and participate in the signaling between cancer cells and the environment. It has been shown that MM-derived exosomes can induce angiogenesis, enhance osteoblas...
Source: Archives of Biochemistry and Biophysics - April 16, 2024 Category: Biochemistry Authors: Aghdas Ramezani Aida Tafazoli Fatemeh Salimi Mahlegha Ghavami Hanie Arjmandi Bahman Khalesi Zahra Sadat Hashemi Saeed Khalili Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Immunogenicity of quadrivalent human papillomavirus vaccine among Alaska Native children aged 9-14 years at 5 years after vaccination
CONCLUSIONS: Alaska Native children maintained antibodies against all 4vHPV types at 5 years post-vaccination.PMID:38627144 | DOI:10.1016/j.vaccine.2024.04.033 (Source: Vaccine)
Source: Vaccine - April 16, 2024 Category: Allergy & Immunology Authors: Bionca M Davis Ian Blake Gitika Panicker Elissa Meites Gail Thompson Jesse Geis Dana Bruden Marc Fischer Rosalyn Singleton Elizabeth R Unger Lauri E Markowitz Michael G Bruce Source Type: research
Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade
Adv Drug Deliv Rev. 2024 Apr 14:115306. doi: 10.1016/j.addr.2024.115306. Online ahead of print.ABSTRACTCancer immunotherapy represents a revolutionary strategy, leveraging the patient's immune system to inhibit tumor growth and alleviate the immunosuppressive effects of the tumor microenvironment (TME). The recent emergence of immune checkpoint blockade (ICB) therapies, particularly following the first approval of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors like ipilimumab, has led to significant growth in cancer immunotherapy. The extensive explorations on diverse immune checkpoint antibodies have broa...
Source: Advanced Drug Delivery Reviews - April 16, 2024 Category: Drugs & Pharmacology Authors: Youngjin Choi Su Hyun Seok Hong Yeol Yoon Ju Hee Ryu Ick Chan Kwon Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean J Radiol)
Source: Korean J Radiol - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
