Oligonucleotide based nanogels for cancer therapeutics
Int J Biol Macromol. 2024 Apr 4:131401. doi: 10.1016/j.ijbiomac.2024.131401. Online ahead of print.ABSTRACTOligonucleotide-based nanogels, as nascent biomaterials, possess several unique functional, structural, and physicochemical features with excellent drug-loading capacity and high potential for cancer gene therapy. Ongoing studies utilizing oligonucleotide-based nanogels hold great promise, as these cutting-edge nanoplatforms can be elegantly developed with predesigned oligonucleotide sequences and complementary strands which are self-assembled or chemically crosslinked leading to the development of nanogels with predi...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Hooman Hatami Niloufar Rahiman Marzieh Mohammadi Source Type: research
Role of immunotherapies and stem cell therapy in the management of liver cancer: A comprehensive review
Int Immunopharmacol. 2024 Apr 5;132:112011. doi: 10.1016/j.intimp.2024.112011. Online ahead of print.ABSTRACTLiver cancer (LC) is the sixth most common disease and the third most common cause of cancer-related mortality. The WHO predicts that more than 1 million deaths will occur from LC by 2030. Hepatocellular carcinoma (HCC) is a common form of primary LC. Today, the management of LC involves multiple disciplines, and multimodal therapy is typically selected on an individual basis, considering the intricate interactions between the patient's overall health, the stage of the tumor, and the degree of underlying liver disea...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Fares E M Ali Islam M Ibrahim Hanan S Althagafy Emad H M Hassanein Source Type: research
Oligonucleotide based nanogels for cancer therapeutics
Int J Biol Macromol. 2024 Apr 4:131401. doi: 10.1016/j.ijbiomac.2024.131401. Online ahead of print.ABSTRACTOligonucleotide-based nanogels, as nascent biomaterials, possess several unique functional, structural, and physicochemical features with excellent drug-loading capacity and high potential for cancer gene therapy. Ongoing studies utilizing oligonucleotide-based nanogels hold great promise, as these cutting-edge nanoplatforms can be elegantly developed with predesigned oligonucleotide sequences and complementary strands which are self-assembled or chemically crosslinked leading to the development of nanogels with predi...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Hooman Hatami Niloufar Rahiman Marzieh Mohammadi Source Type: research
Increasing Rates of Human Papillomavirus Catch ‐Up Vaccination at a Sexual and Reproductive Health Clinic: A Quality Improvement Project
DiscussionRates of catch-up HPV vaccination increased significantly following the multicomponent, systems-based intervention. Further iteration of the quality improvement process should examine the sustainability of the interventions and the effects of the intervention on vaccine series completion. (Source: Journal of Midwifery and Women's Health)
Source: Journal of Midwifery and Women's Health - April 5, 2024 Category: Midwifery Authors: C. Shannon Pfingstag Tags: Quality Improvement Source Type: research
Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents
World J Hepatol. 2024 Mar 27;16(3):331-343. doi: 10.4254/wjh.v16.i3.331.ABSTRACTChronic hepatitis B virus (HBV) infection affects over 295 million people globally and an estimated 1.6 million people in the United States. It is associated with significant morbidity and mortality due to cirrhosis, liver failure, and liver cancer. Antiviral therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression, which in turn has been associated with a decreased risk of liver complications. However, current antiviral regimens are limited by concerns with adverse effects, adherence, resistance, long-te...
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Robert Lam Joseph K Lim Source Type: research
Depletion of Regulatory T Cells Enhancing the Anti-tumor Effect of in situ Vaccination in solid tumors
In this study, immune stimulating agent unmethylated CG-enriched (CpG) oligodeoxynucleotide (ODN) was locally injected into the tumor to trigger a robust immune response to eradicate cancer cells, while anti-CD25 antibody was applied to remove immunosuppressive regulatory T cells, which further enhanced the host immune activity to attack tumor systematically. The combination of CpG and anti-CD25 antibody obtained notable regression in mouse melanoma model. Furthermore, rechallenge of tumor cells in the xenograft model has resulted in smaller tumor volume, which demonstrated that the combinational treatment enhanced the act...
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Ya-Jia Xie Sha Tian Min Huang Lin-Lin Lu Zhong-Qiu Liu Jun-Hui Chen Xing-Xing Fan Source Type: research
Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents
World J Hepatol. 2024 Mar 27;16(3):331-343. doi: 10.4254/wjh.v16.i3.331.ABSTRACTChronic hepatitis B virus (HBV) infection affects over 295 million people globally and an estimated 1.6 million people in the United States. It is associated with significant morbidity and mortality due to cirrhosis, liver failure, and liver cancer. Antiviral therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression, which in turn has been associated with a decreased risk of liver complications. However, current antiviral regimens are limited by concerns with adverse effects, adherence, resistance, long-te...
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Robert Lam Joseph K Lim Source Type: research
Depletion of Regulatory T Cells Enhancing the Anti-tumor Effect of in situ Vaccination in solid tumors
In this study, immune stimulating agent unmethylated CG-enriched (CpG) oligodeoxynucleotide (ODN) was locally injected into the tumor to trigger a robust immune response to eradicate cancer cells, while anti-CD25 antibody was applied to remove immunosuppressive regulatory T cells, which further enhanced the host immune activity to attack tumor systematically. The combination of CpG and anti-CD25 antibody obtained notable regression in mouse melanoma model. Furthermore, rechallenge of tumor cells in the xenograft model has resulted in smaller tumor volume, which demonstrated that the combinational treatment enhanced the act...
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Ya-Jia Xie Sha Tian Min Huang Lin-Lin Lu Zhong-Qiu Liu Jun-Hui Chen Xing-Xing Fan Source Type: research
Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents
World J Hepatol. 2024 Mar 27;16(3):331-343. doi: 10.4254/wjh.v16.i3.331.ABSTRACTChronic hepatitis B virus (HBV) infection affects over 295 million people globally and an estimated 1.6 million people in the United States. It is associated with significant morbidity and mortality due to cirrhosis, liver failure, and liver cancer. Antiviral therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression, which in turn has been associated with a decreased risk of liver complications. However, current antiviral regimens are limited by concerns with adverse effects, adherence, resistance, long-te...
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Robert Lam Joseph K Lim Source Type: research
