Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Three Ways AI, If Trusted, Can Transform the Healthcare Landscape
The following is a guest article by Jeanne Greathouse, Healthcare Development Director, AI Regulatory Services at BSI
77% of Healthcare Workers Say They May Be Ready to Let AI Take on Administrative Work
Few industries have been stress-tested as thoroughly as the healthcare system during COVID-19 when, at the worst moments, 22% of US hospitals were reporting staff shortages. Even three years on, the World Health Organization found that 84% of countries were still experiencing some disruption. Amid a period of tremendous medical uncertainty and service disruption, health workers and first responders functioned like a life v...
Source: EMR and HIPAA - March 15, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Artificial Intelligence BSI Healthcare Efficiency Healthcare Transformation Improving Patient Care Jeanne Greathouse Medical Innovation Source Type: blogs
Electronic Health Records (EHR): How to Achieve Healthcare Data Accuracy with Artificial Intelligence
The following is a guest article by Ann Krutsko, Healthcare IT Researcher at ScienceSoft
In healthcare, working with inaccurate patient data is a dangerous game. Electronic Health Records (EHRs) were designed to streamline operations and improve coordination across healthcare systems. And while EHRs have largely benefited the organizations that have adopted them, data accuracy is still a point of concern. Data entry is still fraught with human error. However, innovations in the field in the way of artificial intelligence integrations are making significant strides in enhancing data quality in EHRs. From data validation to ...
Source: EMR and HIPAA - March 6, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data Health IT Company Healthcare IT AI Integration Ann Krutsko Data Accuracy Data Entry Data Validation EHR Healthcare AI Healthcare Data Real-Time Alerts ScienceSoft Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
« Back to Top
Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on Kimer Med, Improving on the DRACO Antiviral Technology and Moving Towards the Clinic
The state of anti-viral therapies isn't that great, all things considered. Technology has not yet advanced to the point at which a viral infection can be simply shut down, as is the case for near all bacterial infections. The present anti-viral drugs are either vaccines (useful!) or merely shift the odds somewhat by interfering in some part of the viral life cycle, but nowhere near as effectively as desired. Many persistent viral infections are thought to contribute meaningfully to forms of age-related dysfunction, and there is too little that can be done about that at the present time.
This landscape is one of the ...
Source: Fight Aging! - February 23, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
This Looks Like Rather Good News On The Cancer Front!
This encouraging report appeared a few days ago. Australian researchers unlock the secret to a future cancer vaccine Exclusive By Natasha Robinson Health Editor 3:00AM February 15, 2024 Australian researchers have unlocked a crucial key to future cancer vaccines in a world-first discovery set to fast-track RNA-based therapeutics. Vaccine technology took a giant leap forward with the advent of (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - February 20, 2024 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Breakthroughs in liver cancer treatment [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We sit down with health care executive Eugene Chan to explore the rising rates of liver cancer worldwide and the potential game-changer in its treatment: monoclonal antibodies. Join us as we delve into the factors contributing to liver cancer’s prevalence, the impact of vaccination,
Read more…
Breakthroughs in liver cancer treatment [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 17, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Oncology/Hematology Source Type: blogs
Who Could (Possibly) Be the Ideal “ Chief Patient Officer ” ? (And Other Ideas that Sound Better on Paper than in Practice)
By JONATHON S. FEIT
If ideas presented in essays on The Health Care Blog and other healthcare forums are meant to be rhetorical, without intention of turning notions into reality on behalf of patients who need genuine, intimate, desperate help…then feel free to ignore this essay entirely.
Some among us—the State of Washington’s Co-Responder Outreach Alliance; Lisa Fitzpatrick’s Grapevine Health, which specializes in “street medicine” and advocacy in and around Washington, D.C.; Thorne Ambulance Service, an inspirational ambulance entrepreneur bringing both emergency and nonemergency medical transpor...
Source: The Health Care Blog - January 26, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health Tech Chief Patient Officer CIVITAS EMS First Responders Interoperability Jonathan Feit Kat McDavitt Lisa Bari Medicaid Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
RISE-ing Stars From Northern Arizona University
Chantel Tsosie at her college graduation, wearing her Tribe’s formal, traditional rug dress that her grandmother made. Credit: Courtesy of Chantel Tsosie.
“Science is for everyone. It’s in everything. It exists in cultures everywhere,” says Chantel Tsosie, a master’s student in the NIGMS-supported Research Initiative for Scientific Enhancement (RISE) program at Northern Arizona University (NAU) in Flagstaff. The program aims to prepare a diverse group of students for research careers through culturally relevant support, hands-on research experiences, and a tailored curriculum.
Chantel started her bachelor’...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 10, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
The 6 Most Exciting Medical Technology Breakthroughs Of Recent Years
Amidst the flurry of hyped technologies, it’s not easy to pinpoint which specific technological breakthroughs will have the most impact in the coming years.
Dr. Meskó, The Medical Futurist, reviews multiple reports, studies, and articles daily. Consequently, our days are filled with awe-inspiring developments. However, our aim here is to offer more than just a compilation of “wow, look how fascinating” stories.
To achieve this, we have selected technologies that:
Have undergone significant breakthroughs in recent years, be it in regulatory, technological, or scientific aspects
Are anticipate...
Source: The Medical Futurist - January 9, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health future Healthcare Source Type: blogs
How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
