Immunocompromised individuals are at increased risk of COVID ‐19 breakthrough infection, hospitalization, and death in the post‐vaccination era: A systematic review
ConclusionThis demonstrated that vaccination does not offer an adequate level of protection in these groups, necessitating further measures such as Evusheld and further boosters. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 26, 2024 Category: Allergy & Immunology Authors: Jola Bytyci,
Yuxin Ying,
Lennard Y. W. Lee Tags: REVIEW ARTICLE Source Type: research
Viruses, Vol. 16, Pages 680: Human Papillomavirus and Associated Cancers: A Review
Rysavy
The human papillomavirus is the most common sexually transmitted infection in the world. Most HPV infections clear spontaneously within 2 years of infection; however, persistent infection can result in a wide array of diseases, ranging from genital warts to cancer. Most cases of cervical, anal, and oropharyngeal cancers are due to HPV infection, with cervical cancer being one of the leading causes of cancer death in women worldwide. Screening is available for HPV and cervical cancer, but is not available everywhere, particularly in lower-resource settings. HPV infection disproportionally affects individuals liv...
Source: Viruses - April 26, 2024 Category: Virology Authors: JaNiese E. Jensen Greta L. Becker J. Brooks Jackson Mary B. Rysavy Tags: Review Source Type: research
Cervical Cancer Stigma Among Caribbean Population: A Descriptive Paper
Conclusion: Cancer stigma of cervical cancer exists in Jamaica, Trinidad and Tobago, and Grenada. Particularly, cultural background and social norms are closely linked to stigma.PMID:38660496 | PMC:PMC11039822 | DOI:10.3389/ijph.2024.1606725 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Kamilah Thomas-Purcell Althea Bailey Diadrey-Anne Sealy Gaole Song Kimlin Tam Ashing Source Type: research
Medical students' knowledge about human papillomavirus (HPV), HPV vaccine and head and neck cancer
Hum Vaccin Immunother. 2024 Dec 31;20(1):2344248. doi: 10.1080/21645515.2024.2344248. Epub 2024 Apr 24.ABSTRACTThe Human Papillomavirus (HPV) is a sexually transmitted infection that significantly affects the population worldwide. HPV preventive methods include vaccination, prophylactics, and education. Different types of cancers associated with HPV usually take years or decades to develop after infections, such as Head and Neck Cancer(HNC). Therefore, HPV prevention can be considered cancer prevention. A sample of medical students in Puerto Rico was evaluated to assess their knowledge about HPV, HPV vaccine, and HNC throu...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Norangelys Solis-Torres Isardo Braverman-Diaz Luis A Rivera-Morales Jose J Perez-Sanchez Valeria S Perez-Bravo Angel J Neris-Sanchez Alexis Vera Yaritza Diaz-Algorri Source Type: research
Medical students ’ knowledge about human papillomavirus (HPV), HPV vaccine and head and neck cancer
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 25, 2024 Category: Allergy & Immunology Authors: Norangelys Solis-TorresIsardo Braverman-DiazLuis A. Rivera-MoralesJose J. Perez-SanchezValeria S. Perez-BravoAngel J. Neris-SanchezAlexis VeraYaritza Diaz-AlgorriMaster of Public Health Program, San Juan Bautista School of Medicine, Caguas, Puerto Rico Source Type: research
Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
Rev Inst Med Trop Sao Paulo. 2024 Apr 19;66:e24. doi: 10.1590/S1678-9946202466024. eCollection 2024.ABSTRACTInactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses with...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Karim Yaqub Ibrahim Raquel Megale Moreira Carolina Ferreira Dos Santos T ânia Mara Varejão Strabelli Juliana de C ássia Belizário Maria Isabel de Moraes Pinto Ana Karolina Barreto Berselli Marinho Juliana Marquezi Pereira Liliane Saraiva de Mello Maur Source Type: research
Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination
CONCLUSIONS: This study successfully demonstrated that C. butyricum and C. sporogenes can produce the two recombinant antigen proteins (NY-ESO-1 and SARS-CoV-2-related Spike_S1 antigens) through genetic manipulations, utilizing the AUU start codon. This approach overcomes challenges in cloning difficult proteins in E. coli. These findings underscore the feasibility of harnessing commensal clostridia for antigen protein secretion, emphasizing the applicability of non-canonical translation initiation across diverse species with broad implications for medical or industrial biotechnology.PMID:38659027 | DOI:10.1186/s12934-024-...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Yanchao Zhang Tom S Bailey Philip Hittmeyer Ludwig J Dubois Jan Theys Philippe Lambin Source Type: research
A comprehensive synthetic library of poly-N-acetyl glucosamines enabled vaccine against lethal challenges of Staphylococcus aureus
Nat Commun. 2024 Apr 24;15(1):3420. doi: 10.1038/s41467-024-47457-4.ABSTRACTPoly-β-(1-6)-N-acetylglucosamine (PNAG) is an important vaccine target, expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that the impacts of the number and the position of free amine vs N-acetylation on its antigenicity are not well understood. In this work, a divergent strategy is developed to synthesize a comprehensive library of 32 PNAG pentasaccharides. This library enables the identification of PNAG sequences with specific patterns of free amines as epitopes for vaccines against Staphylococcus aureus (S. aure...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Zibin Tan Weizhun Yang Nicholas A O'Brien Xingling Pan Sherif Ramadan Terence Marsh Neal Hammer Colette Cywes-Bentley Mariana Vinacur Gerald B Pier Jeffrey C Gildersleeve Xuefei Huang Source Type: research
Pursuance of a Yoruba name for cervical cancer in Southwest Nigeria: a case study
CONCLUSIONS: There was no consensus Yoruba name for cervical cancer among the study participants. Efforts to educate the Yoruba speaking populace about cervical cancer, its prevention, management and participation in its research can be frustrated if a generally accepted Yoruba name is not provided for this cancer. Stakeholders' collaboration is required to get an appropriate Yoruba name for cervical cancer.PMID:38658005 | DOI:10.1136/bmjopen-2023-074020 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Folusho Mubowale Balogun Olayemi Omotade Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
CONCLUSIONS: The HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe.PMID:38656653 | DOI:10.1007/s40121-024-00963-w (Source: Herpes)
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Alen Marijam Nikki Vroom Amit Bhavsar Inga Posiuniene Nicolas Lecrenier Hilde Vroling Source Type: research
Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
Rev Inst Med Trop Sao Paulo. 2024 Apr 19;66:e24. doi: 10.1590/S1678-9946202466024. eCollection 2024.ABSTRACTInactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses with...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Karim Yaqub Ibrahim Raquel Megale Moreira Carolina Ferreira Dos Santos T ânia Mara Varejão Strabelli Juliana de C ássia Belizário Maria Isabel de Moraes Pinto Ana Karolina Barreto Berselli Marinho Juliana Marquezi Pereira Liliane Saraiva de Mello Maur Source Type: research
GSE256478 The efficacy of LCMV-based cancer vaccines is unleashed by intratumoral injections of polyI:C (II)
Conclusion Intratumoral injection of poly(I:C) sensitizes MHClow tumors to the anti-tumor effects of artLCMV-E7E6, resulting in a potent therapeutic synergy (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE245436 The efficacy of LCMV-based cancer vaccines is unleashed by intratumoral injections of polyI:C
Conclusion Intratumoral injection of poly(I:C) sensitizes MHClow tumors to the anti-tumor effects of artLCMV-E7E6, resulting in a potent therapeutic synergy (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Cancers, Vol. 16, Pages 1629: Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions
We report on identified multimarker panels of serum proteomic studies in CC for the past 5 years, the potential for modern computational biology efforts, and the utilization of nationwide biobanks to bridge the gap between multivariate protein signature development and the prediction of clinically relevant CC patient outcomes. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Chaston Weaver Alisha Nam Caitlin Settle Madelyn Overton Maya Giddens Katherine P. Richardson Rachael Piver David P. Mysona Bunja Rungruang Sharad Ghamande Richard McIndoe Sharad Purohit Tags: Review Source Type: research
Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination
Clostridium spp. has demonstrated therapeutic potential in cancer treatment through intravenous or intratumoral administration. This approach has expanded to include non-pathogenic clostridia for the treatment of... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 24, 2024 Category: Microbiology Authors: Yanchao Zhang, Tom S. Bailey, Philip Hittmeyer, Ludwig J. Dubois, Jan Theys and Philippe Lambin Tags: Research Source Type: research
