2024 Kuan-Teh Jeang Memorial Lecture: The broad impact of innate immune receptors in viral infection, cancer and autoimmunity
Jenny Pan-Yun Ting is a Taiwanese-American immunologist and microbiologist at University of North Carolina. She is a highly cited researcher who studies the role of NLR genes in regulating inflammation and how nanoparticles and microparticles can be used as vaccine adjuvants. In memory of Kuan-Teh Jeang, the lecture will discuss the roles of multiple innate immune receptors in viral infection in mouse models and patients. The seminar will also describe the unexpected intrinsic roles of these receptors in adaptive T and B lymphocytes. The latter adects both cancer and autoimmunity, with implications for immunotherapeutics.I...
Source: Videocast - All Events - April 17, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Kuan-Teh Jeang Memorial Lecture: The broad impact of innate immune receptors in viral infection, cancer and autoimmunity
Jenny Pan-Yun Ting is a Taiwanese-American immunologist and microbiologist at University of North Carolina. She is a highly cited researcher who studies the role of NLR genes in regulating inflammation and how nanoparticles and microparticles can be used as vaccine adjuvants. In memory of Kuan-Teh Jeang, the lecture will discuss the roles ofmultiple innate immune receptors in viral infection in mouse models and patients. Theseminar will also describe the unexpected intrinsic roles of these receptors in adaptive Tand B lymphocytes. The latter adects both cancer and autoimmunity, with implications forimmunotherapeutics.For m...
Source: Videocast - All Events - April 3, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH ProtIG seminar: Immunopeptidomics Frontier: Practical Deployments Today, Revolutionary Visions Tomorrow
The science that investigates the ensembles of all peptides associated with human leukocyte antigen (HLA) molecules is termed " immunopeptidomics " and is typically driven by mass spectrometry (MS) technologies. Recent advances in MS technologies, neoantigen discovery, and cancer immunotherapy have catalyzed the launch of the Human Immunopeptidome Project with the goal of providing a complete map of the human immunopeptidome and making the technology so robust that it will be available in every clinic. In this presentation, I will describe our latest progress in the field for the discovery of tumor-specific antigens and vi...
Source: Videocast - All Events - March 20, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - IL-27: King of Cytokines
Cytokines are not inherently pro- or anti-inflammatory and the Hunter laboratory is interested in how these factors govern the development of immunity to infection but can also be involved in the prevention of immune hyperactivity. The presentation will cover the immunobiology of the cytokine IL-27, its ability to limit infection-induced pathological T cell and monocyte responses and how this pathway can be targeted as a cancer therapy. The knowledge of the biology of IL-27 can also be used to inform strategies to enhance mRNA vaccination.Air date: 4/3/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 18, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: Harnessing Innate Immunity and Inflammasome Activation in Vaccines and Cancer Therapy
The IIG Seminar Series consists of invited speakers speaking on topics of great interest to the immunology community at the NIH and FDA. Each year, intramural and extramural speakers are chosen and invited by the IIG Steering Committee.Air date: 2/7/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 18, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: NIH/FDA - Tobias Hohl
All people encounter, inhale, and ingest fungi on a daily basis. Although only several hundred of the estimated five million species of fungi worldwide cause disease in humans, advances in medical technologies and the global AIDS pandemic have dramatically increased our susceptibility to fungal disease. In cancer and bone marrow transplant patients, the filamentous mold Aspergillus fumigatus and the commensal fungus Candida albicans represent significant causes of infection-related morbidity and mortality. At present, no fungal vaccines have been licensed for clinical use, and contemporary antifungal therapies for systemic...
Source: Videocast - All Events - March 3, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - The tumor antigenic landscape associated with T cell infiltration and immunoediting.
The Bassani-Sternberg lab focuses on identifying clinically relevant cancer-specific Human Leukocyte Antigen (HLA) ligands that will guide the development of personalized cancer immunotherapy using mass-spectrometry (MS), currently the only methodology to identify unbiasedly HLA binding peptides that are presented in vivo to cytotoxic T cells. Her group has developed proteogenomics and MS-based immunopeptidomics analytical and computational approaches to identify HLA ligands derived from tumor-associated proteins, mutated neoantigens, non-canonical ORFs and post translationally modified peptides. In the clinic, the Bassani...
Source: Videocast - All Events - March 1, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine - Human Papilloma Virus (HPV) Vaccination and the Prevention of Cancer
The Demystifying Medicine Series, jointly sponsored by FAES and NIH, includes presentations on pathology, diagnosis, and therapy in the context of major disease problems and current research. Primarily directed toward PhD students, clinicians and program managers, this series is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, trainees, fellows, and staff are welcome to participate.For more information go tohttps://demystifyingmedicine.od.nih.gov/Air date: ...
Source: Videocast - All Events - January 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group 1.11.23
Klaus Fr ü h ’ s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown protection in non-human primate models of AID...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Combination Immunotherapy in HPV Associated Malignancies and Other Solid Tumors
CCR Grand Rounds
Dr. Strauss received his M.D. from Stony Brook University Medical Center School of Medicine in 2010 and completed his internal medicine residency at Montefiore Medical Center in 2013. He joined the NCI Medical Oncology Service as a Medical Oncology Fellow in 2013. Dr. Strauss was the Co-Director o f the Clinical Trials Group of the Laboratory of Tumor Immunology and Biology, NCI. He is currently the Clinical Director of CIO Combination Immunotherapy Group. He is board certified in medical oncology and internal medicine. Dr. Strauss was part of the larger effort of the Laboratory of Tumor Immu nology and B...
Source: Videocast - All Events - November 17, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Molecular Medicine in the War on Cancer: Success or Failure?
Office of NIH History Lecture Series
A virologist is among the luckiest of biologists because he can see into his chosen pet down to the details of all of its molecules. ” --David Baltimore, 1975. Accepting his Nobel Prize for his part in the identification of reverse transcriptase, David Baltimore reflected on the “ luck ” that virologists enjoyed in their ability to see into problems with molecular precision. Although this vision seems inspiring and compelling today, Baltimore spoke at a time of fierce debate among biologists, legislators, and clinicians as to what, if anything, this molecular approach to disease o...
Source: Videocast - All Events - November 22, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Protective and Pathogenic B Cell Responses: COVID-19 and Autoimmunity
Dr. Sanz's research interest is in understanding how the immune system goes awry in autoimmune diseases and ends up attacking our own tissues rather than concentrating on fighting infections. In particular, he is very interested in understanding the roles played in autoimmune diseases by B cells and their effector progeny, the plasma cells responsible for producing the autoantibodies that in many cases cause the disease. His research concentrates on systemic lupus erythematosus, but he is also investigating other autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis and type 1 diabetes. His work also has app...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
2020 NIH Rural Health Seminar
Today, approximately 20% of the U.S. population — about 60 million people — live in rural areas, which make up 97% of the land area in the United States. People living in rural America have less access to health care and are more likely than residents of urban areas to die from chronic conditions such as heart disease, cancer, stroke, and chronic lower respiratory disease. Moreover, long-standing systemic health and social inequities have put many rural residents at increased risk of getting COVID-19. The rural/urban inequities in health and health care warrant more rigorous and innovative scientific research to improv...
Source: Videocast - All Events - September 23, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
The Case for BK Polyomavirus as a Cause of Bladder Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Buck ’ s lab studies polyomaviruses. A great majority of healthy adults chronically shed
polyomavirus virions in their urine and from the surface of their skin. Although these lifelong infections generally aren't known to cause symptoms in healthy individuals, under conditions of immune impairment polyomaviruses can cause disease. For example, BK polyomavirus (BKV) causes kidney and bladder damage in organ transplant patients, while its close relative JCV causes a lethal brain disease in patients on immunosuppressive therapies and in individuals suffering from ...
Source: Videocast - All Events - March 2, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
