Molecular engineering of immunotherapeutics: from regulation in autoimmunity to immunity to cancer
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Hubbell uses biomaterials and protein engineering approaches to investigate topics in regenerative medicine and immunotherapeutics. In regenerative medicine, he focuses on biomaterial matrices that mimic the extracellular matrix and on growth factor - extracellular matrix interactions, working in a variety of animal models of regenerative medicine. In immunotherapeutics, he focuses on nanomaterials in vaccines that target lymphoid-resident antigen presenting cells and on protein engineering approaches to deliver antigen to the spleen and liver for inverse vaccines t...
Source: Videocast - All Events - January 7, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Advances in Cancer Prevention Lecture 2018: Successes and Challenges of Vaccines to Prevent HPV-associated Cancers
The Annual Advances in Cancer Prevention Lecture is sponsored by the Cancer Prevention Fellowship Program (CPFP) within the Division of Cancer Prevention (DCP) at NCI. It is also part of the course offerings of the annual NCI Summer Curriculum in Cancer Prevention, but is open to the entire NIH community and general public. This annual lecture addresses current challenges and/or approaches used by investigators to address gaps, advance science, and promote the application of successful strategies in the field of cancer prevention and control. NIH Distinguished Investigator and Deputy Chief of the Laboratory of Cellular Onc...
Source: Videocast - All Events - May 24, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
T Cell Memory and Exhaustion
Immunonology IG Seminar
Dr. Rafi Ahmed is the Georgia Research Alliance Professor of Microbiology and Immunology, and Director of the Emory Vaccine Center at Emory University School of Medicine in Atlanta, GA. His research efforts are directed towards: 1. Understanding the mechanisms of immunological memory and using this knowledge to develop new and more effective vaccines. 2. Defining the mechanisms of T cell exhaustion during chronic viral infections and cancer and developing strategies for restoring function in exhausted T cells. Dr. Ahmed is a member of the National Academy of Sciences and the National Academy of Medi...
Source: Videocast - All Events - April 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Mechanistic basis of cancer immunotherapy
NIH Director's Wednesday Afternoon Lecture Series
My group ’ s long interest in understanding the cellular mechanisms of the immune response has increasingly focused on the problem of cancer immunology and immunotherapy. We have now established an entire department devoted to this effort, and postdocs in my group seek to understand how checkpoint inhibitors (eg anti-PD-L1), vaccines, immune agonists and their combinations work to produce durable anti-cancer responses.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/18/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
HPV VLPs: Nature ’ s Nanoparticles for Prevention and Treatment of Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. John Schiller graduated from the University of Wisconsin-Madison with a B.S. in molecular biology in 1975. In 1982, he received a Ph.D. from the Department of Microbiology of the University of Washington in Seattle, then joined the NCI Laboratory of Cellular Oncology as a National Research Service Award postdoctoral fellow in 1983. Dr. Schiller became a senior staff fellow in the Laboratory of Cellular Oncology in 1986 and a senior investigator in 1992. He became chief of the Neoplastic Disease Section of the lab in 1998, deputy lab chief in 2000 and designated as...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer Immunology and Immunotherapy: From Conception to Delivery (Day 2)
This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and immunology and immunotherapy.
Sessions will include:
-Fundamentals of CAR-based Therapies I& II-The Basis of Tumor Recognition-Checkpoint Modulators-Fundamental Biology of T Lymphocytes-Cancer Vaccines and Their ContextFor more information go tohttps://ncifrederick.cancer.gov/events/CancerImmunology2017/default.aspAir date: 10/13/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer Immunology and Immunotherapy: From Conception to Delivery (Day 1)
This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and immunology and immunotherapy.
Sessions will include:
-Fundamentals of CAR-based Therapies I& II-The Basis of Tumor Recognition-Checkpoint Modulators-Fundamental Biology of T Lymphocytes-Cancer Vaccines and Their ContextFor more information go tohttps://ncifrederick.cancer.gov/events/CancerImmunology2017/default.aspAir date: 10/12/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Abscopal Effect: Optimal Radiation Dose and Fractionation
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Formenti is the Chair of Radiation Oncology at Weill Cornell Medical College and the Associate Director of the Cancer Center. Trained as a medical and radiation oncologist she devoted her career to translate novel preclinical information to the clinic. Key to her formation was a year spent in Malcolm Mitchell ’ s laboratory at USC, in cancer immunology. Her initial research on how to best combine radiation and systemic therapy, both pre-clinically and clinically evolved on focusing on the systemic effects of radiotherapy, particularly on the immune system. Her l...
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series
The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell –...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The changing epidemiology of HPV and cervical cancer: from etiology, to validation of prevention methods, to dissemination
NIH Director's Wednesday Afternoon Lecture Series
Over three decades of studies moving from etiology to preventive methods research to guidelines development, Dr. Schiffman has learned some broad lessons about the strengths and weaknesses of epidemiology that he will describe.
He joined the Clinical Genetics Branch in October 2009 to study intensively why HPV is such a powerful carcinogenic exposure, akin to an acquired genetic trait with high penetrance for a cancer phenotype. The main studies in which Dr. Schiffman played a major role in the past 5 years, listed chronologically, include: The Portland Kaiser Cohort; the T...
Source: Videocast - All Events - May 2, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
CANCELLED - Getting to an Effective HIV Vaccine: Perspectives on Progress
DUE TO THE LIKELIHOOD OF INCLEMENT WEATHER IMPACTING THE DC METRO AREA AND THE NORTHEAST COAST, THIS LECTURE HAS BEEN POSTPONED.
James C. Hill Memorial Lecture
Virologist and vaccine expert Dr. Lawrence Corey will deliver the 2017 James C. Hill Memorial Lecture. His talk, titled “ Getting to an Effective HIV Vaccine: Perspectives on Progress, ” will review the state of HIV vaccine development and describe current strategies to advance the field.
Since 1999, Corey has served as principal investigator of the NIAID-supported HIV Vaccine Trials Network (HVTN), which is dedicated to accelerating development of a safe and ef...
Source: Videocast - All Events - March 13, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Getting to an Effective HIV Vaccine: Perspectives on Progress
James C. Hill Memorial Lecture
Virologist and vaccine expert Dr. Lawrence Corey will deliver the 2017 James C. Hill Memorial Lecture. His talk, titled “ Getting to an Effective HIV Vaccine: Perspectives on Progress, ” will review the state of HIV vaccine development and describe current strategies to advance the field.
Since 1999, Corey has served as principal investigator of the NIAID-supported HIV Vaccine Trials Network (HVTN), which is dedicated to accelerating development of a safe and effective preventive HIV vaccine. The HVTN has built an international scientific collaboration of investigators in 12 countries on ...
Source: Videocast - All Events - February 27, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Is the Right Flavor of Inflammation the Key to Successful Cancer Therapy?
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Romina Goldszmid received her Ph.D. working on dendritic cell-based vaccines for melanoma immunotherapy from the University of Buenos Aires, Argentina, part of which was performed as a visiting scholar in the laboratory of Dr. Ralph Steinman at the Rockefeller University. She then did her postdoctoral training in infectious diseases immunology with Dr. Alan Sher in the Laboratory of Parasitic Diseases (LPD) at NIAID. There, Dr. Goldszmid focused on the interplay between dendritic cells and natural killer cells during the early response to Toxoplasma gondii infecti...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Transforming Pancreatic Cancer into an Immunological Disease
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Jaffee currently serves as Deputy Director for the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins University (JHU), and Co-Director of the Immunology Program and Associate Director for Translational Sciences for SKCCC. She established the Cell and Gene Therapy Processing Facility (cGMP facility) at JHU. In 2007, she was appointed Deputy Director for the Institute for Translational and Clinical Research at JHU School of Medicine. She has also served as Chair of the Clinical Research Committee at SKCCC.
Dr. Jaffee has served on a number of commit...
Source: Videocast - All Events - October 3, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Oral HPV Continuum: Epidemiology of Oral HPV Infection, Persistence and HPV-related Oropharyngeal Squamous Cell Carcinoma
NIDCR Clinical Research Fellowship Grand Rounds
Oral HPV infection now causes the majority of oropharyngeal (tonsillar) cancers in the U.S. The incidence of HPV-related oropharyngeal cancer is increasing significantly, with men disproportionately affected. This talk reviews what is known about oral HPV infection, its natural history, and the epidemiology of HPV-related oropharyngeal cancers.
Gypsyamber D ’ Souza is an associate professor in epidemiology at the Johns Hopkins Bloomberg School of Public Health, with a joint appointment in the departments of International Health and Otolaryngology-Head and Neck Surgery at th...
Source: Videocast - All Events - September 14, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
