Engineered B Cells as an Approach to Cancer Therapy
Engineered T cells are the dominant form of cell therapy for cancer at the present time, an approach that has achieved considerable success, and remains actively under further development. T cells can attack cancer cells directly, given the right tools to recognize those cells and overcome the various immunosuppressive mechanisms deployed by cancerous tissue. There are other approaches to rousing the immune system to action, however, such as focusing on B cells. B cells carry out a variety of roles that are important in the coordination of the immune response, in providing targets for other cells to attack, and rousing tho...
Source: Fight Aging! - October 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living a...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is it Possible to Safely Tip the Balance in Cancer Treatment Towards Cell Death Rather than Cell Senescence?
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an important contribution to degenerative aging.
The straightforward approach to this issue would be to treat cancer patients with senolytic therapies to clear senescent cells after the anti-cancer treatment is complete...
Source: Fight Aging! - September 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Protection versus Harm: Cellular Senescence in the Context of Cancer
A little cellular senescence is a good thing. When a cell enters the state of senescence in response to potentially cancerous mutational damage it shuts down replication and secretes signals that attract the immune system. Immune cells destroy any such senescent, damaged, potentially dangerous cells that fail to destroy themselves. When senescent cells accumulate with age, however, as the immune system falters in its task of clearance, the inflammatory secretions of these errant cells - the senescence-associated secretory phenotype (SASP) - make the environment much more favorable for the creation and growth of cancer.
...
Source: Fight Aging! - September 9, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflam...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Worse Functional Decline with Age is Observed in Cancer Survivors
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories. (Source: Fight Aging!)
Source: Fight Aging! - August 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
TRIM28 Inhibits Alternative Lengthening of Telomeres
Telomeres are caps of repeated DNA sequences at the ends of chromosomes. A little of the telomere length is lost with each cell division. A somatic cell with short telomeres ceases replication, and usually self-destructs. All cancers must thus continually lengthen telomeres in order to engage in unfettered replication and growth. This makes interference in telomere lengthening an attractive strategy as the basis for a truly universal cancer therapy. A few research and development programs have this in mind, most of which are focused on the role of telomerase in telomere lengthening. There are alternative lengthening of tel...
Source: Fight Aging! - August 9, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent T Cells in the Context of Cancer
Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is beneficial in the short term, an important part of the panoply of mechanisms devoted to, separately, cancer suppression and regeneration. When senescent cells begin to linger, however, their secretions become highly disruptive to normal tissue function. Senescent cell accumulatio...
Source: Fight Aging! - August 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
YAP Upregulation as a Potentially Broad Basis for Cancer Therapies
The future of cancer therapy, and ultimately an end to cancer, will be built atop mechanisms that are as close to universal as possible, such as inhibition of telomere lengthening, or that are relevant to a large fraction of cancers, such as the example noted here. Only broadly applicable mechanisms allow for the cost-effective development of therapies, treatments that can be proven in a few forms of cancers and then immediately deployed to treat many other forms of cancer. Biochemically, cancers are highly variable, even within the same type, and the cancer subtype by cancer subtype approach to medical development has bee...
Source: Fight Aging! - July 23, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Localized Prostate Cancer Therapy: Interview with Shyam Natarajan, CEO of Avenda Health
Avenda Health, a medtech company based in Santa Monica, California has developed the Focal Therapy System. It provides AI-powered prostate cancer therapy with the aim of treating only tumorous tissues, while reducing side-effects compared with conventional therapies. The system recently received FDA breakthrough designation.
At present, there are limited treatment options for men with prostate cancer, with surgery and radiation therapy being the most commonly used approaches. However, these techniques pose significant risks for patients, including urinary and sexual dysfunction. The Avenda Focal Therapy System uses A...
Source: Medgadget - June 7, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Informatics Oncology Urology Source Type: blogs
Trojan Horse Virus Makes Tumors Destroy Themselves
Researchers at the University of Zurich have developed a virus-based therapy that causes a tumor to destroy itself. They modified an adenovirus, which is a common virus that typically infects the respiratory tract and which is already widely used in medicine, to deliver genetic material that codes for an anti-cancer protein. In a sneaky move, the researchers designed the therapy so that the virus would infect tumor cells, forcing them to destroy themselves.
Cancer therapies are constantly evolving. Immunotherapies, which include antibodies that stimulate the immune system to destroy cancer cells, are the latest class of...
Source: Medgadget - May 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Oncology Source Type: blogs
Positron Emission Tomography (PET) in Cardiology
Positron emission tomography (PET) imaging is useful in assessment of myocardial perfusion and viability, atherosclerotic plaque activity as well as cardiac innervation in heart failure. PET is also useful in prosthetic valve endocarditis, endocarditis associated with cardiac implantable electronic devices (CIED), infiltrative cardiomyopathy, aortic stenosis and cardio oncology [1].
PET imaging has superior diagnostic accuracy compared to SPECT (Single Photon Emission Computed Tomography). It has improved spatial and temporal resolution and can measure regional blood flow and has less radiation. In PET, high energy gamma...
Source: Cardiophile MD - April 20, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Positron emission tomography Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
