Cardio-Oncology is now the official journal of the International Cardio-Oncology Society (ICOS)
The worldwide role of ICOS
The International Cardio-Oncology Society was founded in 2009 after scientists demonstrated that cardiac side effects in patients being treated for cancer could be prevented. Years of subsequent research have demonstrated that cooperation between cardiologists and oncologists can meaningfully improve the outcomes of patients as well as their quality of life. Through promotion of training and study in cardio-oncology, ICOS has developed best practice strategies to prevent and treat cardiac toxicity in patients undergoing chemotherapy.
“It’s not just a matter of building up a society but s...
Source: BioMed Central Blog - September 26, 2018 Category: General Medicine Authors: Brett Harrison Tags: Open Access Publishing Cardio-Oncology Source Type: blogs
Methuselah Fund Closes Initial Fundraising, Reports on Some Early Investments
I'm pleased to note that the Methuselah Fund has closed its first fundraising effort after hitting the target amount, obtaining the support of many long-standing members of our community. The fund is a mixed for-profit/non-profit vehicle that is intended to expand the investment efforts undertaken by the Methuselah Foundation in past years, helping promising lines of rejuvenation research to make the leap from laboratory to commercial development. At the present point in time there are few enough rejuvenation focused companies that doing this well requires extensive connections within the research community, and a willingn...
Source: Fight Aging! - September 18, 2018 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
10 things a pediatric oncologist wants you to know
1. Cancer is not rare. Technically, childhood cancer is rare compared to adult cancer, but it’s not as rare as you think. Outside of my work, I can think of 3 people who I know personally that had a childhood cancer. A teammate on my high school basketball team, my sister-in-law, and a high school debate teammate. My guess is that you also know someone from church, a coworker’s kid, or one of your kids’ classmates who has been affected by this disease.
2. Curing cancer and preventing cancer is not the same thing. We do have a cure for the majority of childhood cancers. Nearly 90 percent of children dia...
Source: Kevin, M.D. - Medical Weblog - September 17, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/wendy-a-rhoades" rel="tag" > Wendy A. Rhoades, MD < /a > Tags: Conditions Oncology/Hematology Pediatrics Source Type: blogs
Focused Ultrasound and Intranasal Drug Delivery for Brain Cancer Therapy
Researchers at Washington University in St. Louis have developed a new method to bypass the blood-brain barrier and deliver drugs to the brain, which could be particularly useful in difficult-to-treat brain tumors. The technique involves administering drugs through an intranasal spray, meaning that the drug can travel directly into the brain along the trigeminal and olfactory nerves. Then, the researchers can use focused ultrasound to allow the drug to penetrate and accumulate in deeper layers of the tissue, and exert therapeutic benefit at the ultrasound-targeted region.
Drug therapy for brain tumors is challenging, beca...
Source: Medgadget - September 10, 2018 Category: Medical Devices Authors: Conn Hastings Tags: ENT Neurology Neurosurgery Oncology Source Type: blogs
Fight Aging! Newsletter, July 30th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
OncoSenX is the Oisin Biotechnologies Spinoff Targeting Cancer
Oisin Biotechnologies developers a programmable suicide gene therapy platform, initially used to clear senescent cells from old tissues and thereby produce rejuvenation. Since this approach can also be directed to kill cancerous cells, and with little alteration to the original details of senescent cell targeting, a spinoff company OncoSenX was formed to undertake that line of development. This class of therapy should be broadly applicable to many types of cancer, with little customization required: it currently targets a common mechanism that appears near universally across cancer types.
OncoSenX is a late stage ...
Source: Fight Aging! - July 26, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Turbulent French Press Bioreactor Makes Platelets from Stem Cells
Researchers at Kyoto University have developed a technique to produce platelets from induced pluripotent stem cells (IPS cells). Platelets are formed when small fragments break off from large cells called megakaryocytes within blood flow. The technique involves creating IPS megakaryocytes and then culturing them in a specialized bioreactor. The bioreactor mimics the turbulence of normal blood flow using a French press design to encourage the megakaryocytes to form platelets on a clinically useful scale. The technique can produce enough platelets for transfusions and could help to avoid platelet shortages.
Platelet transfus...
Source: Medgadget - July 25, 2018 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Pathology Source Type: blogs
Fight Aging! Newsletter, July 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Unity Biotechnology Starts First Human Trial of a Senolytic Therapy
The honor of running the first trial of a senolytic drug, albeit inadvertently, goes to one of the groups testing dasatinib or navitoclax back when those pharmaceuticals were first evaluated for cancer therapies. At that time nobody knew that these drugs could selectively destroy senescent cells, and were thereby far more valuable as a starting point for rejuvenation therapies than as cancer treatments. The first intentional human trial was started last year by Betterhumans, a non-profit organization. Now Unity Biotechnology has recently announced that their first human trial is underway, testing the ability of their initi...
Source: Fight Aging! - June 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics.
Exercise versus the Hallmarks of Aging
https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/
The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I di...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Uncovering Genes that Might be Sabotaged to Block Metastasis
Cancer research will accelerate meaningfully towards the goal of control of all cancer only when a majority of researchers are working on mechanisms common to large number of different cancer types. There are too many subtypes of cancer and too few scientists to make real progress when tackling cancers one by one. Shutting down metastasis is one grail of cancer research, as the majority of cancer deaths are caused when cancer spreads throughout the body, not by the initial tumor. Thus a search for common mechanisms of metastasis is one of the few presently viable approaches to the production of broader cancer therapies. Re...
Source: Fight Aging! - June 21, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Misdiagnosis: Obamacare Tried to Fix the Wrong Things and Prescribed the Wrong Treatments
By CHARLES SILVER and DAVID A.HYMAN
Today THCB is happy to publish a piece reflecting the learnings from Charles Silver and David Hyman’s forthcoming book Overcharged: Why Americans Pay Too Much For Health Care, shortly to be published by the libertarian leaning Cato Institute. In subsequent weeks we’ll feature commentary from the right (Michael Cannon) and from the left (Andy Slavitt) about the book and its proposals. For now please give your views in the comments–Matthew Holt
There are many reasons why the United States is “the most expensive place in the world to get sick.” In Part 1 of Overcharg...
Source: The Health Care Blog - June 19, 2018 Category: Consumer Health News Authors: matthew holt Tags: Economics OP-ED Cato Institute Charles Silver David A. Hyman Obamacare Overcharged Source Type: blogs
Fight Aging! Newsletter, May 28th 2018
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years.
The researchers analysed six factors that could impact on...
Source: Fight Aging! - May 27, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
PLASMAT Combines Cold Atmospheric Plasma with Electro or Photoporation to Kill Cancer Cells
Purdue University is reporting on a new method of targeting cancer cells, developed by scientists in its Nuclear Engineering department. Dubbed PLASMAT, the technique combines cold atmospheric plasma, an ionized gas that brings with it active oxygen or nitrogen species, and either laser-based or electric-based way of opening the membranes of cells.
The combined beam, which is near room temperature, effectively shoots killer molecules into the targeted cells and kills only the cells in its path. Nearby cells remain completely unharmed, and ones on the periphery of the beam tend to recover in lab studies.
The hardware...
Source: Medgadget - May 22, 2018 Category: Medical Devices Authors: Editors Tags: Surgery Source Type: blogs
Uncovering the Senolytic Mechanism of Piperlongumine
Senolytic compounds are those capable of selectively destroying senescent cells. They are useful because the buildup of senescent cells over time is one of the root causes of aging. A number of mechanisms have been discovered by which senescent cells can be provoked into self-destruction, such as bcl-2 inhibition or interference in FOXO4-p53 interactions. These examples are fairly well understood. Other mechanisms are known but less well understood; they require more work in order to proceed on the production of improved senolytic compounds.
In some cases, however, the primary mechanism of action of a compound found...
Source: Fight Aging! - May 21, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
