10 things a pediatric oncologist wants you to know

1. Cancer is not rare.  Technically, childhood cancer is rare compared to adult cancer, but it’s not as rare as you think.   Outside of my work, I can think of 3 people who I know personally that had a childhood cancer.  A teammate on my high school basketball team, my sister-in-law, and a high school debate teammate.   My guess is that you also know someone from church, a coworker’s kid, or one of your kids’ classmates who has been affected by this disease. 2. Curing cancer and preventing cancer is not the same thing.  We do have a cure for the majority of childhood cancers.  Nearly 90 percent of children diagnosed with cancer will survive. We are not done.  The treatments stink.  We can do better.  10 percent still die from cancer or from the effects of their treatment.  This is why we advocate.  We advocate for better and more effective cures.  We will not rest until we have it perfect. 3. I know my drugs have side effects.  Trust me.  I know.  See above. 4. With the above #2 statement in mind, put sunscreen on yourself and your children.  Teach them about the dangers of tobacco and lifestyles of excess (i.e., food, alcohol, stress).  Take care of yourself and teach them how to take care of themselves. These are preventative measures. 5. Vaccines save lives.  Some of my patients lose the immunity that they once had from their vaccines.   Until they are stro...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Pediatrics Source Type: blogs

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Publication date: Available online 23 May 2019Source: Journal of Cancer PolicyAuthor(s): Steve Langton, Derek Lowe, Simon N Rogers, Annette Plüddemann, Clare BankheadAbstractBackgroundThe ‘two-week rule’ (TWR) fast-track cancer referral system for head and neck cancers was introduced by the UK government in 2000, to facilitate earlier diagnosis. However, little work has compared stage on diagnosis of cancer before and after the implementation of the system.Objectives•Describe the presentation of oral cancer in Merseyside from 1992-2012.•To evaluate whether stage on presentation has improved after...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
ConclusionsThe investigative team developed a novel breast cancer treatment DA that is acceptable to women ≥70 years with a history of ER+, HER2-, early stage breast cancer. Next, the DA's efficacy needs to be tested with diverse older women newly diagnosed with breast cancer.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Upma Sharma, Pallavi Singhal, Kapil Bandil, Rajeshwar Patle, Anoop kumar, Kausar Neyaz, Surojit Bose, Ajay Kumar Dewan, Ravi Mehrotra, Veena Sharma, Mausumi BharadwajAbstractBackground: Despite being most preventable malignancies associated with smoked and smokeless tobacco products, squamous cell carcinoma of oral cavity is one of the most common malignancy in India. The aim of the present study was to evaluate the role of TLRs in oral pre-cancerous, cancerous cases and their genotypic correlation with HPV/EBV, co-infection &lifestyle habits...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: Cancer CellAuthor(s): Ruidong Xue, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng LiSummaryWe performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Black men with nonmetastatic prostate cancer did not appear more likely to die from this disease than white men when given similar access to care and standardized treatment, an analysis found.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 24 May 2019Source: Materials Chemistry and PhysicsAuthor(s): Gururaj M. Neelgund, Makobi C. Okolie, Folami K. Williams, Aderemi OkiAbstractA novel NIR (near infrared) active photothermal agent, CNTs-PAMAM-Ag2S has been synthesized by covalent grafting of polyamidoamine (PAMAM) to carbon nanotubes (CNTs) and subsequent deposition of Ag2S nanocrystallites. The potential of CNTs-PAMAM-Ag2S as a NIR active photothermal agent was preliminarily accessed by its electronic absorption spectrum measured in UV–vis–NIR region. The CNTs-PAMAM-Ag2S exhibited excellent photothermal effect an...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Materials Research and TechnologyAuthor(s): An Huang, Honglian Dai, Xiaopei Wu, Zheng Zhao, Yanzeng WuAbstractThe mesoporous hydroxyapatite (HAP) powder was synthesized by using the microemulsion (hexadecyltrimethyl ammonium bromide (CTAB)/cyclohexane/n-octyl alcohol) system. The optimal ratios of concentrations of CTAB, cyclohexane and n-octyl alcohol in the microemulsion on morphology of the HAP were studied. The effects of pHs and calcination temperatures on the phase composition of the HAP powder were discussed. The phase composition, morphology, mesoporo...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 23 May 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Giovanni Blandino, Fabio Valenti, Andrea Sacconi, Silvia Di AgostinoAbstractDeregulated cell metabolism is one of the cancer hallmarks. Mitochondrial DNA mutations and enzyme defects, aberrant tumor suppressor or oncogenic activities cause mitochondrial dysfunction leading to deregulated cellular energetics. The tumor suppressor protein, p53 is a tetrameric transcription factor that in response to diverse genotoxic and non-genotoxic insults activates a plethora of target genes to preserve genome integrity. In the las...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
Publication date: Available online 23 May 2019Source: CellAuthor(s): Ninib Baryawno, Dariusz Przybylski, Monika S. Kowalczyk, Youmna Kfoury, Nicolas Severe, Karin Gustafsson, Konstantinos D. Kokkaliaris, Francois Mercier, Marcin Tabaka, Matan Hofree, Danielle Dionne, Ani Papazian, Dongjun Lee, Orr Ashenberg, Ayshwarya Subramanian, Eeshit Dhaval Vaishnav, Orit Rozenblatt-Rosen, Aviv Regev, David T. ScaddenSummaryStroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have defined individual populations in th...
Source: Cell - Category: Cytology Source Type: research
ConclusionWe generated a second-generation CAR targeting either Lewis Y or GRP-78 with a truncated CD34-tag for purification. Because the differentiation and phenotype of the CAR-T product may have a critical impact on the post-infusion antitumor effect and persistence of the cells, we also investigated the phenotype of CAR-T product with different γc cytokines, i.e. IL-2, IL-7 and IL-15, to generate early differentiation stage cells with less exhaustion phenotypes. In the optimized protocol, by using the retroviral transduction system, starting from 3 × 107 PBMC, we're now able to produce approximately 109...
Source: Cytotherapy - Category: Cytology Source Type: research
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