An Investigation of How Telomerase Cancers can Switch to Become ALT Cancers
The paper I'll point out today is a timely one, given that the SENS Research Foundation's fundraiser for early stage work on a therapy for alternative lengthening of telomeres (ALT) cancers is nearing its close. There are still thousands of dollars left in the matching fund, so give it some thought if you haven't yet donated. The search for ways to safely sabotage ALT is a useful, important line of research because (1) blocking telomere lengthening is a path to a universal cancer therapy, (2) those research groups presently working on it are all looking to achieve this goal by interfering in the activities of telomerase, (...
Source: Fight Aging! - September 3, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 22nd 2016
This study provides additional fuel to really bolster research efforts by us and others in geroscience, a field that seeks to understand relationships between the biology of aging and age-related diseases. Aging is the most important risk factor for common chronic conditions such as heart disease, Alzheimer's and cancer, which are likely to share pathways with aging and therefore interventions designed to slow biological aging processes may also delay the onset of disease and disability, thus expanding years of healthy and independent lives for our seniors."
Longer-Lived Parents and Cardiovascular Outcomes
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Source: Fight Aging! - August 21, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A New $15,000 Challenge Grant Announced for SENS Cancer Research Crowdfunding
Earlier today at the Rejuvenation Biotechnology 2016 conference, the SENS Research Foundation folk announced a $15,000 challenge grant for the present OncoSENS cancer research crowdfunding effort. All donations from here forward will be matched dollar for dollar from the grant, and the deadline for the fundraiser has been extended for another thirty days to give this a chance to run. The funds raised from the community through this initiative will be used to carry out the first high-throughput screening of drug candidates for cancers that use the alternative lengthening of telomeres (ALT) mechanism to maintain their growth...
Source: Fight Aging! - August 17, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, August 15th 2016
In conclusion, our results demonstrate that circulating GDF11 levels are reduced in our mouse model of premature aging, which shares most of the symptoms that occur in normal aging. However, GDF11 protein administration is not sufficient to extend longevity in these progeroid mice. Although accelerated-aging mouse models can serve as powerful tools to test and develop anti-aging therapies common to both physiological and pathological aging, the existence of certain differences between the two processes implies that further investigation is still required to determine whether long-term GDF11 administration has a pro-surviva...
Source: Fight Aging! - August 14, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Crowdfunding a Universal Cancer Treatment: Only a Few Days Left in the Fundraiser
This year's SENS rejuvenation research crowdfunding event puts the spotlight on the SENS Research Foundation's cancer program. So far more than 300 people have donated, and more than $26,000 has been raised; with ten days left to go, it won't take that much more of an effort to reach the same number of donors and the same level of support given to last year's fundraiser, and which led to the success in that research program. As for all of the SENS research initiatives in the science of aging, the SENS Research Foundation's work on cancer aims to support a big, bold goal in medicine: to build a single type of therapy that c...
Source: Fight Aging! - August 8, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
