Fight Aging! Newsletter, August 22nd 2016

This study provides additional fuel to really bolster research efforts by us and others in geroscience, a field that seeks to understand relationships between the biology of aging and age-related diseases. Aging is the most important risk factor for common chronic conditions such as heart disease, Alzheimer's and cancer, which are likely to share pathways with aging and therefore interventions designed to slow biological aging processes may also delay the onset of disease and disability, thus expanding years of healthy and independent lives for our seniors." Longer-Lived Parents and Cardiovascular Outcomes Cardiovascular risk assessment currently identifies higher risk individuals through parental histories of early onset myocardial infarction. However, having relatively long-lived parents is associated with markedly lower coronary heart disease (CHD) risks and longer survival. Parental longevity associations with other common cardiovascular outcomes are little studied. We estimated associations between parents' age at death and common incident conditions plus mortality in a large middle-aged cohort. A New 15,000 Challenge Grant Announced for SENS Cancer Research Crowdfunding https://www.fightaging.org/archives/2016/08/a-new-15000-challenge-grant-announced-for-sens-cancer-research-crowdfunding/ Earlier today at the Rejuvenation Biotechnology 2016 conference, the SENS Research Foundation folk announced a 15,000 challenge grant for the present ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Purpose of review Established social gradients across a wide range of child health issues including obesity, anxiety, infectious diseases, injuries, prematurity and low birth weight suggest that much illness is avoidable and there is an imperative to intervene in this whole of society issue. This review examines recent advances in understanding of the pathways to health and health inequalities and their application to interventions to improve health equity. Recent findings Children's health develops over the life course in ways that are profoundly influenced by their entire developmental ecosystem including indi...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: POPULATION HEALTH: Edited by Kara Odom Walker Source Type: research
Purpose of review Liquid biopsies have emerged as a noninvasive alternative to tissue biopsy with potential applications during all stages of pediatric oncology care. The purpose of this review is to provide a survey of pediatric cell-free DNA (cfDNA) studies, illustrate their potential applications in pediatric oncology, and to discuss technological challenges and approaches to overcome these hurdles. Recent findings Recent literature has demonstrated liquid biopsies’ ability to inform treatment selection at diagnosis, monitor clonal evolution during treatment, sensitively detect minimum residual disease ...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: HEMATOLOGY AND ONCOLOGY: Edited by Brigitte Widemann Source Type: research
Purpose of review The issue of fertility preservation has become increasingly relevant as survival rates of children with cancer exceeds 80% at 5 years. Fertility preservation options are being utilized alongside less gonadotoxic therapeutic regimens in the treatment of these patients. The purpose of this review is to summarize the recent advances in fertility preservation in the pediatric, adolescent, and young adult population. Recent findings Education research involves both patient and provider; to increase understanding on both sides for improved adoption of techniques and higher rates of posttreatment fe...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: HEMATOLOGY AND ONCOLOGY: Edited by Brigitte Widemann Source Type: research
Purpose of review The prognosis of pediatric patients with metastatic solid tumors remains poor, necessitating development of novel therapeutic strategies. The biology of the pediatric tumor microenvironment (TME) presents obstacles for the efficacy of current therapeutic approaches including immunotherapies. Targeting various aspects of the TME in pediatric patients with solid tumors represents a therapeutic opportunity that may improve outcomes. Here we will discuss recent advances in characterization of the TME, and clinical advances in targeting the immune, vascular, and stromal aspects of the TME. Recent findin...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: HEMATOLOGY AND ONCOLOGY: Edited by Brigitte Widemann Source Type: research
Purpose of review To summarize the currently available definitive therapies for patients with inborn errors of immunity (IEIs) with a strong focus on recent advances in allogeneic hematopoietic cell transplantation (HCT) and gene therapy, including the use of alternative donors, graft manipulation techniques, less toxic approaches for pretransplant conditioning and gene transfer using autologous hematopoietic stem cells. Recent findings In the absence of a matched sibling or a matched related donor, therapeutic alternatives for patients with IEIs include alternative donor transplantation or autologous gene thera...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: HEMATOLOGY AND ONCOLOGY: Edited by Brigitte Widemann Source Type: research
DESPITE ongoing research, academics are struggling to turn the tide on the dementia crisis. One activity done for an excessively long period of time could be both increasing your risk and be an early symptom of the degenerative brain condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion It is suggested that waist circumference is the main factor for control over the time in strategies focused on BP management in adult population.
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophisiology Source Type: research
This study aimed to assess the dynamic thiol/disulphide balance in individuals with white-coat hypertension (WCH). Methods This cross-sectional study included a total of 117 individuals who presented to our outpatient cardiology clinic. Seventy patients were diagnosed with WCH. All blood samples were obtained from the patients after a minimum of 8 h of fasting, centrifuged immediately, stored in Eppendorf tubes, and protected at −80°C. Results The two groups were well-balanced in terms of age, gender, and BMI. Native thiol and total thiol levels were lower in the WCH group than in normotensiv...
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophisiology Source Type: research
Conclusion Our results indicate that people with declining mobility are significantly more likely to develop hypertension. Hence, improving mobility could be protective against hypertension for elderly individuals.
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophisiology Source Type: research
Conclusion Unmet need of hypertension care is substantially high, thus underpinning the need for intervention with a multifaceted approach
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophisiology Source Type: research
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