Magnetic Tentacle Robots for Minimally Invasive Procedures
Researchers at the University of Leeds in the UK have developed a magnetic tentacle robot that is intended for use in minimally invasive medical procedures, such as the treatment of tumors in the lungs. The soft tentacles are made from silicone. They are unlikely to cause tissue damage, and contain a series of magnets that can be influenced by external magnetic robots. The researchers hope that the technology will pave the way for minimally invasive procedures for lung cancer patients. In tests so far, the soft tentacles, which are just 2 mm in diameter, could travel 37% further into the lungs than conventional equipment. ...
Source: Medgadget - August 22, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Oncology Surgery universityleeds Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Selective Disruption of Replication in Cancerous Cells by Targeting PCNA
The future of cancer therapy will involve the targeting of mechanisms found broadly in many or all different types of cancer, that cancer cells cannot dispense with as they evolve rapidly within a tumor, and which have little to no effect on non-cancerous cells. Targeting telomerase to prevent the lengthening of telomeres can check the first two of those boxes, leaving the question of how best to effectively restrict the treatment to tumor cells. Targeting alternative lengthening of telomeres can check the second and third boxes, but the mechanism only operates in a minority of cancers. The research community is engaged in...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes from the 2023 Age-Related Disease Therapeutics Summit
The former Longevity Therapeutics conference series was renamed to the Age-Related Disease Therapeutics Summit and held its fifth event recently in San Francisco. It was a smaller meeting than in past years, perhaps a result of the recent downturn in the global financial and investment environment. Few investors were present. Nonetheless, one can usually learn something interesting from the presenting biotech founders and executives. I took a few notes while I was there to present on progress at Repair Biotechnologies, and they follow in the order of the conference program.
Birget Schilling from the Buck Institute f...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Senolytic Treatments as a Strategy to Improve Immune Function in Late Life
Senescent cells accumulate in tissues throughout the body with age. Cells become senescent constantly throughout life, largely by reaching the Hayflick limit on replication, but a small number due to potentially cancerous mutations, or other forms of damage and stress. Senescent cells are rapidly removed by the immune system in youth, keeping their numbers low, but the balance between creation and destruction is disrupted with aging. There is greater stress, but perhaps more importantly the immune system becomes less efficient, less able to clear senescent cells in a timely fashion. Since senescent cells actively secrete p...
Source: Fight Aging! - June 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Intratumoral Bacteria as an Injectable Anti-Cancer Treatment
Scientists at the Japan Advanced Institute of Science and Technology in Ishikawa, Japan have developed an anti-cancer treatment that consists of bacteria that are naturally found inside some tumors. Isolating and then injecting these bacteria into existing tumors appears to provoke a strong immune response that can lead to tumor destruction, without the need for advanced techniques such as bacterial genetic engineering or complex drug delivery. The concept of using bacteria to target tumors is not new, but typically it is studied in the context of using the bacteria to deliver a drug or using genetically engineered bacteri...
Source: Medgadget - May 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology JAIST Source Type: blogs
I ’ m a medical oncologist. Here ’ s why AI isn ’ t going to cure cancer.
As a cancer physician, the amount of data I obtain on my patients is ever-increasing, along with options for cancer therapies. This is, as the saying goes, a good problem to have, but the amount of data management oncologists must do after hours (because there isn’t enough time in the clinic day) to keep up
Read more…
I’m a medical oncologist. Here’s why AI isn’t going to cure cancer. originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 4, 2023 Category: General Medicine Authors: Jennifer Lycette, MD Tags: Tech Health IT Source Type: blogs
Nanoparticles Get Lymphatic Vessels Pumping
Researchers at the Georgia Institute of Technology have developed a nanotechnological solution for lymphedema, a failure of the lymphatic system that results in uncomfortable and irreversible fluid retention. Previous research efforts have focused on trying to grow new lymphatic vessels, but these researchers have taken a different approach, and instead engineered a drug delivery technology that can directly target sluggish lymphatic vessels and kickstart their pumping action.
Near infrared video demonstrating enhanced lymphatic contractile activity in model delivered drug loaded nanoparticles.
To achieve this, the r...
Source: Medgadget - March 27, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine News Oncology Surgery Source Type: blogs
Imagene Profiles Cancer Biomarkers in Real Time
Cancer therapies have proliferated over the past few decades, improving outcomes for many patients. But this variety requires accurate diagnostics and appropriate decision making to choose the optimal course of therapy. The current gold standard of identifying which cancer mutation is present is new generation sequencing (NGS), which provides a comprehensive genetic report, but can take up to six weeks to complete, requires a significant tumor sample size, and can only be done in an advanced laboratory at a high cost.
Imagene, a company headquartered in Tel Aviv, Israel, has developed AI-based image analysis software...
Source: Medgadget - March 22, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Diagnostics Exclusive Oncology Pathology biomarkers cancer biomarkers molecular profiling Source Type: blogs
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senotherapeutics Will Reduce the Side-Effects of Cancer Radiotherapy
Treatment with radiation to kill cancerous cells results in an increased burden of senescent cells, both in and around the tumor. This is a fair trade-off; a senescent cancerous cell may be harmful in and of itself, but it is a good deal less harmful in the long run than an active cancer cell. Unfortunately senescent cells produce pro-growth, pro-inflammatory signaling that is disruptive of tissue function, raises the risk of suffering a range of age-related conditions, and increases the risk of both reoccurrence of the treated cancer and the development of later unrelated cancers.
Thus given the work taking place o...
Source: Fight Aging! - January 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A View of Cellular Senescence in Cancer
Cellular senescence is a double-edged sword in the matter of cancer. A cancer cell turned senescent, and thus entered a state of growth arrest, is not a cancer cell that continues to replicate. It secretes pro-growth, pro-inflammatory signals that draw the attention of the immune system. This can be beneficial, helping to defeat a cancer, particularly in the early stages. After a certain point, however, too much cellular senescence aids the cancer in further growth. While it seems clear that senolytic treatments to remove lingering senescent cells are wholly beneficial after a cancer is defeated, it isn't clear that the sa...
Source: Fight Aging! - January 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
