Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
FDA Clears Two New Radiotherapy Planning CTs from Siemens
Procedure planning is an important part of radiation therapy in order to achieve optimal tumor reduction without damaging too much healthy tissue. Two newly FDA-cleared radiation therapy planning CT scanners from Siemens Healthineers are coming to America. The SOMATOM go.Sim and SOMATOM go.Open Pro are part of the company’s SOMATOM.go platform, designed to achieve the best possible clinical results and to help quicken planning procedures.
Somatom go.Sim is a 64-slice scanner, while the SOMATOM go.Open Pro produces images faster and/or sharper, since it generates 128 imaging slices per gantry rotation. Both of the ...
Source: Medgadget - December 13, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Radiation Oncology Radiology Source Type: blogs
Cancer Survivors have Double the Risk of Suffering a Later Stroke
We present a contemporary analysis of risk of fatal stroke among more than 7.5 million cancer patients and report that stroke risk varies as a function of disease site, age, gender, marital status, and time after diagnosis. The risk of stroke among cancer patients is two times that of the general population and rises with longer follow-up time. The relative risk of fatal stroke, versus the general population, is highest in those with cancers of the brain and gastrointestinal tract. The plurality of strokes occurs in patients older than 40 years of age with cancers of the prostate, breast, and colorectum. Patients of any ag...
Source: Fight Aging! - December 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
AI Tool to Predict Checkpoint Therapy ’s Effectiveness
Researchers from Case Western Reserve University have developed a new computational tool to predict, based on CT imaging, whether lung cancer patients will benefit from immune-checkpoint inhibitor cancer therapy. This is an exciting development for patients suffering from lung cancer, and may one day help inform medical decisions.
Currently, there are no predictive biomarkers to point to whether non-small cell lung cancer (NSLC) patients will benefit from immune-checkpoint inhibitor therapy, a new form of cancer therapy that helps the body’s immune system fight cancer more effectively. Currently, only 1 out of 5 NSLC ...
Source: Medgadget - December 2, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Informatics Medicine Source Type: blogs
Suffering from “chemo brain”? There’s hope and many things you can do
Some of the most common symptoms experienced by cancer patients are memory problems, difficulties with multitasking, and reduced attention and concentration. Historically, cancer patients with these symptoms were often diagnosed with depression. Research over the past decade has revealed that many cancer patients experience such symptoms as a consequence of specific damage to the brain caused by either their tumor or their treatment.
While radiation to the brain has long been linked to causing cognitive difficulties, the effects of chemotherapy on brain structure and function have only recently been discovered. We now know...
Source: Harvard Health Blog - November 20, 2019 Category: Consumer Health News Authors: Jorg Dietrich, MD, PhD Tags: Brain and cognitive health Cancer Memory Radiation Source Type: blogs
Plugging Holes in Blood Vessels Caused by Nanoparticle Therapy
While targeting nanoparticles to attack cancer cells can be effective at reducing primary tumors, they tend to create tiny holes within blood vessel walls that let some cancer cells escape and metastasize elsewhere. This is a serious side effect that may limit the usefulness of many nanoparticle-based cancer therapies in the long run, so researchers at National University of Singapore have been studying this matter and how to address it.
The team identified that nanomaterial-induced endothelial leakiness is caused by a variety of nanoparticles, including those made from silica, gold, and titanium dioxide. Moreover, anim...
Source: Medgadget - August 29, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Nanomedicine Oncology Source Type: blogs
Gold Nanostars Help Design New Nanomedicines
Researchers from Northwestern University have developed a novel way to track how nanoparticles interact with cancer cells and whether they reach their tagets. The team’s work shows that if a nanoparticle targets cancer cells, it undergoes more rotational and translational movement compared to nanoparticles that cannot target cancer cells effectively. This exciting development can be used to screen different nanoparticle formulations based on size, charge, shape, and targeting molecule to see if they are effectively targeting cancer cells in vitro in order to develop new more effective nanomedicine cancer therapies.
...
Source: Medgadget - August 27, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Medicine Nanomedicine Source Type: blogs
Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Support for LIfT Biosciences to Develop the LIFT Approach to a Universal Cancer Therapy
It is good to see that more of the promising technical approaches to aspects of aging, originally put forward by people in the SENS rejuvenation research network some years ago, are now making solid progress towards commercial implementation. The LIFT, or GIFT, approach to cancer therapy involves the transplantation of suitably aggressive leukocyte or granulocyte immune cells from a donor. At the time it was first demonstrated to be highly effective in mice, more than a decade ago, the underlying mechanisms were not well explored, and that always makes it hard to obtain further support from scientific funding institutions....
Source: Fight Aging! - August 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Like CD47, CD24 Also Acts as a " Don't Eat Me " Signal and is Abused by Cancer Cells
Cancer cells abuse signals used elsewhere in normal mammalian biochemistry to prevent immune cells from destroying other cells, such as CD47. Interfering in these "don't eat me" signals has produced significant gains in the development of effective cancer therapies that can target multiple types of cancer. Here, researchers describe a newly discovered "don't eat me" signal, CD24, that should allow this class of cancer therapy to be expanded to target cancers that have proved resilient to existing implementations. This and related lines of work that lead to more general anti-cancer platforms are one of the reasons why young...
Source: Fight Aging! - August 14, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Computational Simulations to Guide Cancer Therapy
Researchers from Argonne National Laboratory and University of Chicago have developed a new supercomputer-based tool to model tumor progression and destruction by the immune system. Their work demonstrates that computational simulations of immune-tumor interactions can infer whether or not a given tumor can be destroyed with immunotherapy. This exciting development may one day curate personalized therapies for cancer based on a patient’s individual biology.
Cancer immunotherapies are able to significantly improve survival
in various cancer types, however, immunotherapies do not benefit all patients
equally: Only 10-2...
Source: Medgadget - July 31, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Informatics Oncology Source Type: blogs
Alternative cancer therapies and the promise of false hope
How do you respond when patients with a good prognosis want to delay chemotherapy to try an anticancer diet for a few months or visit an unregulated clinic for unproven therapies? I’m asking because of an alarming finding of ASCO’s 2018 National Cancer Opinion Survey: “Nearly 4 in 10 Americans believe cancer can be cured solely […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 22, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/wendy-s-harpham" rel="tag" > Wendy S. Harpham, MD < /a > < /span > Tags: Physician Oncology/Hematology Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vesse...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Shelterin via TRF1 to Degrade Telomeres in Cancer Cells
Cancer cells depend on lengthening their telomeres, usually via telomerase activity. Telomeres are the caps of repeated DNA sequences at the ends of chromosomes. A little length is lost with each cell division, and when short a cell either self-destructs or becomes senescent and ceases replication. Cancer cells can only replicate continually if telomeres are extended continually. Thus some research groups are looking into sabotage of telomerase or the alternative lengthening of telomeres (ALT) processes as the basis for a truly universal cancer therapy. Others, as here, are investigating ways to interfere in mechanisms tha...
Source: Fight Aging! - July 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 17th 2019
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activiti...
Source: Fight Aging! - June 16, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
