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Light-activated cancer drugs without toxic side effects: fresh insight
Future cancer drugs that are activated by light and don’t cause the toxic side-effects of current chemotherapy treatments are closer to becoming a reality, thanks to new research made possible by the Monash Warwick Alliance, an intercontinental collaboration between the University of Warwick (UK) and Monash University (Australia). (Source: World Pharma News)
Source: World Pharma News - February 13, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Zimbabwe:Tougher Tobacco Use Laws Critical in the Fight Against Cancer
[263Chat] The World commemorated World Cancer Day on the 4th of February as is the norm each year, the commemoration ran under the theme "We can, I can" and that theme alone makes a lot of sense because surely collectively We can reduce cancer related illness and subsequently cancer related deaths. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 13, 2018 Category: African Health Source Type: news

Medical News Today: Why do some breast cancers become treatment-resistant?
A significant number of estrogen receptor-positive breast cancers are resistant to regular therapies. Why is that, and how can this obstacle be addressed? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 13, 2018 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Response of High-Grade Gliomas to Checkpoint Inhibitors Response of High-Grade Gliomas to Checkpoint Inhibitors
How should MRI findings be used to assess response of high-grade gliomas to immunotherapy?Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 13, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Local Immunotherapy of Cancer: Innovative Approaches Local Immunotherapy of Cancer: Innovative Approaches
Review the latest early research on intratumoral and intranodal immunotherapies.Journal of the National Cancer Institute (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 13, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

France's Cellectis wins U.S patents for gene editing technology
PARIS (Reuters) - The United States has granted French cell therapy group Cellectis two patents to deploy a technology known as CRISPR in T cells, which play a key role in the immune response to cancer, the company said on Tuesday. (Source: Reuters: Health)
Source: Reuters: Health - February 13, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

PFASs, chemicals commonly found in environment, may interfere with body weight regulation
(Harvard T.H. Chan School of Public Health) Boston, MA - A class of chemicals used in many industrial and consumer products was linked with greater weight gain after dieting, particularly among women, according to a study led by Harvard T.H. Chan School of Public Health. The chemicals -- perfluoroalkyl substances (PFASs) -- have been linked with cancer, hormone disruption, immune dysfunction, high cholesterol, and obesity. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2018 Category: Cancer & Oncology Source Type: news

Screening for ovarian cancer not recommended
(JAMA Network) The US Preventive Services Task Force (USPSTF) recommends against screening for ovarian cancer in women without symptoms and who are not known to be at high risk (such as those who have certain hereditary cancer syndromes that increase the risk for ovarian cancer). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2018 Category: Cancer & Oncology Source Type: news

Cancer-killing virus acts by alerting immune system
(University of California - San Francisco) A new UC San Francisco study has shown that a cancer-killing ('oncolytic') virus currently in clinical trials may function as a cancer vaccine -- in addition to killing some cancer cells directly, the virus alerts the immune system to the presence of a tumor, triggering a powerful, widespread immune response that kills cancer cells far outside the virus-infected region. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2018 Category: Cancer & Oncology Source Type: news

Nivolumab immunotherapy safe, feasible during chemoradiation for adv. head and neck cancer
(American Society for Radiation Oncology) Analysis of a clinical trial, RTOG Foundation 3504, finds that nivolumab immunotherapy can be administered safely in conjunction with radiation therapy and chemotherapy for patients with newly diagnosed local-regionally advanced head and neck cancers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

Medical cannabis significantly safer for elderly with chronic pain than Opioids
(American Associates, Ben-Gurion University of the Negev) The new study, published in The European Journal of Internal Medicine, found cannabis therapy is safe and efficacious for elderly patients who are seeking to address cancer symptoms, Parkinson's disease, post-traumatic stress disorder, ulcerative colitis, Crohn's disease, multiple sclerosis, and other medical issues. After six months, more than 18 percent of patients surveyed had stopped using opioid analgesics or had reduced their dosage. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

Cabozantinib shows significant first-line activity for differentiated thyroid cancer
(American Society for Radiation Oncology) Results of a new phase II clinical trial indicate that cabozantinib offers an active therapy option for patients with differentiated thyroid cancer (DTC) that has progressed following surgery and treatment with radioactive iodine (RAI). Thirty-four of 35 patients in the trial experienced a reduction in tumor size following treatment with the targeted kinase inhibitor, and more than half experienced reductions in excess of 30 percent. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

Phase II trial shows activity of durvalumab in recurrent/metastatic head and neck cancer
(American Society for Radiation Oncology) Analysis of the phase II CONDOR trial indicates that the immune checkpoint inhibitor durvalumab is tolerable among heavily pre-treated patients with recurrent or metastatic head and neck cancer and has the potential to slow growth in tumors with low or negative expression of the PD-L1 protein. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

Light-activated cancer drugs without toxic side effects: Fresh insight
(University of Warwick) Future cancer drugs that are activated by light and don't cause the toxic side-effects of current chemotherapy treatments are closer to becoming a reality, thanks to new research made possible by the Monash Warwick Alliance, an intercontinental collaboration between the University of Warwick (UK) and Monash University (Australia). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

Lower-dose radiation effective, safe for HPV+ head & neck cancer after induction chemo
(American Society for Radiation Oncology) Results of the phase II OPTIMA clinical trial indicate that patients with head and neck cancers associated with the human papillomavirus (HPV), including those with advanced nodal disease, can receive substantially lower radiation doses safely and effectively if they respond to induction chemotherapy initially. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

Cabozantinib shows promise as first line treatment for differentiated thyroid cancer
(University of Pennsylvania School of Medicine) A kinase inhibitor called cabozantinib could be a viable therapy option for patients with metastatic, radioactive iodine-resistant thyroid cancer. In a trial initiated and led by the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania, tumors shrunk in 34 out of 35 patients who took the drug, and more than half of those patients saw the tumor size decrease by more than 30 percent. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2018 Category: International Medicine & Public Health Source Type: news

EHRs Not Sufficient to Ensure Success in Value - Based Care
EHRs do not necessarily capture information needed; interoperability is poor, analytics are incomplete (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 13, 2018 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

Injection prompts mouse immune system to destroy tumors
Scientists found agents that, when injected into a tumor, direct the mouse immune system to destroy tumors of the same type throughout their bodies. The approach might be applied to many forms of cancer. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - February 13, 2018 Category: Consumer Health News Source Type: news

Structural basis for the interaction between the cell polarity proteins Par3 and Par6
Polarity is a fundamental property of most cell types. The Par protein complex is a major driving force in generating asymmetrically localized protein networks and consists of atypical protein kinase C (aPKC), Par3, and Par6. Dysfunction of this complex causes developmental abnormalities and diseases such as cancer. We identified a PDZ domain–binding motif in Par6 that was essential for its interaction with Par3 in vitro and for Par3-mediated membrane localization of Par6 in cultured cells. In fly embryos, we observed that the PDZ domain–binding motif was functionally redundant with the PDZ domain in targeting ...
Source: Signal Transduction Knowledge Environment - February 13, 2018 Category: Science Authors: Renschler, F. A., Bruekner, S. R., Salomon, P. L., Mukherjee, A., Kullmann, L., Schütz-Stoffregen, M. C., Henzler, C., Pawson, T., Krahn, M. P., Wiesner, S. Tags: STKE Research Articles Source Type: news

Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A
Educated natural killer (NK) cells have inhibitory receptors specific for self major histocompatibility complex (MHC) class I molecules and kill cancer cells more efficiently than do NK cells that do not have such receptors (hyporesponsive NK cells). The mechanism behind this functional empowerment through education has so far not been fully described. In addition, distinctive phenotypic markers of educated NK cells at the single-cell level are lacking. We developed a refined version of the image mean square displacement (iMSD) method (called iMSD carpet analysis) and used it in combination with single-particle tracking to...
Source: Signal Transduction Knowledge Environment - February 13, 2018 Category: Science Authors: Staaf, E., Hedde, P. N., Bagawath Singh, S., Piguet, J., Gratton, E., Johansson, S. Tags: STKE Research Articles Source Type: news

Cancer-fighting nanorobots programmed to shrink tumors
Scientists at Arizona State University programmed bits of DNA to target tumor cells and cut off the blood flow to them inside the body. The nanorobots successfully and safely killed cancers in mice. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2018 Category: Consumer Health News Source Type: news

Doctors Learn How to Talk to Patients About Dying Doctors Learn How to Talk to Patients About Dying
Clinicians can be so focused on fixing problems and saving lives that they often avoid talking to patients about their prognosis.Kaiser Health News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Immune Modulation in the Spotlight at AAD 2018 Immune Modulation in the Spotlight at AAD 2018
Immunomodulators for inflammatory diseases and cancer will be among the hot topics at the upcoming American Academy of Dermatology meeting.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 12, 2018 Category: Consumer Health News Tags: Dermatology News Source Type: news

VC Firms Still Find Liquid Biopsy Sexy
DiaCarta’s recent series B round shows that the promise of liquid biopsy for cancer detection continues to be attractive to investors. The Richmond, CA-based company revealed it has completed a $45 million funding round, with the closing led by Fortune Fountain Capital and subscribed to by Good Health Capital. The series B financing will support DiaCarta’s core XNA technology platform for early cancer detection and help the company expand its diagnostic products for non-invasive early detection and monitoring of cancers. The company said the plan is to perform the clinical trials for noninvasive early cancer de...
Source: MDDI - February 12, 2018 Category: Medical Devices Authors: Omar Ford Tags: Medical Device Business IVD Source Type: news

Delcath closes $5m offering
Delcath Systems (NSDQ:DCTH) has closed a $5 million offering of 212,000 shares of common stock, warrants to buy 38,000,000 shares of common stock and warrants to buy an aggregate of 500,000 shares of common stock. The New York-based company priced the offering at 2¢ per unit. Each unit was composed of one share of common stock and one common stock purchase warrant to buy two shares, according to a document filed with the SEC. Get the full story at our sister site, Drug Delivery Business News. The post Delcath closes $5m offering appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - February 12, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Funding Roundup Oncology Pharmaceuticals Wall Street Beat Delcath Systems Inc. Source Type: news

Buster and Kristen Posey want to strike out childhood cancers
Buster Posey is one of the faces of Major League Baseball — a squeaky-clean image coupled with three World Series rings that's been used to pitch everything from cars to power drinks. But beyond the endorsement deals and on-field success, what gets the San Francisco Giants all-star revved up is an effort led by he and his wife, Kristen, to raise money t o fight childhood cancers. Some of that money goes to the University of California, San Francisco, a few blocks down Third Street from AT&T Park. In… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - February 12, 2018 Category: Health Management Authors: Ron Leuty Source Type: news

How One Top Hospital Is Using Virtual Reality
Mainstream use of virtual reality (VR) headsets began about two years ago. In that time, the devices, which transport the user into a different world, have been used for entertainment, teaching, and healthcare. VR is another tool that can be used to help reduce patients pain. Currently, opioids are the standard treatment for pain relief. However, according to data from the CDC, 91 Americans die every day from an opioid overdose, and prescription opioids are a known driving factor in these deaths Last week, Cedars-Sinai Medical Center, one of the earliest adopters of VR in a healthcare setting, gave an update on the im...
Source: MDDI - February 12, 2018 Category: Medical Devices Authors: Omar Ford Tags: Software Digital Health Source Type: news

Cancer history in relatives boosts breast cancer risk
Having a first-degree relative with a family history of breast cancer sharply...Read more on AuntMinnie.comRelated Reading: At high risk for breast cancer? Start screening early More women get breast screening after ACA bans copays Both screening, treatment cut breast cancer deaths What are the risks of risk-based breast cancer screening? Do older women benefit from continued mammo screening? (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 12, 2018 Category: Radiology Source Type: news

Ultrasound for Rectal Cancer Staging Tied to More Chemoradiation
But no significant improvement in overall survival compared with CT of the abdomen and pelvis only (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 12, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pathology, Radiology, Journal, Source Type: news

Criteria for Prostate Cancer Trials Disproportionately Exclude Blacks
Trials sponsored by academic investigators, cooperative groups more likely to use these criteria (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 12, 2018 Category: Cancer & Oncology Tags: Oncology, Pathology, Pharmacy, Urology, Journal, Source Type: news

Imaging system helps determine chemo efficacy against breast cancer
A new optical imaging system helps determine which breast cancer patients will best respond to chemotherapy, according to researchers at Columbia University. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 12, 2018 Category: Consumer Health News Source Type: news

Contracting an STI could be deadly this Valentine ’s Day
Dr Tina Joshi, a lecturer in molecular microbiology at Plymouth University, spoke of the threat of antibiotic resistance - expected to kill more people than cancer in the next 30 years - in terms of STIs. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2018 Category: Consumer Health News Source Type: news

Abraham Lincoln Was Our Tallest President Ever. This May Be Why
Abraham Lincoln, who would have celebrated his 209th birthday on Feb. 12, left behind an impressive legacy during his time in office — but many Americans still associate the 16th president, first and foremost, with his towering height. Standing 6’4″, Lincoln is, to this day, the tallest president ever, edging out Lyndon Johnson by a full inch. Height wasn’t Lincoln’s only distinguishing physical characteristic. While he was in office, a journalist described the president’s “long pendulous arms” and “hands of extraordinary dimensions…far exceeded in proportion by ...
Source: TIME: Health - February 12, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Abraham Lincoln healthytime onetime Source Type: news

Researchers develop novel immunotherapy to target colorectal cancer
A Yale-led research team has developed an antibody that blocks tumors in animal models of colorectal cancer. (Source: Yale Science and Health News)
Source: Yale Science and Health News - February 12, 2018 Category: Universities & Medical Training Source Type: news

Ky. Medicaid expansion improves breast cancer care
Early data from Medicaid expansion in Kentucky since the passage of the Affordable...Read more on AuntMinnie.comRelated Reading: More women get breast screening after ACA bans copays Tax reform bill overturns ACA's individual mandate Study: ACA led to more early-stage cancer diagnoses CMS: State healthcare spending growth on the rise (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 12, 2018 Category: Radiology Source Type: news

Medical News Today: Cancer: Targeting protein may stop tumors from spreading
Researchers have now taken a major step in the prevention of cancer metastasis by identifying and targeting a protein that helps tumors to spread. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 12, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

ImmunoMet Appoints Vincent J. O'Neill, M.D., B.Sc., M.R.C.P, as Chief Medical Officer, and Allan L. Shaw as Chief Financial Officer
HOUSTON, Feb. 12, 2018 -- (Healthcare Sales & Marketing Network) -- ImmunoMet Therapeutics, a private biotechnology company focused on utilizing cellular metabolism to develop novel anti-tumor and immuno-oncology therapies, today announced the appointment... Biopharmaceuticals, Oncology, Personnel ImmunoMet Therapeutics, immunotherapy, immunotherapies (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 12, 2018 Category: Pharmaceuticals Source Type: news

Lung cancer drug resistance explained by computer simulations
Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib - an anticancer drug used to treat types of lung cancer. (Source: University of Bristol news)
Source: University of Bristol news - February 12, 2018 Category: Universities & Medical Training Tags: Research; Faculty of Science, Faculty of Science, School of Chemistry; Press Release Source Type: news

Sickle Cell Disease: When to Transfuse Sickle Cell Disease: When to Transfuse
Know the appropriate indications for transfusion when transfusion is not indicated in patients with sickle cell disease.CDC Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

' Cinderella' Cancer Gets Trial With Fairy-tale Ending?'Cinderella' Cancer Gets Trial With Fairy-tale Ending?
Upper tract bladder cancer is a rare malignancy and as such is difficult to study in a phase 3 clinical trial. But a determined group of investigators pulled it off and appear to have changed practice.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Cintas Corp.'s Farmer family donates $10M to boost cancer care in Cincinnati
The Farmer Family Foundation, whose trustees include the CEO of Cintas Corp., revealed today it is donating $10 million to help the Cincinnati Cancer Center seek designation as a national hub for cancer research. “It’s imperative that we join this effort … to make both an immediate and long-term impact on the fight against cancer right here in our community,” said Scott Farmer, CEO of Mason-based Cintas (Nasdaq: CTAS) and a trustee of the Farmer Family Foundation. “Cancer touches all of… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - February 12, 2018 Category: American Health Authors: Barrett J. Brunsman Source Type: news

' Cinderella' Cancer Gets Trial With Fairy-tale Ending'Cinderella' Cancer Gets Trial With Fairy-tale Ending
Upper tract bladder cancer is a rare malignancy and as such is difficult to study in a phase 3 clinical trial. But a determined group of investigators pulled it off and appear to have changed practice.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Morning Break: Sketchy Coverage Denials; Presidential Valentine; UV Lamps for Flu
(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 12, 2018 Category: Hematology Source Type: news

A&E, RTT and cancer waits - January 2018: explore the maps
NHS waiting lists around England, updated for January 2018. (Source: HSJ)
Source: HSJ - February 12, 2018 Category: UK Health Source Type: news

Cancer Risk With Old Age Due to Immune System Decline? Cancer Risk With Old Age Due to Immune System Decline?
The increase in cancer incidence with age may be more closely related to age-related declines in the immune system than to the steady accumulation of genetic mutations, suggests a mathematical analysis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Pennsylvania needs more doctors for medical marijuana program
About 355 doctors in Pennsylvania have been approved to certify patients for the state's medical marijuana program, according to Trib Total Media. But more than 16,000 residents have registered for the program to treat 17 state-approved illnesses and ailments, like Crohn's disease, cancer and Parkinson's disease. About 3,300 have been certified to receive medical marijuana, according to the Trib. About 300 more doctors have registered to ta ke the four-hour training course for certification into… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - February 12, 2018 Category: American Health Authors: Stacey Federoff Source Type: news

Photos show the reality of battling breast cancer
Helen Sheil, 76, from Queensland, had both breasts removed after being diagnosed with the disease 20 years ago, however, the condition has returned and spread to the mother-of-two's bones. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2018 Category: Consumer Health News Source Type: news

DNA Robots Target Cancer
Researchers use DNA origami to generate tiny mechanical devices that deliver a drug that cuts off the blood supply to tumors in mice. (Source: The Scientist)
Source: The Scientist - February 12, 2018 Category: Science Tags: Daily News Source Type: news

Experts develop revolutionise skin cancer jab
British scientists have created a cancer vaccine that fights the most deadly type of skin cancer – and learned how to predict who it will work for. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2018 Category: Consumer Health News Source Type: news

Using injectable self-assembled nanomaterials for sustained delivery of drugs
Because they can be programmed to travel the body and selectively target cancer and other sites of disease, nanometer-scale vehicles called nanocarriers can deliver higher concentrations of drugs to bombard specific areas of the body while minimizing systemic side effects. Nanocarriers can also deliver drugs and diagnostic agents that are typically not soluble in water or blood as well as significantly decrease the effective dosage. (Source: World Pharma News)
Source: World Pharma News - February 12, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news