AdaptImmune partners to advance promising cancer immunotherapies
Adaptimmune has entered into a collaboration and license agreement with Alpine Immune Sciences to advance Adaptimmune's next-generation SPEAR T-Cell products under development to treat a variety of cancers. Under the terms of the deal, Seattle-based Alpine Immune Sciences (NASDAQ: ALPN) will receive a $2 million upfront payment from Adaptimmune (NASDAQ: ADAP), which is based in Philadelphia and Oxfordshire, England. Alpine could earn up to an additional $288 million in development and commercializati on… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 15, 2019 Category: American Health Authors: John George Source Type: news

Azathioprine: Friend or Foe? Azathioprine: Friend or Foe?
A recent study presents new evidence for the association of azathioprine with increased risk of cutaneous malignancy, especially when combined with sunlight.The British Journal of Dermatology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 15, 2019 Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news

Blood test could determine if a cancer is likely to spread - and how fast
The test, developed by researchers at the Royal Marsden in London, analyzes fragments of DNA that are shed by tumors into the blood. It accurately predicted spread in 47 patients. (Source: the Mail online | Health)
Source: the Mail online | Health - May 15, 2019 Category: Consumer Health News Source Type: news

Medical News Today: How whole-grain rye consumption can improve gut health
A new study looks to both humans and mice to understand how some whole grains can help maintain gut health and prevent diabetes and cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 15, 2019 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news

Recent Immunotherapy Treatments for Metastatic Breast Cancer Recent Immunotherapy Treatments for Metastatic Breast Cancer
Kate M. O'Rourke looks at recent immunotherapy treatments for metastatic breast cancer that are proving effective.Medscape Oncology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 15, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology Article Source Type: news

Bowel cancer: Major signs and symptoms you must not ignore
BOWEL cancer is one of the most common types of cancer in the UK, with around 40,000 new cases being diagnosed every year. These are the major symptoms of bowel cancer you can not ignore and which mean you need to speak to your doctor. (Source: Daily Express - Health)
Source: Daily Express - Health - May 15, 2019 Category: Consumer Health News Source Type: news

Are Onions and Garlic Healthy? Here ’s What Experts Say
Garlic and onions are staples for many home cooks. But do these plants actually add any health benefits to your dishes? Or are they purely for flavor? People who try to eat colorful fruits and vegetables in order to get a wide range of vitamins and minerals may think that pale foods like onions and garlic don’t offer many nutrients. But although they may not look like nutritional powerhouses, experts say they are. Onions of all colors (including white) are good sources of vitamin C, vitamin B6, potassium and folate, while garlic is rich in vitamin C, vitamin B6, thiamin, potassium, calcium, phosphorous, copper and ma...
Source: TIME: Health - May 15, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Diet/Nutrition Source Type: news

Majority Of Sunscreens Tested Would Flunk Proposed FDA Safety Tests, Report Says
(CNN) — Nearly two-thirds of all sunscreens evaluated by the Environmental Working Group would not pass safety tests proposed by the US Food and Drug Administration, the consumer advocacy group announced Wednesday. The group released its analysis as part of its 2019 Guide to Sunscreens, a yearly report on sunscreen safety that the nonprofit began in 2006. The group said it analyzed the ingredients and performance of more than 1,300 products with sun protection factor, or SPF; 750 of those are marketed as beach and sport sunscreens. The analysis involves only a fraction of the sunscreen products sold in the United Sta...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 15, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Sunscreen Source Type: news

Big Slick unveils three more celebrity attendees
Three more celebrities will attend Big Slick Celebrity Weekend's annual party to benefit Children's Mercy. Cobie Smolders, Haley Joel Osment and Jake Tapper will travel to Kansas City for the weekend festivities. This is Smolder's first year attending the 10th-annual fundraiser for the Cancer Center. The event, which started as a small celebrity poker tournament, has raised more than $8 million for Ch ildren's Mercy since its inception. Hometown hosts and local legends Paul Rudd, Jason Sudeikis,… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2019 Category: Biotechnology Authors: Lily Lieberman Source Type: news

IO Biotech Initiates Global Phase 2 Portion of Clinical Trial For T-win(R) Immunotherapy in Non-small Cell Lung Cancer
COPENHAGEN, Denmark, May 15, 2019 -- (Healthcare Sales & Marketing Network) -- IO Biotech, a clinical-stage biopharmaceutical company developing novel, immune modulating anti-cancer therapies based on its proprietary T-win® technology, announced the i... Biopharmaceuticals, Oncology IO Biotech, NSCLC, Immunotherapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 15, 2019 Category: Pharmaceuticals Source Type: news

Could there be racial bias in cancer treatment? UNC research looks for solutions
A new study out of UNC Health is looking at ways to address racial disparity in cancer treatment – finding accountability and reminders of implicit bias may be the solution. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2019 Category: Biotechnology Authors: Seth Thomas Gulledge Source Type: news

Lung cancer warning - do your eyes look like this? The hidden signs revealed
LUNG cancer symptoms include having a cough that won ’t go away, chest pain, and difficulty breathing. But you could also be at risk of a tumour if you develop a distinctive change in your eyes. Should you speak to a doctor? (Source: Daily Express - Health)
Source: Daily Express - Health - May 15, 2019 Category: Consumer Health News Source Type: news

UK Scientists Produce Comprehensive Summary of Genes Associated with Cancer in Humans, Making Precision Medicine ‘More Precise’
Expanded ‘Cancer Gene Census’ is expected to accelerate development of new therapeutics and biomarker-based personalized medicine diagnostic tests for disease; could be useful for anatomic pathologists Oncology is one of the fastest-developing fields in precision medicine and use of DNA-based diagnostics. Surgical pathologists are helping many cancer patients benefit from the use of a companion […] (Source: Dark Daily)
Source: Dark Daily - May 15, 2019 Category: Laboratory Medicine Authors: Jude Tags: Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing Management & Operations anatomic pathology Cambridge Network Cancer Gene Cen Source Type: news

UK Scientists Produce Comprehensive Summary of Genes Associated with Cancer in Humans Making Precision Medicine ‘More Precise’
Expanded ‘Cancer Gene Census’ is expected to accelerate development of new therapeutics and biomarker-based personalized medicine diagnostic tests for disease; could be useful for anatomic pathologists Oncology is one of the fastest-developing fields in precision medicine and use of DNA-based diagnostics. Surgical pathologists are helping many cancer patients benefit from the use of a companion […] (Source: Dark Daily)
Source: Dark Daily - May 15, 2019 Category: Laboratory Medicine Authors: Jude Tags: Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing Management & Operations anatomic pathology Cambridge Network Cancer Gene Cen Source Type: news

Medical News Today: Why don't whales develop cancer, and why should we care?
Whales have a minimal risk of developing cancer, despite factors that may lead us to think otherwise. Why is this, and how can this knowledge help us? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 15, 2019 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

National Lung Cancer Audit Annual Report 2018
This report represents the culmination of nearly two years of patient care and follow up, data collection, data analysis and interpretation. Its purpose is to understand the current quality of care and outcomes for patients with lung cancer, to celebrate good practice and to highlight variability, to ensure that all patients have access to the best care. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 15, 2019 Category: Consumer Health News Source Type: news

National Audit of Breast Cancer in Older Patients: 2019 Annual Report
This third annual report describes the process and outcomes of care for 147,162 patients, diagnosed with breast cancer between 1st January 2014 and 31st December 2017 in England and Wales. The patterns of care received by people aged 70+ years are compared with the care received by people diagnosed with breast cancer aged 50 –69 years. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 15, 2019 Category: Consumer Health News Source Type: news

Study: Can extended space travel increase an astronaut's risk of cancer?
(Natural News) Astronauts make a lot of sacrifices in their line of work. The longer they stay in space, the more severely their health suffers. Latest research warns that long-term stays in space could drastically weaken the immune systems of astronauts, making them much more vulnerable to the onset and effects of deadly diseases like... (Source: NaturalNews.com)
Source: NaturalNews.com - May 15, 2019 Category: Consumer Health News Source Type: news

Trans Women Have Raised Odds of Breast Cancer, But Risk Still Small: Study
WEDNESDAY, May 15, 2019 -- Transgender women on gender-confirming hormone therapy have increased odds of breast cancer, but the overall risk is low and not as high as it is for the general female population, a new study finds. Trans women are those... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 15, 2019 Category: General Medicine Source Type: news

Diagnosis: Scans Suggested the Boy Had Cancer. But No Doctor Could Prove It. Why?
After the pain in his knee spread to other parts of his body, his mother pressed the doctors to figure out what was going on. (Source: NYT Health)
Source: NYT Health - May 15, 2019 Category: Consumer Health News Authors: LISA SANDERS, M.D. Tags: Lyphoma of the bone Lymphocytes Source Type: news

Novartis gets approval to sell Kymriah in Japan for $306,000
A Japanese government panel approved on Wednesday a price of 33.5 million yen ($305,800) for Novartis' cancer treatment Kymriah, allowing the Swiss drugmaker to press ahead with a campaign to kick-start sluggish sales of the treatment. (Source: Reuters: Health)
Source: Reuters: Health - May 15, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

CNO to lead development of Northern Ireland cancer plan
The chief nursing officer for Northern Ireland is to head up a group charged with developing a new strategy intended to help the country meet its “cancer increase challenge”. (Source: Nursing Times)
Source: Nursing Times - May 15, 2019 Category: Nursing Source Type: news

The Impact of Gender on Oncologic Outcomes of Bladder Cancer The Impact of Gender on Oncologic Outcomes of Bladder Cancer
How do bladder cancer outcomes differ between males and females?Current Opinion in Urology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 15, 2019 Category: Allergy & Immunology Tags: Urology Journal Article Source Type: news

Obesity medicine association announces major updates to its adult obesity algorithm
(Obesity Medicine Association) The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

ASCO: Promising Start to Pediatric MATCH Trial
Approximately 25% of patients with tumor samples submitted to the Pediatric MATCH program have been matched to an investigational therapy at an interim analysis reported ahead of the ASCO Annual Meeting. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

ASCO: Can Changes in Diet Reduce Deaths From Breast Cancer?
Researchers looked at whether eating a low-fat diet helped improve survival in breast cancer, in a study presented ahead of the ASCO Annual Meeting. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

ASCO: Assessing Low-Dose Chemo in Older, Frail Patients With Gastroesophageal Cancer
Researchers assessed outcomes with different chemo regimen doses in elderly or frail patients with gastroesophageal cancer, in this study presented ahead of the ASCO Annual Meeting. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Blood test can measure effectiveness of treatments for aggressive skin cancers
(NYU Langone Health / NYU School of Medicine) Blood tests that track the amount of tumor DNA can -- after only one month of drug therapy -- detect how well treatment is working in patients with skin cancer, a new study finds. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Enhanced anticancer compound may allow precise activation and tracking of treatment
(The Wistar Institute) Wistar and University of South Florida researchers have advanced a novel compound that specifically targets the endoplasmic reticulum (ER) stress response that is frequently hyperactivated in cancer and promotes survival of cancer cells during stressful conditions. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 15, 2019 Category: Biology Source Type: news

Cancer Research UK: Less chemotherapy better for older patients with some advanced cancers
(Cancer Research UK) Less chemotherapy is as effective at controlling disease for elderly or frail patients with advanced cancer of the stomach or oesophagus (food pipe), and leads to fewer side effects such as diarrhoea and lethargy. These are the results of a Cancer Research UK funded study, presented prior to the ASCO conference today (Wednesday). (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 15, 2019 Category: International Medicine & Public Health Source Type: news

Is Time to First Distant Recurrence of Advanced Melanoma Linked to Survival?
Researchers looked at whether time to first distant recurrence of metastatic melanoma was linked to survival outcomes. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

A new way of diagnosing and treating disease -- without cutting skin
(University of British Columbia) University of British Columbia researchers have developed a specialized microscope that has the potential ability to both diagnose diseases that include skin cancer and perform incredibly precise surgery -- all without cutting skin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Toy transformers and real-life whales inspire biohybrid robot
(Dartmouth College) Researchers create a remote-controlled soft robot that can transform itself to conduct targeted drug delivery against cancer cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

New clinical pathway for cancer patients leads to better outcomes, lower health care costs
(Burness) A new clinical pathway for cancer patients at Christiana Care Health System's Helen F. Graham Cancer Center& Research Institute is improving their quality of life, providing better health outcomes and delivering lower heath care costs, according to a study published in the May 2019 issue of the Journal of Clinical Pathways. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

SHINE and IOCB Prague enter Lu-177 process license agreement
(Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague)) SHINE Medical Technologies, Inc. and IOCB Prague have entered into an intellectual property license agreement providing SHINE with a global, exclusive license to a novel method for separating rare earth elements. SHINE will use the innovation to produce lutetium-177 (Lu-177) for the treatment of cancer. The separation technique was developed by the team of Dr. Miloslav Pol á š ek, from IOCB Prague. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

What are the neurological side effects of CAR T-cell therapy?
(Brigham and Women's Hospital) A team at Brigham and Women's Hospital recently cataloged the neurological symptoms of patients who had received CAR T-cell therapy to better understand its neurotoxic side effects. While neurological symptoms were prevalent -- 77 percent of patients experienced at least one symptom -- they were also temporary. The findings are published in Brain. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Blood biopsy: New technique enables detailed genetic analysis of cancer cells
(University of Michigan) A new way to cleanly separate out cancer cells from a blood sample enables comprehensive genetic profiling of the cancer cells, which could help doctors target tumors and monitor treatments more effectively. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Researchers pinpoint why lymphoma patients may become resistant to specific therapy
(H. Lee Moffitt Cancer Center& Research Institute) Researchers from Moffitt Cancer Center and Dana-Farber Cancer Institute have discovered a mechanism of drug resistance to Venetoclax ® , also known as ABT-199, a BCL-2 targeting drug commonly used to treat chronic lymphocytic leukemia and acute myeloid leukemia. Their findings, published in the journal Cancer Cell, also suggest a possible co-treatment strategy to overcome this resistance. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Clinicians could prescribe fitness apps to help cancer survivor's exercise
(University of Surrey) Fitness apps could be prescribed by clinicians to help patients recovering from cancer increase their physical activity levels, new research in the Journal of Cancer Survivorship reports. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Yale study identifies how cancer drug inhibits DNA repair in cancer cells
(Yale University) According to researchers at Yale Cancer Center, a cancer drug thought to be of limited use possesses a superpower of sorts: It is able to stop certain cancer cells from repairing their DNA in order to survive. The study, published today in the journal Science Translational Medicine, suggests that combining this drug, cediranib, with other agents could potentially deliver a lethal blow in cancer that uses a specific pathway -- or process -- to create DNA repair cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Liquid biopsy could identify cancer patients at risk of metastatic disease
(The Royal Marsden NHS Foundation Trust) Analyzing fragments of DNA that are shed by tumors into the bloodstream, could indicate early on whether patients are at risk of their cancer spreading, according to new research presented today. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Jawless fish take a bite out of the blood-brain barrier
(University of Wisconsin-Madison) A jawless parasitic fish could help lead the way to more effective treatments for multiple brain ailments, including cancer, trauma and stroke. A team of biomedical engineers and clinician-scientists at the University of Wisconsin-Madison and the University of Texas at Austin borrowed molecules from the immune system of the parasitic sea lamprey to deliver anti-cancer drugs directly to brain tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

New strategy of reprogramming regulatory T cells may improve cancer therapies
(Massachusetts General Hospital) Therapies that harness the power of the immune system against cancer have made remarkable progress against certain tumors but still remain ineffective in most cancer patients. A new study from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases describes a method of reprogramming regulatory T cells that usually suppress immune responses into inflammatory cells that not only permit but also intensify an antitumor immune response. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Enzyme PHLPP2 could be a viable drug target for treating prostate cancer
(Cold Spring Harbor Laboratory) Researchers propose a new druggable target that can put a damper on the spread of prostate cancer. Containing the threat at its origin organ greatly increases the survival rates of patients who suffer from the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Researchers identify new therapeutic target for metastatic prostate cancer
(Rockefeller University Press) Researchers in New York have found that treating human prostate cancer cells with a drug that targets a protein called PHLPP2 may prevent the cancer cells from spreading to other organs in the body. The study, which will be published May 15 in the Journal of Cell Biology, reveals that inhibiting PHLPP2 lowered the levels of MYC, an oncogenic protein that causes many different types of cancer that cannot be targeted by conventional drug therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Intraperitoneal vs IV Chemotherapy in Ovarian Cancer: How Do They Compare?
A trial compared two intraperitoneal chemotherapy regimens and an intravenous regimen for newly diagnosed advanced ovarian carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Promising Results With Trastuzumab Deruxtecan in Early HER2+ Breast Cancer
Researchers tested a novel antibody-drug conjugate known as trastuzumab deruxtecan in an expansion cohort of a phase I study of patients with advanced HER2+ breast cancer previously treated with trastuzumab emtansine. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Bavencio (Avelumab), Inlyta (Axitinib) Combination Approved for Advanced Renal Cell Carcinoma by FDA
Approval marks the first anti-PD-L1 therapy combination for RCC. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Drew Boxler Source Type: news

Report Provides Latest Incidence and Survival Statistics for Melanoma
The American Cancer Society's Cancer Facts& Figures 2019 report summarized the rate of melanoma over the past 30 years, mortality, and incidence based on sex and ethnicity. (Source: CancerNetwork)
Source: CancerNetwork - May 15, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Big data helps identify better way to research breast cancer's spread
(Michigan State University) Michigan State University researchers are analyzing large volumes of data, often referred to as big data, to determine better research models to fight the spread of breast cancer and test potential drugs. Current models used in the lab frequently involve culturing cells on flat dishes, or cell lines, to model tumor growth in patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2019 Category: International Medicine & Public Health Source Type: news