Former Aveo exec resigns as ImmunoGen CFO after fraud verdict
The chief financial officer of Waltham-based ImmunoGen has stepped down after a jury found him liable for defrauding investors at his previous company. David Johnston was one of three former Aveo Pharmaceuticals (Nasdaq: AVEO) executives accused by the U.S. Securities and Exchange Commission of misleading investors about the Cambridge biotech's ultimately failed effort to secure FDA approval for a kidney cancer drug in 2012 and 2013. While Aveo a nd the other executives reached settlements, Johnston… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 26, 2018 Category: Pharmaceuticals Authors: Allison DeAngelis Source Type: news

Implants May Still Hinder FFDM with Tomosynthesis
(MedPage Today) -- Presence of breast implants tied to decreased recall rates and cancer detection rates (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 26, 2018 Category: Hematology Source Type: news

Pfizer nabs fourth oncology approval in two months
The FDA has approved Pfizer ’s new drug, Daurismo, for patients with acute myeloid leukemia. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - November 26, 2018 Category: Pharmaceuticals Source Type: news

Keeping patients home, treating the untreatable: Doctors make business case for proton therapy
Columbus doctors say a joint venture for proton beam therapy by Nationwide Children's Hospital and OSU's James Cancer Hospital will keep patients now being referred elsewhere in town and offer a new option for recurring tumors. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 26, 2018 Category: Biotechnology Authors: Carrie Ghose Source Type: news

Keeping patients home, treating the untreatable: Doctors make business case for proton therapy
Columbus doctors say a joint venture for proton beam therapy by Nationwide Children's Hospital and OSU's James Cancer Hospital will keep patients now being referred elsewhere in town and offer a new option for recurring tumors. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 26, 2018 Category: Pharmaceuticals Authors: Carrie Ghose Source Type: news

Keeping patients home, treating the untreatable: Doctors make business case for proton therapy
Columbus doctors say a joint venture for proton beam therapy by Nationwide Children's Hospital and OSU's James Cancer Hospital will keep patients now being referred elsewhere in town and offer a new option for recurring tumors. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 26, 2018 Category: Biotechnology Authors: Carrie Ghose Source Type: news

Keeping patients home, treating the untreatable: Doctors make business case for proton therapy
Columbus doctors say a joint venture for proton beam therapy by Nationwide Children's Hospital and OSU's James Cancer Hospital will keep patients now being referred elsewhere in town and offer a new option for recurring tumors. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 26, 2018 Category: Pharmaceuticals Authors: Carrie Ghose Source Type: news

MRI shows promise for lung cancer screening
CHICAGO - Nearly a decade ago, CT surpassed x-ray as the imaging modality of...Read more on AuntMinnie.comRelated Reading: CT lung cancer screening foiled by low adherence New decision aids may revamp CT lung cancer screening CT lung screening reduces cancer mortality in men by 26% Access to CT lung screening varies by population density More CT screening may be needed for high-risk smokers (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 26, 2018 Category: Radiology Source Type: news

Study Shows Cancer Patients Can Benefit from Opioid Switching
Switching from one prescription opioid to another often solves the problem of debilitating side effects or inadequate pain relief, according to a recent study involving a wide range of cancer patients. Opioids are not all the same. And neither are those they are helping. Despite the increasing government restrictions and the frenzy over potential abuse, opioids can be a lifesaver for a mesothelioma patient finding the right fit. “I’ve been through both sides of that switching issue,” said Tim Crisler, a 16-year pleural mesothelioma survivor told The Mesothelioma Center at Asbestos.com. “It worked gr...
Source: Asbestos and Mesothelioma News - November 26, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Many With Polyps Delay Follow-Up Colonoscopy
People whose colonoscopies find adenomas – polyps that can become cancer -- are routinely asked to come back for another colonoscopy in three years, but a surprisingly high percentage fail to get the follow-up, a new study reports. (Source: WebMD Health)
Source: WebMD Health - November 26, 2018 Category: Consumer Health News Source Type: news

Israeli Company Set To Begin Testing New Radiation Cancer Therapy
An Israeli medical technology company is set to begin testing a new radiation cancer therapy, that kills cancer cells while sparing surrounding tissue, in leading medical centers in Italy. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - November 26, 2018 Category: Pharmaceuticals Authors: Robin Seaton Jefferson, Contributor Source Type: news

The mediating effect of sleep disturbance on the relationship between non-malignant chronic pain and suicide death - Owen-Smith AA, Ahmedani BK, Peterson E, Simon GE, Rossom RC, Lynch F, Lu CY, Waitzfelder BE, Beck A, DeBar L, Sanon V, Maaz Y, Khan S, Miller-Matero LR, Prabhakar D, Frank C, Drake CL, Braciszewski J.
IMPORTANCE: Few studies have examined the relationship between non-malignant chronic pain (NMCP) and suicide death and even fewer have specifically explored what role sleep disturbance might play in the association between NMCP and suicide death. O... (Source: SafetyLit)
Source: SafetyLit - November 26, 2018 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Many Patients With Polyps Delay Follow - up Colonoscopy: Study
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 26, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Preventive Medicine, News, Source Type: news

Obesity Tied to Increased Risk for Early - Onset CRC in Women
Relative risk for early - onset colorectal CA nearly twice as high in obese women as those of normal weight (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 26, 2018 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Gynecology, Internal Medicine, Oncology, Journal, Source Type: news

ADT May Up Risk for Heart Failure in Prostate Cancer Patients
Heart failure risk higher for androgen deprivation therapy users in propensity score - matched analysis (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 26, 2018 Category: Cancer & Oncology Tags: Cardiology, Oncology, Pharmacy, Journal, Source Type: news

Lung Cancer Screening Implementation Guide Developed
Implementation guide designed to increase levels of lung cancer screening for heavy smokers (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 26, 2018 Category: Cancer & Oncology Tags: Family Medicine, Internal Medicine, Oncology, Pathology, Pulmonology, Radiology, Journal, Source Type: news

Youth Smoking Decline Mirrors Rise in Vaping Popularity
Large rise in youth vaping, decline in past 30 - day smoking prevalence accelerated around 2014 (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 26, 2018 Category: Cancer & Oncology Tags: Family Medicine, Nursing, Oncology, Pediatrics, Pulmonology, Journal, Source Type: news

The Promises (and Problems) of Real World Data
By David Kronfeld, Head of Real World Data Innovation, Medidata Solutions Medtech is just starting to access the rich well of real-world data (RWD), which offers some incredible opportunities to build more successful and useful devices. RWD technology can be employed to improve patient recruitment, efficiently deploy a sales team, identify unmet needs in regions, and to tell a value story. But there is a problem with medical device companies’ expectations of RWD. Data aren’t magic—they are a digital representation of what actually happens in a real care setting—and there is no such thing as complete...
Source: Mass Device - November 26, 2018 Category: Medical Devices Authors: MassDevice Tags: Sponsored Content Medidata Solutions Source Type: news

Medical News Today: 'DNA origami' tackles multidrug-resistant cancer cells
Scientists have developed a 'DNA nanoplatform' that carries anticancer drugs to targeted cancer cells and also prevents the cells from expelling the drug. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 26, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

New evidence shows chemotherapy, radiation cancer treatments may be linked to decline in cognitive performance
FINDINGSUCLA researchers conducted a study of breast cancer survivors to better understand if lower activity of telomerase (an enzyme that helps maintain the health of cells) along with DNA damage (a factor in cellular aging) were associated with worse cognitive performance, such as attention and motor skills. The study showed that lower telomerase activity and more DNA damage were associated with worse cognitive performance.BACKGROUNDCancer treatments may accelerate biological aging in cells.A previous UCLA study published in npj Breast Cancer in December 2017 linked lower telomerase activity and more DNA damage with expo...
Source: UCLA Newsroom: Health Sciences - November 26, 2018 Category: Universities & Medical Training Source Type: news

Chemotherapy, radiation cancer treatments may be linked to decline in cognitive performance
FINDINGSUCLA researchers conducted a study of breast cancer survivors to better understand if lower activity of telomerase (an enzyme that helps maintain the health of cells) along with DNA damage (a factor in cellular aging) were associated with worse cognitive performance, such as attention and motor skills. The study showed that lower telomerase activity and more DNA damage were associated with worse cognitive performance.BACKGROUNDCancer treatments may accelerate biological aging in cells.A previous UCLA study published in npj Breast Cancer in December 2017 linked lower telomerase activity and more DNA damage with expo...
Source: UCLA Newsroom: Health Sciences - November 26, 2018 Category: Universities & Medical Training Source Type: news

Medical News Today: What you need to know about breast cancer
Breast cancer survival rates are rising as screening and treatment improve. But breast cancer is still the most invasive cancer in women. Find out who might have a greater risk, what symptoms to look out for, and the treatment options a person might face. Plus, learn about the types of breast cancer and the stages. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 26, 2018 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Transplant patient develops cancer from donated kidney
Pauline Hunt, from Ayrshire, feels she is "fighting someone else's cancer" after receiving a "death sentence". (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 26, 2018 Category: Consumer Health News Source Type: news

Health Care Digest: Genentech's blood cancer win, a boost for Gilead's HIV PrEP and a tiny IPO swings at antibiotics
Editor's note: The San Francisco Business Times is launching this weekly health care digest by reporter Ron Leuty. It features  a roundup of local news items, musings from notable figures, insights from other publications and must-reads from our own newsroom. As always, we'd love to hear what you think and how we can improve. Please email biotech reporter Ron Leuty (rleuty@bizjournals.com) with any feedback, suggestions or possible news items for this feature. Venclexta — a cancer-fighting… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 26, 2018 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

Women 75 and Older Benefit from Annual Mammo
(MedPage Today) -- Significant number of invasive cancers found (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 26, 2018 Category: Hematology Source Type: news

Medical News Today: Ovarian cancer statistics
Knowing the statistics on ovarian cancer can help a person better understand the condition. However, it is important to remember that everyone has a different experience with cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 26, 2018 Category: Consumer Health News Tags: Ovarian Cancer Source Type: news

ORIC Pharmaceuticals Appoints Matt Panuwat as Chief Business Officer
SAN FRANCISCO, Nov. 26, 2018 -- (Healthcare Sales & Marketing Network) -- ORIC Pharmaceuticals, a clinical-stage oncology company focused on discovery and development of novel therapies against treatment-resistant cancers, today announced that Matt Panuwa... Biopharmaceuticals, Oncology, Personnel ORIC Pharmaceuticals, glucocorticoid receptor (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 26, 2018 Category: Pharmaceuticals Source Type: news

Karmanos Cancer Institute recognizes its 2018 Heroes of Cancer
(Source: Karmanos Cancer Institute)
Source: Karmanos Cancer Institute - November 26, 2018 Category: Cancer & Oncology Source Type: news

How to live longer - the one dinner food you should AVOID or risk bowel cancer
HOW to love longer: Avoid an early death by eating a healthy, balanced diet, and by doing regular exercise. You could lower your risk of deadly bowel cancer symptoms by avoiding this dinner, it ’s been claimed. (Source: Daily Express - Health)
Source: Daily Express - Health - November 26, 2018 Category: Consumer Health News Source Type: news

FOBT Colorectal Cancer Screening Only Effective in Men FOBT Colorectal Cancer Screening Only Effective in Men
Fecal occult blood tests to detect colorectal cancer led to survival benefits and treatment of reduced intensity in men, especially men with left-sided tumors, not in women, Finnish trial data indicate.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 26, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Many Patients With Polyps Delay Follow-up Colonoscopy: Study
MONDAY, Nov. 26, 2018 -- Many people found to have colon polyps (adenomas) that can lead to cancer don't have follow-up colonoscopies at recommended times, a new study finds. Patients who have certain types of adenomas, or large or numerous ones,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 26, 2018 Category: General Medicine Source Type: news

Lung Cancer Screening Implementation Guide Developed
MONDAY, Nov. 26, 2018 -- The American Lung Association and the American Thoracic Society have established a website to guide implementation of lung cancer screening, according to an editorial published in the Nov. 1 issue of the American Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 26, 2018 Category: Pharmaceuticals Source Type: news

Obesity Tied to Increased Risk for Early-Onset CRC in Women
MONDAY, Nov. 26, 2018 -- Obesity is associated with an increased risk for early-onset colorectal cancer (CRC) among women, according to a study recently published in JAMA Oncology. Po-Hong Liu, M.D., M.P.H., from Massachusetts General Hospital in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 26, 2018 Category: Pharmaceuticals Source Type: news

ADT May Up Risk for Heart Failure in Prostate Cancer Patients
MONDAY, Nov. 26, 2018 -- For patients with prostate cancer, androgen deprivation therapy is associated with an increased risk for heart failure, according to a study published online Nov. 7 in the Journal of Clinical Pharmacology. Hui-Han Kao, from... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 26, 2018 Category: Pharmaceuticals Source Type: news

Cancer survivor, 25, to have a pioneering operation to REVERSE her early menopause
Adele Stevens, from Reading, is said to be the 'second patient' to undergo ovarian cryopreservation to restore fertility, after chemotherapy for bone cancer gave her the menopause 20 years early. (Source: the Mail online | Health)
Source: the Mail online | Health - November 26, 2018 Category: Consumer Health News Source Type: news

Cancer warning - do your fingernails have these strange streaks? Signs of deadly cancer
CANCER symptoms vary depending on which part of the body is affected by a  tumour. You could be at risk of deadly tumour signs if your fingernails have these dark-coloured streaks. Symptoms of skin cancer revealed. (Source: Daily Express - Health)
Source: Daily Express - Health - November 26, 2018 Category: Consumer Health News Source Type: news

Dana-Farber's plan for Gillette facility worries small hospital nearby
Sturdy Hospital in Attleboro has objected to news that the state ’s biggest cancer hospital plans to open a potentially competing cancer program 12 miles away. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 26, 2018 Category: Biotechnology Authors: Jessica Bartlett Source Type: news

Medical News Today: Do cancer treatments accelerate brain aging?
A new study finds connections between key markers of biological aging and signs of cognitive decline years after the completion of breast cancer treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 26, 2018 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Sentinel Lymph Node Imaging in Urologic Oncology Sentinel Lymph Node Imaging in Urologic Oncology
What role might sentinel node imaging have in the detection of lymph node metastases in urological malignancies?Translational Andrology and Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2018 Category: Consumer Health News Tags: Urology Journal Article Source Type: news

High-Resolution Anoscopy for Anal Cancer Screening in HIV High-Resolution Anoscopy for Anal Cancer Screening in HIV
Is high-resolution anoscopy an effective and tolerable means of screening HIV patients at high risk of anal cancer?HIV Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2018 Category: Consumer Health News Tags: HIV/AIDS Journal Article Source Type: news

Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma
Molecularly targeted therapy and immunotherapy are changing the treatment landscape of soft tissue sarcoma.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Researchers find more recently diagnosed cancer survivors likely to drink, smoke
(Virginia Tech) Recently diagnosed cancer survivors are more likely to drink alcohol, use tobacco, and frequent tanning beds than people in later stages of recovery, according to a research team from the Virginia Tech Carilion Research Institute and Roswell Park Comprehensive Cancer Center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 26, 2018 Category: Cancer & Oncology Source Type: news

Study identifies a genetic driver of deadly prostate cancer
(Cedars-Sinai Medical Center) A new study has identified a novel molecular driver of lethal prostate cancer, along with a molecule that could be used to attack it. The findings were made in laboratory mice. If confirmed in humans, they could lead to more effective ways to control certain aggressive types of prostate cancer, the second-leading cause of cancer death for men in the US. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 26, 2018 Category: Cancer & Oncology Source Type: news

Fred Hutch at ASH: Press briefing on CAR T-cell therapy, CRISPR for blood disorders, more
(Fred Hutchinson Cancer Research Center) Fred Hutchinson Cancer Research Center's latest findings on cancer immunotherapies, CRISPR for blood disorders, stem cell transplantation and insights on the immune system and cancer will be featured at the 60th annual meeting of the American Society of Hematology, which will be held Dec. 1-4 in San Diego. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 26, 2018 Category: Cancer & Oncology Source Type: news

Cancer researchers ID 'Achilles heel' of drug-resistant tumors
(University of California - San Francisco) UC San Francisco scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies. In the process, they devised a new two-pronged approach that yields an effective treatment for these cancers in the laboratory and holds tremendous promise for the future of precision medicine, they said. The findings are detailed in a study published Nov. 26 in the journal Nature Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 26, 2018 Category: Cancer & Oncology Source Type: news

Mutations boost immunity: Toward a cancer vaccine
(Arizona State University) In a new study, Stephen Albert Johnston and his colleagues describe a method for pinpointing tumor-specific factors in blood that can elicit a protective immune response in the body and may one day be harnessed to produce an effective vaccine against the disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 26, 2018 Category: Biology Source Type: news

Targeting MC1R in metastatic melanoma
(University of Colorado Anschutz Medical Campus) University of Colorado Cancer Center study describes a molecule that seeks out melanoma cells, for imaging and potentially for therapy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 26, 2018 Category: Biology Source Type: news

CAR T studies highlight Abramson Cancer Center research at ASH Annual Meeting
(University of Pennsylvania School of Medicine) Penn researchers will present findings at the 60th American Society of Hematology Annual Meeting and Exposition in San Diego, including studies that evaluate CAR T combinations, how the timing of CAR T therapy may impact its effectiveness, and which patients who currently aren't eligible for CAR T therapy should have greater access. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 26, 2018 Category: International Medicine & Public Health Source Type: news

Intermittent fasting: No advantage over conventional weight loss diets
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Intermittent fasting helps lose weight and promotes health. However, it is not superior to conventional calorie restriction diets, scientists from the German Cancer Research Center (DKFZ) and Heidelberg University Hospital have found out in a study called HELENA -- the largest investigation on intermittent fasting to date. The scientists conclude that there are many paths leading to a healthier weight. Everybody must find a diet plan that fits them best and then just do it! (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 26, 2018 Category: International Medicine & Public Health Source Type: news

Fine-tuning cell death: New component of death machinery revealed
(Walter and Eliza Hall Institute) An important component of the microscopic machinery that drives cell death has been identified by Australian scientists.Studying the 'pro-death' machinery that forces damaged, diseased or unwanted cells to die, the research team revealed a protein called VDAC2 was critical for the function of a key pro-death protein called Bax. The team also showed VDAC2 contributed to the killing of certain cancer cells by anti-cancer agents. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 26, 2018 Category: International Medicine & Public Health Source Type: news