British Journal of Cancer press notice
(Cancer Research UK) These are upcoming paper publications of interest for journalists. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

New cell lines produce NIST monoclonal antibody for improved biologic drugs
(National Institute of Standards and Technology (NIST)) NISTmAb, the world's first standardized monoclonal antibody has become a valuable tool for biomanufacturers developing new biologic therapies for cancers, autoimmune disorders and infectious diseases. Although the molecule has been precisely characterized, the current proprietary method for its production has not.In a new paper, NIST researchers describe how they have taken the first step to solve this dilemma: engineering three mouse cell lines to produce nonproprietary versions of NISTmAb that closely resemble the characteristics of the original reference material. ...
Source: EurekAlert! - Medicine and Health - July 31, 2018 Category: International Medicine & Public Health Source Type: news

Therapy for Rare Cancers receives FDA approval following trials at Penn's Abramson Cancer
(University of Pennsylvania School of Medicine) The US Food and Drug Administration (FDA) has approved the first ever non-surgical treatment for the rare neuroendocrine cancers pheochromocytoma and paraganglioma. The approval was based on a multi-center trial led by researchers in the Abramson Cancer Center of the University of Pennsylvania and was granted to Progenics Pharmaceuticals for AZEDRA (iobenguane I131). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

Women and infants introduces new way to guide breast surgeries
(Care New England) Women& Infants Hospital of Rhode Island, a Care New England hospital, is introducing a new way for physicians to mark and find breast lesions. LOCalizer ™ is an FDA-cleared system that uses the latest technology to bring more precision for providers and less stress for patients. Women& Infants is the first in the region to adapt this new technology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

Acidic pH: The weakness of cancer cells
(Institute for Research in Biomedicine (IRB Barcelona)) A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

Alliance for Cancer Gene Therapy (ACGT) takes on solid tumor cancers
(Alliance for Cancer Gene Therapy) ACGT provides $1.5 million in cancer gene therapy grants to tackle solid tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

Turning off protein could boost immunotherapy effectiveness on cancer tumors
(Johns Hopkins Medicine) Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy in the Johns Hopkins Kimmel Cancer Center discovered inhibiting a previously known protein could reduce tumor burdens and enhance the effectiveness (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

Research into cell-to-cell signalling mechanism may lead to new cancer treatments
(University of Exeter) Pioneering new research into the way in which cells communicate with each other could hold the key to unlocking new, improved treatment for life-threatening diseases, including cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 31, 2018 Category: International Medicine & Public Health Source Type: news

How doctors could save £200million a year if they stop prescribing expensive drugs
NHS Improvement believes that some of the biggest savings in the UK could be made if doctors stopped prescribing the breast cancer wonder drug Herceptin. (Source: the Mail online | Health)
Source: the Mail online | Health - July 31, 2018 Category: Consumer Health News Source Type: news

Mayo Clinic Q and A: Uterine polyps rarely are cancerous
DEAR MAYO CLINIC: I have a few small uterine polyps that my health care provider says are not likely to be cancerous and that I could be reevaluated in six months to see if further testing is needed. Is it common for uterine polyps to turn into cancer? I am 49. ANSWER: It is rare [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 31, 2018 Category: Databases & Libraries Source Type: news

In the Loop: Breast cancer survivors head to Italy for International Dragon Boat Festival
A Jacksonville-based dragon boat racing team made up of breast cancer survivors does most of its paddling locally, but a recent event gave the Mammoglams a reason to take their skills overseas. Five years ago, Laura Brown dipped a toe ? or paddle, as it were ? into?dragon boat racing?and fell in love. "It?s a [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 31, 2018 Category: Databases & Libraries Source Type: news

To Boost Colon Cancer Screening, Use the Mail
(Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - July 31, 2018 Category: Cancer & Oncology Source Type: news

CDK12-mediated transcriptional regulation of noncanonical NF-{kappa}B components is essential for signaling
Members of the family of nuclear factor B (NF-B) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-B complexes are retained in the cytoplasm by the inhibitory protein IBα, whereas noncanonical NF-B complexes are retained by p100. Although activation of canonical NF-B signaling through the IBα kinase complex is well studied, few regulators of the NF-B–inducing kinase (NIK)–dependent processing of noncanonical p100 to p52 and the subsequent nuclear translocation of p52 have ...
Source: Signal Transduction Knowledge Environment - July 31, 2018 Category: Science Authors: Henry, K. L., Kellner, D., Bajrami, B., Anderson, J. E., Beyna, M., Bhisetti, G., Cameron, T., Capacci, A. G., Bertolotti-Ciarlet, A., Feng, J., Gao, B., Hopkins, B., Jenkins, T., Li, K., May-Dracka, T., Murugan, P., Wei, R., Zeng, W., Allaire, N., Buckle Tags: STKE Research Articles Source Type: news

Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling
The ability of cells to adapt their response to growth factors in relation to their environment is an essential aspect of tissue development and homeostasis. We found that signaling mediated by the Eph family of receptor tyrosine kinases from cell-cell contacts changed the cellular response to the growth factor EGF by modulating the vesicular trafficking of its receptor, EGFR. Eph receptor activation trapped EGFR in Rab5-positive early endosomes by inhibiting Akt-dependent vesicular recycling. By altering the spatial distribution of EGFR activity, EGF-promoted Akt signaling from the plasma membrane was suppressed, thereby ...
Source: Signal Transduction Knowledge Environment - July 31, 2018 Category: Science Authors: Stallaert, W., Brüggemann, Y., Sabet, O., Baak, L., Gattiglio, M., Bastiaens, P. I. H. Tags: STKE Research Articles Source Type: news

Brexit is bad for the NHS, say surveyed doctors
Nearly eight out of 10 doctors voted to remain Related items fromOnMedica ‘Governments must fund health systems to combat climate change’ May pledges UK will remain part of European medicines regulation NHS lagging on preventing cancer and heart deaths NHS planning for supply problems following Brexit Joined-up approach needed to recruit overseas doctors (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 31, 2018 Category: UK Health Source Type: news

FDA Approves Azedra for Rare Neuroendocrine Tumors FDA Approves Azedra for Rare Neuroendocrine Tumors
The radioactive systemic agent or radiopharmaceutical is administered by intravenous injection and is the first FDA-approved drug in this setting.FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - July 30, 2018 Category: Neurology Tags: Hematology-Oncology News Alert Source Type: news

Why life after cancer can be nearly as hard as the diagnosis itself
Laura Fulcher, from Warwick, was just 29-years-old when she was diagnosed with bowel cancer. Today, she still struggles with the physical and psychological damage it caused. (Source: the Mail online | Health)
Source: the Mail online | Health - July 30, 2018 Category: Consumer Health News Source Type: news

How Do We Predict Anti-PD-1 Therapy Response in Melanoma?
A set of reproducible biomarkers are associated with better response rates to anti –PD-1 therapy in patients with advanced melanoma. (Source: CancerNetwork)
Source: CancerNetwork - July 30, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

What Caused the Enlarged Lymph Node in This Otherwise Healthy Man ’s Neck?
An otherwise healthy 38-year-old man presents with an enlarged lymph node in the right side of the neck. Surgical resection of the lymph node is performed. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 30, 2018 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

Clinical Genome Workgroup Offers Guidance to Clinicians With Minimal Backgrounds in Genetics
Oncologists should refer patients who want traditional genetic counseling and/or have preexisting psychosocial factors that would increase risk of an adverse psychological outcome of counseling. (Source: CancerNetwork)
Source: CancerNetwork - July 30, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Can New Algorithm Shed Light on Treatment Resistance in Head and Neck Cancer?
The CoGAPS gene activity algorithm may elucidate molecular changes that occur as H&N tumors acquire resistance to cetuximab, says a Johns Hopkins team. (Source: CancerNetwork)
Source: CancerNetwork - July 30, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Would Routine Genomic Testing For Cancer And Heart Risk Make Economic Sense?
One Yale genetics expert argues that population-wide genomic screening would be worth it, even if only 1% of Americans were to learn they have genetic abnormalities that put them at high risk for deadly diseases. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - July 30, 2018 Category: Pharmaceuticals Authors: Arlene Weintraub, Contributor Source Type: news

Nitrate in drinking water increases the risk of colorectal cancer, according to study
(Natural News) Researchers from Aarhus University in Denmark have linked increased levels of nitrate found in drinking water to the risk of developing colon and rectal cancer. The results of the study, published in the International Journal of Cancer, also revealed that the risk factors for developing the conditions occur at concentrations far below the current drinking... (Source: NaturalNews.com)
Source: NaturalNews.com - July 30, 2018 Category: Consumer Health News Source Type: news

Cannabis drug may help pancreatic-cancer patients live almost THREE TIMES longer, study finds
Researchers from Queen Mary University of London found that diseased mice live longer when they are given the marijuana compound cannabidiol alongside a common chemotherapy drug. (Source: the Mail online | Health)
Source: the Mail online | Health - July 30, 2018 Category: Consumer Health News Source Type: news

Substance in cannabis 'could boost pancreatic cancer treatments'
Scientists say cannabidiol could extend patients ’ lives by a matter of yearsA substance found in cannabis plants might boost treatments for patients with pancreatic cancer, research in mice has suggested.Cannabidiol, or CBD, is not psychoactive, meaning it does not produce feelings of being high in those who take it. It is extracted from hemp plants and is legal in the UK, although a CBD product must be licensed before it can be advertised as having health benefits. At present, there are no licensed CBD-only medicines in the UK, but it is being used in a number of clinical trials,including for treating psychosis.Con...
Source: Guardian Unlimited Science - July 30, 2018 Category: Science Authors: Nicola Davis Tags: Cancer research Pancreas cancer Medical research Cannabis Drugs Society Science Health Source Type: news

SkinVision gets $7.6M to continue expanding skin cancer app
Amsterdam-based skin cancer screening app SkinVision has raised  $7.6 million in new funding from existing investors Leo Pharma and PHS Fund, with additional contributions from undisclosed new backers described by the company as " high net worth impact investors. " (Source: mobihealthnews)
Source: mobihealthnews - July 30, 2018 Category: Information Technology Source Type: news

DNA mutations 'hotspots' may help determine cancer risk, study says
Researchers identified mutation " hotspots " in DNA where genetic mutations are significantly raised, leading to potentially better cancer risk determination (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 30, 2018 Category: Consumer Health News Source Type: news

Medical News Today: What are the symptoms of late stage bladder cancer?
The symptoms of stage 4 bladder cancer include tiredness, weakness, and pain. Stage 4 is the most advanced stage of cancer. The standard treatment for late-stage cancer is chemotherapy, but treatment will often focus on palliative care. Learn more about the symptoms of stage 4 bladder cancer and the survival rate here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 30, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Numerous lawsuits claim link between baby powder and ovarian cancer, so is it safe or not?
While some suits already heard in the U.S. have resulted in compensation, studies on talcum powder's potential link to the gynecological cancer have produced often contrary conclusions. (Source: CBC | Health)
Source: CBC | Health - July 30, 2018 Category: Consumer Health News Tags: News/Health Source Type: news

Fertility Often Preserved in Female Childhood-Cancer Survivors Fertility Often Preserved in Female Childhood-Cancer Survivors
Most female childhood-cancer survivors (CCSs) show normal hormonal and ultrasound markers of ovarian reserve, according to Dutch researchers.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 30, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Prostate cancer symptoms: Three signs when you pee you must never ignore
PROSTATE cancer symptoms do not usually appear until the disease has progressed. While certain signs may not mean you definitely have cancer, they must never be ignored. Three symptoms are linked to when you go for a pee. (Source: Daily Express - Health)
Source: Daily Express - Health - July 30, 2018 Category: Consumer Health News Source Type: news

Sun ’ s Harms Rise After Organ Transplant
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 30, 2018 Category: Cancer & Oncology Tags: Dermatology, Oncology, Immunology, Organ Transplants, News, Source Type: news

Young Cancer Survivors Have High Risk of Endocrine Diseases
Results suggest the need for screening, surveillance in survivors (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 30, 2018 Category: Cancer & Oncology Tags: Endocrinology, Family Medicine, Internal Medicine, Oncology, Pediatrics, Journal, Source Type: news

Acupuncture May Cut Arthralgia From Aromatase Inhibitors
Clinical significance of the pain reduction remains uncertain (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 30, 2018 Category: Cancer & Oncology Tags: Oncology, Orthopedics, Pharmacy, Rheumatology, Anesthesiology & amp; Pain, Journal, Source Type: news

'We ’ll never be normal again:’ Little boy who’s been through a lot serves as honorary survivor at Relay for Life
A kindergartner from Wisconsin who was diagnosed with Wilms tumor serves as honorary survivor at Relay for Life.07/30/2018 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - July 30, 2018 Category: Urology & Nephrology Source Type: news

Free sunscreen offered at Santa Monica and Malibu beaches this summer
UCLA Health, sunscreen companyBrightGuard and the nonprofit organizationIMPACT Melanoma last week unveiled the first of dozens of new sun-safety stations that will dispense free sunscreen to the public at Los Angeles-area beaches.Robert Hernandez/UCLA HealthAlumnus Sinjin Smith and Dr. Jennifer HsiaoUCLA alumnus Sinjin Smith, whose legendary beach volleyball career spanned more than 25 years, joined the kickoff and spoke about the importance of sun protection.The campaign is an effort to help people have access to sunscreen and protect themselves against skin cancer, a condition that affects one in five Americans...
Source: UCLA Newsroom: Health Sciences - July 30, 2018 Category: Universities & Medical Training Source Type: news

MRI-Targeted Biopsies May Have a Role in Active Surveillance for Prostate Cancer MRI-Targeted Biopsies May Have a Role in Active Surveillance for Prostate Cancer
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 30, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Scientists find similar levels of carcinogens in traditional and e-cigarette users
Popular e-cigarettes are often marketed to help smokers quit and lower their cancer risks, but new research from the University of California, San Francisco found carcinogens in vapers. (Source: the Mail online | Health)
Source: the Mail online | Health - July 30, 2018 Category: Consumer Health News Source Type: news

mRCC: Impact of CABOSUN and CheckMate-214
Martin H. Voss, M.D., discusses the positive results of the CABOSUN trial.07/30/2018 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - July 30, 2018 Category: Urology & Nephrology Source Type: news

CarboFix wins FDA nod for its carbon/PEEK pedicle screws
CarboFix Orthopedics Ltd. has won FDA approval for a spinal screw system for use in people with advanced spinal cancer. The CarboClear carbon fiber pedicle screw system was designed to restore the integrity of the spinal column, even in the absence of fusion, for a limited time period in patients with advanced-stage thoracic and lumbar spine tumors. The screw system will hold the spine securely until patients are able to undergo spinal fusion, according to the Herzeliya, Israel-based company. The FDA gave the system 510(k) clearance. CarboClear pedicle screws are made of continuous carbon fibers reinforced polymer (PE...
Source: Mass Device - July 30, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Implants Oncology Surgical CarboFix Orthopedics FDA icotec AG Source Type: news

Radiation Therapy Can Increase Mesothelioma Survival Time
Too many patients with malignant pleural mesothelioma are going without adjuvant radiotherapy that could extend their lives significantly, according to Dr. Bin Teh at Houston Methodist Hospital in Texas. Teh is the senior author of a recent study — the largest of its kind — that examined the role and extent of radiation therapy in the overall treatment of mesothelioma. He and his colleagues found only 3.1 percent of patients diagnosed with pleural mesothelioma underwent radiotherapy treatment in combination with aggressive surgery. “Surgery plus radiation improves overall survival,” Teh, vice chair ...
Source: Asbestos and Mesothelioma News - July 30, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Should Every Metastatic Breast Cancer Patient Undergo NGS? Should Every Metastatic Breast Cancer Patient Undergo NGS?
Experts debate the advantages and disadvantages of next-generation genomic sequencing in patients with metastatic breast cancer.Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 30, 2018 Category: Consumer Health News Tags: Hematology-Oncology Article Source Type: news

"Please do not act violently towards the staff": expressions and causes of anger, violence, and aggression in Israeli cancer patients and their families from the perspective of oncologists - Granek L, Ben-David M, Bar-Sela G, Shapira S, Ariad S.
Expressions of anger within the healthcare context are a common occurrence, particularly in clinical situations where patients can experience emotional distress in the face of illness. The purpose of this study was to examine one aspect of this phenomenon ... (Source: SafetyLit)
Source: SafetyLit - July 30, 2018 Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news

Optimal Cancer Pain Management Means Understanding Pain Psychology Optimal Cancer Pain Management Means Understanding Pain Psychology
Pain psychology expert Dr Beth Darnall discusses the highly influential role psychology has in the experience of pain and how clinicians can treat pain better.Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 30, 2018 Category: Consumer Health News Tags: Hematology-Oncology Expert Interview Source Type: news

Medical News Today: How cells actively stop breast cancer from becoming invasive
Contrary to previously held beliefs, new research shows that the so-called myoepithelial cells are not just a passive barrier against breast cancer cells. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 30, 2018 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Q & A: Leprosy Increases as World Gives Attention to Newer Endemic Diseases
A young boy from the Philippines with leprosy. The chronic disease is curable, and if treated in time disabilities related to the disease can be averted. Courtesy: moyerphotos/CC By 2.0By Elisio MuchangaMAPUTO, Jul 30 2018 (IPS)In the first six months of this year, the southern African nation of Mozambique has already registered 300 more cases of leprosy, some 951 cases, than it registered for the whole of 2017.The country, which had previously eliminated the chronic disease in 2008, is receiving funding from the Nippon Foundation—a non-profit philanthropic organisation from Japan that is active in many countrie...
Source: IPS Inter Press Service - Health - July 30, 2018 Category: International Medicine & Public Health Authors: Elisio Muchanga Tags: Africa Development & Aid Featured Headlines Health Population Poverty & SDGs Regional Categories TerraViva United Nations Nippon Foundation Source Type: news

Counting the benefits from U of M's million-dollar mouse
A genetically engineered mouse has brought in $1 million in licensing fees to the University of Minnesota for its use in cancer research. The Minnesota Daily reports on the mouse and its unique advantages: Its plasma cells don't die and can be used as antibodies to help detect cancer cells. The U of M licensed the antibodies to Cell Signaling Technology of Danvers, Mass., which sells antibodies to researchers. The U collects 4 perc ent of revenue from Cell Signalling's sale of antibodies; the 15-year-old… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 30, 2018 Category: Pharmaceuticals Authors: Mark Reilly Source Type: news

New RCT Favors Standard of Care for Squamous Cervical Cancer New RCT Favors Standard of Care for Squamous Cervical Cancer
Neoadjuvant chemotherapy falls short of chemoradiation in this new study.Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 30, 2018 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Liver cancer symptoms: This colour change in your poo could be a sign of the cancer
LIVER cancer symptoms are triggered when cells start dividing uncontrollably in this organ. Causes of the cancer include excessive drinking, infection with hepatitis and possibly obesity. Watch out for these five signs of liver cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - July 30, 2018 Category: Consumer Health News Source Type: news

Nanobiotix inks $47m financing to support nanomedicine development
Nanobiotix (PAR:NANO.PA) inked a non-dilutive financial deal with the European Investment Bank last week to support the development of its nanoparticle-based cancer therapies. The Paris, France-based company said it landed a five-year loan to borrow up to €40 million ($46.7 million) contingent upon a set of performance milestones. Get the full story at our sister site, Drug Delivery Business News. The post Nanobiotix inks $47m financing to support nanomedicine development appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - July 30, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Funding Roundup Oncology Pharmaceuticals Wall Street Beat nanobiotix Source Type: news