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Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma
Immune checkpoint inhibitors targeting the programmed cell death 1 receptor (PD-1) improve survival in a subset of patients with clear cell renal cell carcinoma (ccRCC). To identify genomic alterations in ccRCC that correlate with response to anti–PD-1 monotherapy, we performed whole-exome sequencing of metastatic ccRCC from 35 patients. We found that clinical benefit was associated with loss-of-function mutations in the PBRM1 gene (P = 0.012), which encodes a subunit of the PBAF switch-sucrose nonfermentable (SWI/SNF) chromatin remodeling complex. We confirmed this finding in an independent validation cohort of 63 c...
Source: ScienceNOW - February 15, 2018 Category: Science Authors: Miao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bosse, D., Wankowicz, S. M., Cullen, D., Horak, C., Wind-Rotolo, M., Tracy, A., Giannakis, M., Hodi, F. S., Drake, C. G., Ball, M. W., Allaf, M. E., Snyder, A., Hellmann, Tags: Medicine, Diseases reports Source Type: news

Innate receptor sees cancer growth factor
(Source: ScienceNOW)
Source: ScienceNOW - February 15, 2018 Category: Science Authors: Scanlon, S. T. Tags: twil Source Type: news

Obesity May Give Men With Melanoma a Survival Advantage
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - February 15, 2018 Category: Cancer & Oncology Source Type: news

Highly Processed Foods Tied to Higher Cancer Risk
(Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - February 15, 2018 Category: Cancer & Oncology Source Type: news

Ovarian cancer actually begins in the fallopian tubes
Lead researcher Dr Ron Drapkin, an associate professor at University of Pennsylvania, says the recent findings will likely lead to advancements in prevention, detection and treatment of the disease (Source: the Mail online | Health)
Source: the Mail online | Health - February 14, 2018 Category: Consumer Health News Source Type: news

Florida woman is 12th person in world to have rare cancer
Rose Yarusskaya of Florida is in her third round of a battle against a rare head and neck cancer that keeps coming back due to an even rarer mutation that keeps her body from fighting tumors. (Source: the Mail online | Health)
Source: the Mail online | Health - February 14, 2018 Category: Consumer Health News Source Type: news

Ultra-processed foods linked to increased cancer risk
(Source: CNN.com - Health)
Source: CNN.com - Health - February 14, 2018 Category: Consumer Health News Source Type: news

Single Fathers Are More Likely to Die Early, Study Says
A large new study of parents in Canada found that single fathers have a higher premature mortality rate than single mothers or parents who are paired up. The study tracked more than 40,000 people for 11 years and found that single dads died soonest, and also had the least healthy lifestyles. The study, which was published in The Lancet Public Health, could not ascertain what made single dads die sooner, but after adjusting for age, lifestyle, health and socio-demographic characteristics, their risk of death over the course of the study was more than twice as high as other parents. The researchers found that single fathers...
Source: TIME: Health - February 14, 2018 Category: Consumer Health News Authors: Belinda Luscombe Tags: Uncategorized healthytime Parenting Source Type: news

This Is the Link Between Processed Foods and Cancer
Processed snacks, drinks and desserts may be associated with a higher risk of cancer, according to a new study. The research, published Wednesday in The BMJ, focused on ultra-processed foods, which tend to be high in fat, saturated fat, sugar and salt. (Past research has found that Americans get 61% of their calories from highly processed foods.) In the new study, researchers found that, among almost 150,000 French adults, a 10% increase in the proportion of ultra-processed foods in a person’s diet was correlated with a 12% higher risk of cancer. The paper is the first to explore the link between cancer and ultra-pro...
Source: TIME: Health - February 14, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news

Junk food cancer WARNING: Processed products 'may increase risk of cancer'
JUNK foods like ready meals, cakes and crisps may increase the risk of cancer, according to new research yesterday. Experts have issued a health warning over industrially processed products and a disease that kills 162,000 Britons every year. (Source: Daily Express - Health)
Source: Daily Express - Health - February 14, 2018 Category: Consumer Health News Source Type: news

FDA Approves Apalutamide for Nonmetastatic Prostate Cancer FDA Approves Apalutamide for Nonmetastatic Prostate Cancer
This is the first approved therapy for prostate cancer patients who have nonmetastatic, castration-resistant prostate cancer.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA Approves Drug to Help Curb a Tough - to - Treat Prostate Cancer
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 14, 2018 Category: Cancer & Oncology Tags: Nursing, Oncology, Pharmacy, Reproductive Medicine, Research, News, Source Type: news

Web-Based Tool Motivates Teen Cancer Survivors to Exercise Web-Based Tool Motivates Teen Cancer Survivors to Exercise
A web-based interactive tool was successful in increasing physical activity and improving related outcomes among adolescent childhood cancer survivors.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Obesity's Impact on Screening for Cervical Cancer Obesity's Impact on Screening for Cervical Cancer
Dr Andrew Kaunitz highlights an important study, with implications for vaginal examination and cervical cancer screening in obese women.Medscape Ob/Gyn (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 14, 2018 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Commentary Source Type: news

Swiss govt seeks to bar minors from tanning salons
Switzerland's government says minors should be prohibited from using tanning salons because of the long-term skin cancer (Source: ABC News: Health)
Source: ABC News: Health - February 14, 2018 Category: Consumer Health News Tags: Health Source Type: news

Amgen Announces FDA Advisory Committee Meeting To Review Potential New Use Of BLINCYTO ® (blinatumomab)
First-Ever Application to be Submitted for an MRD Positive Indication THOUSAND OAKS, Calif., Feb. 14, 2018 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the Oncologic Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) will review data supporting the BLINCYTO® (blinatumomab) supplemental Biologics License Application (sBLA) for the treatment of patients with minimal residual disease (MRD)-positive B-cell precursor acute lymphoblastic leukemia (ALL) at a meeting on March 7, 2018. MRD refers to the presence of a small amount of detectible cancer cells that remain in the patien...
Source: Amgen News Release - February 14, 2018 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

FDA Approves Erleada (apalutamide) for Non-Metastatic Castration-Resistant Prostate Cancer
February 14, 2018 -- The U.S. Food and Drug Administration today approved Erleada (apalutamide) for the treatment of patients with prostate cancer that has not spread (non-metastatic), but that continues to grow despite treatment with hormone... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 14, 2018 Category: Drugs & Pharmacology Source Type: news

Highly Processed Foods Tied to Higher Cancer Risk
WEDNESDAY, Feb. 14, 2018 -- If you worry about ever getting cancer, you might want to pass on the processed foods at your supermarket. Every 10 percent dietary increase in packaged snacks, fizzy drinks, sugary cereals and other highly processed... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 14, 2018 Category: General Medicine Source Type: news

FDA approves J & J prostate cancer treatment
(Reuters) - The U.S. Food and Drug Administration on Wednesday approved Johnson& Johnson's Erleada treatment for use with prostate cancer patients whose cancer has not spread but continues to grow despite hormone therapy. (Source: Reuters: Health)
Source: Reuters: Health - February 14, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

For one early adopter, CAR T therapy means 18 months cancer-free and counting
For as long as he can remember, Josh Feldman has eagerly embraced the latest technology.Decades ago, his family was the first one on the block with a VCR. Years later, when television went hi-def, he acquired a big-screen TV and signed up for HD service.So after he was diagnosed with lymphoma, it was only natural that Feldman was driven to join clinical trials for a promising new treatment. He would become one of the first UCLA Health patients to receive CAR T therapy. When nothing else worked, the treatment beat back cancer and filled his life with new hope.“Years ago, while doing my own reading after my diagnosis, ...
Source: UCLA Newsroom: Health Sciences - February 14, 2018 Category: Universities & Medical Training Source Type: news

FDA approves new treatment for a certain type of prostate cancer using novel clinical trial endpoint
FDA approves Erleada (apalutamide), first treatment for non-metastatic, castration-resistant prostate cancer (Source: Food and Drug Administration)
Source: Food and Drug Administration - February 14, 2018 Category: American Health Source Type: news

Don't Screen Average-risk Women for Ovarian Cancer
A U.S. Preventive Services Task Force final recommendation issued this week reaffirms that potential harms of routine screening for ovarian cancer outweigh the benefits. The AAFP has agreed in its own recommendation statement. (Source: AAFP News)
Source: AAFP News - February 14, 2018 Category: Primary Care Source Type: news

Digital divide persists with online portals for cancer patients
(Reuters Health) - Even as a growing number of cancer patients are setting up accounts for online access to medical charts, fewer people are actually logging on to look at their test results, a U.S. study suggests. (Source: Reuters: Health)
Source: Reuters: Health - February 14, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Higher Biopsy Rates for Women Undergoing Screening Breast MRI
Lower cancer yield compared to mammography alone for women with, without personal history of cancer (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 14, 2018 Category: Cancer & Oncology Tags: Family Medicine, Gynecology, Internal Medicine, Oncology, Pathology, Radiology, Journal, Source Type: news

New Model Stratifies Patients With Long Bone Metastases
Model includes four prognostic categories with clinical consequences to predict median survival (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 14, 2018 Category: Cancer & Oncology Tags: Oncology, Orthopedics, Pathology, Journal, Source Type: news

DenseBreast-info.org to launch European content
Breast density education group DenseBreast-info.org has announced a plan to...Read more on AuntMinnie.comRelated Reading: DenseBreast-info.org releases Spanish-language video Coalition: Payment for yearly breast screening threatened Breast density groups release resources in Spanish A radiologist confronts her own breast cancer New nonprofit group launches breast density website (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 14, 2018 Category: Radiology Source Type: news

Cabozantinib Active in RAI-Refractory Thyroid Cancer Cabozantinib Active in RAI-Refractory Thyroid Cancer
Cabozantinib has shown activity in the treatment of radioactive iodine-refractory differentiated thyroid carcinoma and could offer an option in addition to sorafenib and lenvatinib.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Swiss gov't seeks to bar minors from using tanning salons
The Swiss government says minors should be barred from using tanning salons because of the long-term risk that radiation from ultraviolet beds could cause skin cancer (Source: ABC News: Health)
Source: ABC News: Health - February 14, 2018 Category: Consumer Health News Tags: Health Source Type: news

' No' to Ovarian Cancer Screening: Harms Outweigh Benefits'No' to Ovarian Cancer Screening: Harms Outweigh Benefits
Women who are not at high risk of developing ovarian cancer should not undergo routine screening, as it will not improve survival but may increase surgical complications, say US experts.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - February 14, 2018 Category: Internal Medicine Tags: Hematology-Oncology News Source Type: news

New Treatment Apalutamide (Erleada) Approved for Prostate Cancer That Resists Hormone Therapy
WEDNESDAY, Feb. 14, 2018 -- Erleada (apalutamide) has been approved by the U.S. Food and Drug Administration to treat non-spreading prostate cancer that continues to grow despite hormone therapy. Prostate cancer is the second-most-common form of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 14, 2018 Category: General Medicine Source Type: news

Bristol-Myers signs record biotech partnership deal
Drugmaker to pay Nektar $1.85bn upfront in hope of boosting cancer immunotherapies (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - February 14, 2018 Category: Pharmaceuticals Source Type: news

New Treatment Approved for Prostate Cancer That Resists Hormone Therapy
WEDNESDAY, Feb. 14, 2018 -- Erleada (apalutamide) has been approved by the U.S. Food and Drug Administration to treat non-spreading prostate cancer that continues to grow despite hormone therapy. Prostate cancer is the second-most-common form of the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 14, 2018 Category: General Medicine Source Type: news

Nektar lands record $3.6B deal with Bristol-Myers Squibb for cancer immunotherapy
Bristol-Myers Squibb (NYSE:BMY) could fork over as much as $3.63 billion for the rights to Nektar Therapeutics‘ (NSDQ:NKTR) cancer immunotherapy drug, according to a deal announced today by the two companies. Nektar’s NKTR-214, which is still in development, is designed to boost the number of cancer-killing T-cells around the tumor’s micro-environment. Bristol-Myers Squibb plans to pair the investigational therapy with its own cancer drug, Opdivo, across more than 20 indications in nine tumor types. Get the full story at our sister site, Drug Delivery Business News. The post Nektar lands record ...
Source: Mass Device - February 14, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Oncology Pharmaceuticals Research & Development Wall Street Beat Bristol-Myers Squibb Co. nektartherapeutics Source Type: news

' Unprecedented' 73% Response Rate With Combo in Untreated RCC'Unprecedented' 73% Response Rate With Combo in Untreated RCC
The combination of an immunotherapy and a VEGF inhibitor for the initial treatment of advanced renal cell carcinoma yielded groundbreaking results. And it is not intolerably toxic.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

FDA Approves Apalutamide (Erleada) to Help Curb a Tough-to-Treat Prostate Cancer
WEDNESDAY, Feb. 14, 2018 -- A new drug that can stall the progression of a particularly hard-to-treat form of prostate cancer has been approved for use by U.S. health officials. In a recent study, the drug called Erleada (apalutamide) has shown... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 14, 2018 Category: General Medicine Source Type: news

FDA Approves Drug to Help Curb a Tough-to-Treat Prostate Cancer
WEDNESDAY, Feb. 14, 2018 -- A new drug that can stall the progression of a particularly hard-to-treat form of prostate cancer has been approved for use by U.S. health officials. In a recent study, the drug called Erleada (apalutamide) has shown... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 14, 2018 Category: General Medicine Source Type: news

New Guidelines for Treating Checkpoint Inhibitor Toxicities New Guidelines for Treating Checkpoint Inhibitor Toxicities
ASCO and the NCCN have issued joint guidelines for treating toxicities associated with checkpoint inhibitor treatment.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

MABp1:'Clever' New Antibody Targeting Colorectal Cancer MABp1:'Clever' New Antibody Targeting Colorectal Cancer
A trial using MABp1, an antibody targeting interleukin 1 alpha, showed some benefit for patients with advanced colorectal cancer, but Dr Kerr thinks the clinical endpoint used was a'little soft. 'Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 14, 2018 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Cairo butcher offers shelter for children with cancer
CAIRO (Reuters) - Three years ago, Cairo butcher Zaza Ogaz decided to do something to help families bringing their children to a nearby cancer hospital. (Source: Reuters: Health)
Source: Reuters: Health - February 14, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Zimbabwe:First Lady's Cancer Campaign Bears Fruit
[The Herald] Over 8 500 women have been screened for cervical cancer nationwide since the First Lady Auxillia Mnangagwa partnered the Ministry of Health and Child Care in a campaign against the disease last week. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 14, 2018 Category: African Health Source Type: news

Liverpool mother diagnosed with pancreatic cancer
Amy Blackrock, of Kirkby, Liverpool, was told she had pancreatic cancer, which kills 90 per cent of patients within five years. Her 'whole world fell apart' when doctors gave her the shock news. (Source: the Mail online | Health)
Source: the Mail online | Health - February 14, 2018 Category: Consumer Health News Source Type: news

Only U.S. Cryotherapy Trial for Mesothelioma Finds Success
Thoracic surgeon Dr. Shanda Blackmon at the Mayo Clinic in Rochester, Minnesota, believes there is a place for cryotherapy in the future multidisciplinary treatment of pleural mesothelioma. She wants to show it with this groundbreaking clinical trial. “We think [cryotherapy] could play an important role in treatment,” Blackmon told Asbestos.com. “So far, things look promising, but you can’t say anything specific without more numbers. Right now, it’s a little like telling a story.” Cryotherapy involves destroying cancer cells, or any abnormal tissues, by freezing them with controlled nitr...
Source: Asbestos and Mesothelioma News - February 14, 2018 Category: Environmental Health Authors: Daniel King Tags: ADI-PEG 20 cryoablation cryotherapy intrapleural measles virus Mayo Clinic mesothelioma clinical trial Opdivo pacific mesothelioma center pleural mesothelioma pleuroscopy Shanda Blackmon Surgery for Mesothelioma After Radiation Thera Source Type: news

Lung cancer symptoms: Seven tell-tale signs you have the deadly disease
LUNG CANCER is one of the most common cancers in the UK - a huge 44,500 people are diagnosed with the disease every year. There are usually no signs in the early stages, but as the condition progresses symptoms will begin to develop. There are seven tell-tale signs you should look out for that indicate you have the deadly disease. (Source: Daily Express - Health)
Source: Daily Express - Health - February 14, 2018 Category: Consumer Health News Source Type: news

Warning from the American Heart Association: Breast cancer treatments, such as radiation and chemo, can cause heart failure
(Natural News) Sometimes the cure is worse than the ailment, the saying goes, and a new warning from the American Heart Association is shedding light on the quandary many women face when weighing breast cancer treatment against the potential side effects. According to the group, some of the most popular breast cancer therapies can actually... (Source: NaturalNews.com)
Source: NaturalNews.com - February 14, 2018 Category: Consumer Health News Source Type: news

Cannabis over chemo: Woman says the oil cured her aggressive breast cancer in 5 months
(Natural News) When Dee Mani, now 44, was diagnosed with breast cancer last March, her doctors suggested chemotherapy. She originally agreed to undergo one year of the treatment for her triple negative breast cancer – the deadliest type – but later had second thoughts. After seeing her sister suffer and die after undergoing chemotherapy for... (Source: NaturalNews.com)
Source: NaturalNews.com - February 14, 2018 Category: Consumer Health News Source Type: news

Bristol-Myers to pay $1.85 billion in cancer deal with Nektar
(Reuters) - Bristol-Myers Squibb Co will pay Nektar Therapeutics $1.85 billion in cash and share purchase for a global development and commercialization deal on a promising Nektar cancer drug, the companies announced on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - February 14, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Cabozantinib potential option to treat differentiated thyroid cancer
According to results that will be presented at the 2018 Multidisciplinary Head and Neck Cancers Symposium in Arizona this Friday, tumours treated with the drug shrunk in 97% of patients.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 14, 2018 Category: Endocrinology Source Type: news

Bristol-Myers To Pay Largest Fee In Biotech History For Nektar Cancer Drug
Bristol-Myers Squibb says it will pay a record $1.85 billion to Nektar Therapeutics, a small biotech startup, for rights to its experimental cancer drug, codenamed NKTR-214. Nektar will book 65% of global profits on the drug, should it reach the market, with Bristol getting the other 35%. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 14, 2018 Category: Pharmaceuticals Authors: Matthew Herper, Forbes Staff Tags: NYSE:BMY NYSE:MRK NASDAQ:NKTR Source Type: news

Lung Cancer Drug Resistance Explained by Computer Simulations
Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib - an anticancer drug used to treat types of lung cancer. Osimertinib binds tightly to a protein, epidermal growth factor receptor (EGFR), which is overexpressed in many tumours. EGFR is involved in a pathway that signals for cell proliferation, and so is a target for drugs. Blocking the action of EGFR (inhibiting it) can switch it off, and so is a good way to treat the disease. (Source: eHealth News EU)
Source: eHealth News EU - February 14, 2018 Category: Information Technology Tags: Featured Research Research and Development Source Type: news