Follow-up phase III data showed Roche ’s Alecensa helped people with ALK-positive metastatic non-small cell lung cancer live a median of almost three years without their disease worsening or death
Roche today announced follow-up data from the phase III ALEX study, showing that, as an initial treatment, Alecensa ® (alectinib) significantly reduced the risk of disease progression or death (progression-free survival; PFS) by 57% (hazard ratio [HR]= 0.43, 95% CI: 0.32-0.58) compared to crizotinib after two years of follow-up in people with anaplastic lymphoma kinase (ALK)-positive metastatic (advanced) non-sm all cell lung cancer (NSCLC), as assessed by the investigator. (Source: Roche Media News)
Source: Roche Media News - May 17, 2018 Category: Pharmaceuticals Source Type: news

Phase III IMpower150 study showed Roche ’s Tecentriq and Avastin plus carboplatin and paclitaxel helped people with a specific type of metastatic lung cancer live significantly longer compared to Avastin plus carboplatin and paclitaxel
Roche today announced positive results from the Phase III IMpower150 study of Tecentriq ® (atezolizumab) and Avastin® (bevacizumab) plus carboplatin and paclitaxel (chemotherapy) for the initial (first-line) treatment of chemotherapy-naïve people with metastatic non-squamous non-small cell lung cancer (NSCLC). (Source: Roche Investor Update)
Source: Roche Investor Update - May 17, 2018 Category: Pharmaceuticals Source Type: news

Phase III IMpower150 study showed Roche ’s Tecentriq and Avastin plus carboplatin and paclitaxel helped people with a specific type of metastatic lung cancer live significantly longer compared to Avastin plus carboplatin and paclitaxel
Roche today announced positive results from the Phase III IMpower150 study of Tecentriq ® (atezolizumab) and Avastin® (bevacizumab) plus carboplatin and paclitaxel (chemotherapy) for the initial (first-line) treatment of chemotherapy-naïve people with metastatic non-squamous non-small cell lung cancer (NSCLC). (Source: Roche Media News)
Source: Roche Media News - May 17, 2018 Category: Pharmaceuticals Source Type: news

Bowel cancer symptoms: Add this popular £1 fruit to your diet to slash risk of disease
BOWEL cancer symptoms are not always easy to spot as they can be mistaken for less serious health conditions. But you can help prevent the disease from developing in the first place by making some simple changes to your diet. Increasing your fibre intake is just of the things you can do. (Source: Daily Express - Health)
Source: Daily Express - Health - May 17, 2018 Category: Consumer Health News Source Type: news

Men ’ s depression may lower chances for pregnancy in couples, NIH study suggests
Women having trouble getting pregnant sometimes try yoga, meditation or mindfulness, and some research suggests that psychological stress may affect infertility. But what about men: Does their mental state affect a couple's ability to conceive? The latest research on this subject was published Thursday in the journal Fertility and Sterility and suggests that a link between mental health […]Related:CDC comes close to an all-clear on romaine lettuce as E. coli outbreak nears historic levelSurrogate mothers ask Supreme Court to stop ‘exploitation’ of women and babiesMore men with low-risk pro...
Source: Washington Post: To Your Health - May 17, 2018 Category: Consumer Health News Source Type: news

Depression in men may lower chances for pregnancy, NIH study suggests
Women having trouble getting pregnant sometimes try yoga, meditation or mindfulness, and some research suggests that psychological stress may affect infertility. But what about men: Does their mental state affect a couple's ability to conceive? The latest research on this subject was published Thursday in the journal Fertility and Sterility and suggests that a link between mental health […]Related:CDC comes close to an all-clear on romaine lettuce as E. coli outbreak nears historic levelSurrogate mothers ask Supreme Court to stop ‘exploitation’ of women and babiesMore men with low-risk pro...
Source: Washington Post: To Your Health - May 17, 2018 Category: Consumer Health News Source Type: news

AgriLife scientists uncover a new face of a famous protein, SWI2/SNF2 ATPase
(Texas A&M AgriLife Communications) A team of Texas A&M and Texas A&M AgriLife Research scientists now have a deeper understanding of a large switch/sucrose non-fermentable (SWI/SNF) protein complex that plays a pivotal role in plant and human gene expression that causes life-threatening diseases such as cancer. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 17, 2018 Category: Biology Source Type: news

New guidelines to help clinicians manage GSM in women with breast cancer
(The North American Menopause Society (NAMS)) Although the genitourinary syndrome of menopause (GSM) is more prevalent in survivors of breast cancer than in other menopausal women, it is commonly undiagnosed and untreated. This led NAMS and ISSWSH to form a multidisciplinary Consensus Panel to develop recommendations for clinicians to manage GSM in women with or at high risk for breast cancer. The recommendations are published online in NAMS' official journal, Menopause. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2018 Category: International Medicine & Public Health Source Type: news

Reading histone modifications, an oncoprotein is modified in return
(American Society for Biochemistry and Molecular Biology) Turning genes on and off is an intricate process involving communication between many different types of proteins that interact with DNA. These communications can go awry, resulting in conditions like cancer. Researchers at the University of Texas MD Anderson Cancer Center have uncovered an unusual form of cross-talk between proteins that affect gene expression, suggesting new ways of inhibiting metastasis in cancer. The findings are published in the Journal of Biological Chemistry. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2018 Category: International Medicine & Public Health Source Type: news

Bone scan software accurately calculates prognosis of advanced prostate cancer
(Duke University Medical Center) A software tool to automatically calculate how extensively bones have been infiltrated by prostate cancer is both accurate and speedy, capturing key prognostic information related to survival and the development of symptoms over time. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

How accurate is breath test for diagnosis esophagogastric cancer?
(JAMA Network) A breath analysis test to diagnose esophagogastric (esophagus or stomach) cancer showed good diagnostic accuracy in a study of 335 patients, including 172 patients already diagnosed with that cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

PharmaMar announces data presentations: Yondelis ® and lurbinectedin at ASCO
(Pharmamar) During the Congress of the American Society of Clinical Oncology (ASCO) that will be held form the June 1-5 in Chicago (USA), PharmaMar will present the data obtained from various clinical studies of the molecules Yondelis ® , lurbinectedin (PM1183) and plitidepsin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

How immune cells kill bacteria with acid
(CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way and kill their prey with acid. However, it is not yet entirely understood how the acidification process is established. In their quest to systematically study proteins that transport chemicals across cellular membranes, researchers at CeMM characterized the critical role for transporter SLC4A7, providing valuable new insights for many pathologic conditions. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

Ovarian cancer drug shows promise in pancreatic cancer patients with BRCA mutation
(University of Pennsylvania School of Medicine) A targeted therapy that has shown its power in fighting ovarian cancer in women including those with BRCA1 and BRCA2 mutations may also help patients with aggressive pancreatic cancer who harbor these mutations and have few or no other treatment options. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

Immune cell provides cradle for mammary stem cells
(Princeton University) Researchers have made new discoveries about how an immune cell known as the macrophage, which normally fights infection by swallowing foreign invaders, nurtures mammary gland stem cells through a chemical signaling molecule. The study may provide important clues about the roles of macrophages in breast cancer progression. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

New blood test rapidly detects signs of pancreatic cancer
(University of California - San Diego) UC San Diego researchers have developed a test that can screen for pancreatic cancer in just a drop of blood. The test, which is at the proof-of-concept stage, provides results in under an hour. It's simple: apply a drop of blood on a small electronic chip, turn the current on, wait several minutes, add fluorescent labels and look at the results under a microscope. If a blood sample tests positive for pancreatic cancer, bright fluorescent circles will appear. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

Stem cell signaling drives mammary gland development and -- maybe -- breast cancer
(University of Pennsylvania) A unique tissue type in many ways, the mammary gland is cloaked in mysteries that scientists puzzle over. In a paper in Science, the University of Pennsylvania's Rumela Chakrabarti and colleagues describe a newly identified connection between mammary stem cells and macrophages, a type of immune cell. The crosstalk between these two cell types is crucial for mammary gland development, and may also figure into the biology of breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

A way to prevent pancreatic cancer from spreading post-surgery?
(Cold Spring Harbor Laboratory) New research suggests a strategy for lowering the odds of metastasis following successful pancreatic cancer surgery: The post-operative period, suggests CSHL Professor Douglas Fearon, 'offers a window during which efforts might be made to keep cortisol levels down and T cells strong so the patient's own immune system can kill the cancer cells that have made their way to other parts of the body but until this point have been dormant.' (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

Innovative light-delivery technique improves biosensors
(The Optical Society) There is a continuing need for practical chip-based sensors that can be used at the point of care to detect cancer and other diseases. An innovative way to inject light into tiny silicon microdisks could help meet this need by bringing down the cost and improving the performance of chip-based biosensors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

Single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia
(Rockefeller University Press) Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 17, 2018 Category: Biology Source Type: news

Improving survival in pancreatic cancer with platinum-based chemotherapy
(Johns Hopkins Medicine) A small study of adults with the most common form of pancreatic cancer adds to evidence that patients with BRCA1 or BRCA2 gene mutations long linked to a high risk of breast cancer have poorer overall survival rates than those without the mutations. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2018 Category: International Medicine & Public Health Source Type: news

Sex, viruses and cancer
(The Ottawa Hospital) A new study suggests that a common treatment for erectile dysfunction combined with the flu vaccine may be able to help the immune system mop up cancer cells left behind after surgery. The study, published in OncoImmunology, shows that this unconventional strategy can reduce the spread of cancer by more than 90 percent in a mouse model. It is now being evaluated in a world-first clinical trial. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2018 Category: International Medicine & Public Health Source Type: news

Hookah responsible for over half of tobacco smoke inhaled by young smokers
(University of Pittsburgh Schools of the Health Sciences) Smoking tobacco from a waterpipe, also known as a hookah, accounted for over half of the tobacco smoke volume consumed by young adult hookah and cigarette smokers in the US, a new University of Pittsburgh School of Medicine analysis discovered. In the US, hookah smoking rates are increasing and cigarette smoking rates are decreasing, especially among young adults. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. We combined SLAM-seq [thiol(SH)–linked alkylation for the metabolic sequencing of RNA], a method for direct quantification of newly synthesized messenger RNAs (mRNAs), with pharmacological and chemical-genetic perturbation in order to define regulatory functions of two transcriptional hubs in cancer, BRD4 and MYC, and to interrogate direct responses to BET bromodomain inhibitors (BETis). We found that BRD4 acts as general coactivator of RNA polymerase II–dependent transcription...
Source: ScienceNOW - May 17, 2018 Category: Science Authors: Muhar, M., Ebert, A., Neumann, T., Umkehrer, C., Jude, J., Wieshofer, C., Rescheneder, P., Lipp, J. J., Herzog, V. A., Reichholf, B., Cisneros, D. A., Hoffmann, T., Schlapansky, M. F., Bhat, P., von Haeseler, A., Köcher, T., Obenauf, A. C., Popow, Tags: Medicine, Diseases, Molecular Biology reports Source Type: news

Men May Gain More From Cancer Immunotherapy
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - May 17, 2018 Category: Cancer & Oncology Source Type: news

CDC comes close to an all-clear on romaine lettuce as E. coli outbreak nears historic level
It's unlikely that anyone currently has edible romaine lettuce that's contaminated with the toxic strain of E. coli bacteria sickening people nationwide since March. That was the message Wednesday from the Centers for Disease Control and Prevention, and if not exactly a thundering signal of “all clear,” it's pretty close. Romaine lettuce has a shelf life of […]Related:Surrogate mothers ask Supreme Court to stop ‘exploitation’ of women and babiesMore men with low-risk prostate cancer are forgoing aggressive treatmentEbola has infected dozens so far in Congo, killing 19, WHO says (Sou...
Source: Washington Post: To Your Health - May 16, 2018 Category: Consumer Health News Source Type: news

Academics and nutritionists confirm olive oil is essential for good health
(Natural News) The jury’s out: Experts have confirmed that olive oil is essential for good health, thanks to its many medicinal properties. In particular, multiple studies have shown that it possesses anti-cancer, anti-inflammatory, antioxidant, immunity-boosting, and overall nutrition-enhancing properties. Olive oil is also beneficial for the heart, and it protects against diabetes and blood pressure, as... (Source: NaturalNews.com)
Source: NaturalNews.com - May 16, 2018 Category: Consumer Health News Source Type: news

Better Responses to Immunotherapy in Men Better Responses to Immunotherapy in Men
When patients with advanced solid tumors are treated with immune checkpoint inhibitors, only men get double the survival benefits seen with standard cancer therapies.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 16, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Obese people are more likely to smoke due to 'addictive' genes drawing them to nicotine
Researchers from the International Agency for Research on Cancer, Lyon, found that for every 4.6kg/m2 increase in BMI, the risk of being a smoker rises by up to 19 per cent, which may be due to DNA. (Source: the Mail online | Health)
Source: the Mail online | Health - May 16, 2018 Category: Consumer Health News Source Type: news

Men Do Better than Women on Cancer Immunotherapies
(MedPage Today) -- Overall survival improvement twice as great, meta-analysis finds (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 16, 2018 Category: Primary Care Source Type: news

Roche immunotherapy combination increases lung cancer survival - study
(Reuters) - Roche's immunotherapy Tecentriq, given with its older drug Avastin and chemotherapy, improved survival of advanced lung cancer patients by about 30 percent over the combination without Tecentriq, according to interim results of a late stage trial released on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - May 16, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Too Few Smokers Get Lifesaving Lung Cancer Tests
Still, guidelines issued by the U.S. Preventive Services Task Force in 2013 say smokers between the ages of 55 and 80 -- whose habit amounts to a pack-a-day for 30 years and otherwise show no symptoms of disease -- should get new low-dose computed tomography (LDCT) screening. (Source: WebMD Health)
Source: WebMD Health - May 16, 2018 Category: Consumer Health News Source Type: news

Good News on Early Breast Cancer: Herceptin Treatment Can Be Shortened
A large, new study shows that the treatment regimen, typically recommended for a year, can be just as effective at 6 months, reducing serious side effects and costs. (Source: NYT Health)
Source: NYT Health - May 16, 2018 Category: Consumer Health News Authors: DENISE GRADY Tags: Breast Cancer Herceptin (Drug) Genentech Inc Earl, Helena M side effects Source Type: news

Too Few Smokers Get Lifesaving Lung Cancer Tests
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 16, 2018 Category: Cancer & Oncology Tags: Oncology, Preventive Medicine, News, Source Type: news

Breast Cancer Patients May Shorten Herceptin Regimen: Study
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 16, 2018 Category: Cancer & Oncology Tags: Gynecology, Oncology, News, Source Type: news

Merck's Keytruda boosts response in hard-to-treat lung cancer
(Reuters) - The combination of Merck& Co's immunotherapy Keytruda and chemotherapy boosted response rates in patients with advanced hard-to-treat squamous cell lung cancer, the company said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - May 16, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

NASCAR driver ’s $1.2M gift supports new pediatric ED, oncology clinic
A $1.2 million donation from NASCAR driver Martin Truex Jr. ’s foundation will help Novant Health expand services in the Charlotte market. Truex, along with partner Sherry Pollex, announced that donation on Wednesday. Those funds will be split to establish two separate ventures — the Novant Health Martin Truex Jr. Foundation Children’s Emergency Dep artment in Huntersville and the SherryStrong Integrative Medicine Oncology Clinic in Charlotte. “They really want to give back and they want… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2018 Category: Biotechnology Authors: Jennifer Thomas Source Type: news

NASCAR driver ’s $1.2M gift supports new pediatric ED, oncology clinic
A $1.2 million donation from NASCAR driver Martin Truex Jr. ’s foundation will help Novant Health expand services in the Charlotte market. Truex, along with partner Sherry Pollex, announced that donation on Wednesday. Those funds will be split to establish two separate ventures — the Novant Health Martin Truex Jr. Foundation Children’s Emergency Dep artment in Huntersville and the SherryStrong Integrative Medicine Oncology Clinic in Charlotte. “They really want to give back and they want… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 16, 2018 Category: Pharmaceuticals Authors: Jennifer Thomas Source Type: news

Loxo Oncology's targeted RET drug shows promise in early trial
CHICAGO (Reuters) - An experimental Loxo Oncology Inc drug that targets cancers with mistakes in the RET gene led to tumor shrinkage in nearly 70 percent of patients regardless of where their cancer originated, according to preliminary data from a small study released on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - May 16, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Testing for all lung cancer mutations at once found cost effective - study
CHICAGO (Reuters) - Testing advanced lung cancer patients for all of the possible genetic mutations that could be driving their cancer at once is more cost effective than testing for one or a limited number of genes at a time, U.S. researchers reported on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - May 16, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Merck KGaA's lung cancer drugs show promise in early-stage trials
FRANKFURT (Reuters) - Germany's Merck KGaA said two of its experimental oncology drugs showed early signs of promise in certain lung cancer patients, potentially helping the company's efforts to find drug-industry partners to share further development costs. (Source: Reuters: Health)
Source: Reuters: Health - May 16, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

A cancer screening flop: Few smokers seek free lung scans
Less than 2 percent of those eligible for lung cancer screening have sought it (Source: ABC News: Health)
Source: ABC News: Health - May 16, 2018 Category: Consumer Health News Tags: Health Source Type: news

Roche breast cancer drug treatment time can be halved - study
(Reuters) - Treating early stage breast cancer patients for just six months with Roche's Herceptin works as well as the current 12-month regimen, researchers who conducted a large clinical trial said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - May 16, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Shorter drug treatment OK for many breast cancer patients
New research suggests that many women with a common and aggressive form of breast cancer that is treated with Herceptin can get by with six months of the drug instead of the usual 12 (Source: ABC News: Health)
Source: ABC News: Health - May 16, 2018 Category: Consumer Health News Tags: Health Source Type: news

For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter
A large, new study shows that the treatment regimen, typically recommended for a year, can be just as effective at 6 months, reducing serious side effects and costs. (Source: NYT Health)
Source: NYT Health - May 16, 2018 Category: Consumer Health News Authors: DENISE GRADY Tags: Breast Cancer Herceptin (Drug) American Society of Clinical Oncology Cambridge University side effects Genentech Inc Source Type: news

First-Line Nelarabine Prolongs T-Cell ALL Remission
(MedPage Today) -- Overall survival of 90% at 4 years is the highest reported yet in these patients (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 16, 2018 Category: Hematology Source Type: news

Radiomics helps distinguish lung cancer nodules on CT
Examining several radiologic features of lung nodules on CT scans enabled radiologists...Read more on AuntMinnie.comRelated Reading: New service tracks incidental lung nodules on CT scans AI can help distinguish lung nodules on CT scans AI, radiomics help distinguish lung nodules on CT scans Deep-learning algorithm can stratify lung nodule risk Nodule count on CT not linked to lung cancer risk (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - May 16, 2018 Category: Radiology Source Type: news

Cancer patient had a tumour on his oesphagus removed by robots
Neil Jones, 56, from Preston, who suffered from aggressive cancer of the foodpipe, was told the muscle between his throat and stomach had to be removed to help cure his condition. (Source: the Mail online | Health)
Source: the Mail online | Health - May 16, 2018 Category: Consumer Health News Source Type: news

Mathematical Modeling May Guide Cancer Treatment & #039;Holidays & #039;
A Moffitt team suggests mathematical modeling may guide the optimal cancer treatment dosing approach better than MTD. (Source: CancerNetwork)
Source: CancerNetwork - May 16, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Breast Cancer Melanoma News Source Type: news

Auto HCT and Matched Sibling Transplant Effective in FL
While HCT is an important benefit for FL patients, the optimal approach remains up for debate. (Source: CancerNetwork)
Source: CancerNetwork - May 16, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Follicular Lymphoma News Source Type: news