Profiling the Development of Gene Therapies at Rejuvenate Bio
Here find a high-level look at the work of Rejuvenate Bio, a gene therapy company aiming to manipulating aging metabolism into a better shape. They have chosen to focus on the strategy of altering tissues to generate signal molecules known to be influential in the progression of aging. This is perhaps the easiest way forward for any gene therapy platform. Gene therapies are clearly the future, but at present it is somewhere between hard, expensive, and impossible to specifically target a gene therapy to most organs or cell types or tissues. If one can use one of the few established approaches, such as delivery of a gene th...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Seeking Success in Science Through NIH-Funded Training
Credit: Courtesy of Hasset Nurelegne. “What’s great about a career in research is that there are so many paths you can take. I get so excited for the future when I think about all the open doors ahead of me,” says Hasset Nurelegne, a senior at Emory University in Atlanta, Georgia. Hasset is majoring in neuroscience and behavioral biology (NBB) as well as English. Since her first year on campus, Hasset has been an active participant in an NIGMS-funded program at Emory that aims to develop a diverse pool of scientists, the Initiative for Maximizing Student Development (IMSD) (which is now just for graduate student...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs

Modeling the Financials of a Drug to Treat Aging
We live in the world in which the regulatory costs imposed on the development of new medicine are enormous. This leads to centralization and regulatory capture. Only the largest entities, the Big Pharma companies, have the funds needed to satisfy the demands of regulators. These companies exist in synergy with the regulators, guiding the regulators (and the politicians backing them) to ensure that (a) their revenue streams are large and stable, and (b) there are fewer challenges to those revenue streams. Big Pharma entities are easily viewed through a cynical lens because their "treating the world, improving lives" rhetori...
Source: Fight Aging! - December 19, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs

Bonus Features – December 17, 2023 – 97% of hospitals now capable of enabling electronic access to patient records, 70% of hospitals face hidden business continuity challenge, plus 31 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News In a blog post, ONC highlighted trends in patient access to electronic health information. Nearly all (97%) hospitals and roughly almost two-thirds (65%) of physician practices are now capable of enabling patient access. Th...
Source: EMR and HIPAA - December 17, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Aaniie American Organization for Nursing Leadership Andor Health Arcadia Healthcare Solutions Avalon Healthcare Solutions AVIA Biofourmis Brett Zelkind Bryan Olson Carallel CAST Software CLEAR CodaMetrix CommonWel Source Type: blogs

Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team. « Back to Top Aged Transplant Organs Cause Harm to Younger Recipients https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/ Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Some Good News To Wrap Up A Rather Mixed Year!
This is a cheering piece of news to wrap up 2023! Cancer vaccine wards off recurrence for up to three years By Natasha Robinson - Health Editor Updated 6:50AM December 15, 2023, The world ’s first cancer vaccine has been found to prevent cancer returning in melanoma patients for as long as three years, new ­results from a major clinical trial show. The cancer vaccine that has been developed (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - December 17, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Recent HHS Settlement Underscores the Importance Compliance Plays in Cybersecurity
The following is a guest article by Dotty Bollinger, JD, Healthcare Compliance Consultant, Compliancy Group The Department of Health and Human Services (HHS) Office for Civil Rights (OCR) reached a settlement with Doctors’ Management Services after the healthcare vendor succumbed to a ransomware attack. The settlement, announced in a press release on the HHS site, resulted in a $100,000 fine, two years of OCR monitoring, and the requirement to adopt a corrective action plan. “Our settlement highlights how ransomware attacks are increasingly common and targeting the health care system. This leaves hospitals and their pa...
Source: EMR and HIPAA - December 13, 2023 Category: Information Technology Authors: Guest Author Tags: Ambulatory Health IT Company Healthcare IT Hospital - Health System LTPAC Regulations Security and Privacy 21CO 21st Century Oncology AMCA American Medical Collection Agency Compliancy Group Cyberattacks Cybersecurity Departmen Source Type: blogs

Science Snippet: Zooming In on Nanoparticles
Nanoparticles come in many different shapes and configurations. Credit: Adapted from Stevens, et. al., under Creative Commons License 4.0. Nanoparticles may sound like gadgets from a science fiction movie, but they exist in real life. They’re particles of any material that are less than 100 nanometers (one-billionth of a meter) in all dimensions. Nanoparticles appear in nature, and humans have, mostly unknowingly, used them since ancient times. For example, hair dyeing in ancient Egypt involved lead sulfite nanoparticles, and artisans in the Middle Ages added gold and silver nanoparticles to stained-glass windows. Over...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 13, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Cool Videos Medicines Science Snippet Source Type: blogs

From advocacy to early cancer detection
I write widely as a patient advocate and subject matter expert on public policy for the regulation of prescription opioid analgesics in pain medicine. Like many people younger than myself, I also visit many social media platforms almost daily. I am active on these platforms to share recent health care news and to support hope Read more… From advocacy to early cancer detection originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 13, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

An eye surgeon ’ s unexpected finding: a brain tumor diagnosis
In medicine, the sickest patients always seem to come on Friday afternoons. At the end of the week, I’m hoping to move quickly through my last few patients – a small corneal abrasion, a routine follow-up, or a stable glaucoma exam. I’m prepared for a pleasant conversation and some friendly banter about rival football teams Read more… An eye surgeon’s unexpected finding: a brain tumor diagnosis originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 12, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

RSNA Panel Emphasizes Link Between Radiology and Quadruple Aim
A panel of radiology experts at RSNA23 put the spotlight on the important role radiology plays in achieving the quadruple aim. The panelists unanimously agreed that radiologists have a significant impact on a patient’s care journey and population health. At the 2023 RSNA Conference in Chicago, PocketHealth hosted a lunch and learn event on Day 1. This special event featured a panel of radiology and data sharing experts: Rishi Nayyar – Co-Founder & CEO at PocketHealth (moderator) Aimee Langan – Director, Diagnostic Imaging and Laboratory Services at William Osler Health System Ajay Kohli, MD, MBA – ...
Source: EMR and HIPAA - December 12, 2023 Category: Information Technology Authors: Colin Hung Tags: Health IT Company Healthcare IT HIM Hospital - Health System Interoperability Aimee Langan Ajay Kohli Frank Manole Image Exchange PocketHealth Population Health Quadruple Aim Radiology Radiology IT Raleigh Radiology Ram Chada Source Type: blogs

Meta-Analysis Suggests Aspirin Use Reduces Risk of Cancer Mortality
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team. Link: https://doi.org/10.1038/s41416-023-02506-5 (Source: Fight Aging!)
Source: Fight Aging! - December 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Aranscia Acquires YouScript from Invitae
Aranscia, a global provider of diagnostics software, services, and testing solutions, and Invitae Corporation, a leading medical genetics company, today announced that Aranscia has acquired select assets of the YouScript personalized medication management platform from Invitae Corporation in an all-cash transaction. YouScript is a widely recognized leader in providing actionable, real-time medication risk and pharmacogenomics (PGx) insights that enable healthcare providers and organizations to build, deliver, and scale comprehensive personalized medication management programs. YouScript’s foundational peer-reviewed resea...
Source: EMR and HIPAA - December 11, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 2bPrecise AccessDX Laboratory Aranscia Health IT Acquisitions Healthcare M&A Invitae Corporation Joe Spinelli Kristine Ashcraft SinguLab YouScript Source Type: blogs

Toll-Like Receptors React to Molecular Damage to Contribute to the Inflammation of Aging
This review paper covers what is known of toll-like receptors in the development of age-related chronic inflammation, with a particular focus on toll-like receptor 4 (TLR4). A sizable number of researchers are focused on finding ways to suppress the constant overactivation of the immune system in later life by interfering in its regulation. Unfortunately, the sensing mechanisms involved are also required for normal immune function, so it is hard to envisage even sophisticated implementations of this strategy producing therapies that don't inhibit necessary immune functions, such as defense against pathogens and destruction...
Source: Fight Aging! - December 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

An update from TAB
TAB sent this (see below) as a comment to his older news post, but I decided to put it in a post so more readers will see it immediately. TAB, you are amaaaaazing! A big hug! Margaret.   Here’s his message: TAB’s Update December 8, 2023 Alive and well at age 82 after dealing with MM (IgA Lambda) for 25 years. I have been off Velcade treatment for a year. I am feeling good with no symptoms. I am taking 6 grams of curcumin, resveratrol, vitamins C and D, selenium and a multivitamin. My blood work is good but M spike is rising. I will probably be going back on Velcade in February 2024 if the M spike keeps rising. My ...
Source: Margaret's Corner - December 10, 2023 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs