Evolution of targeted cancer therapies: a radiation oncologist ’ s perspective
On July 1, 1987, I started treating cancer patients as a full-time radiation oncologist – a cancer specialist who uses radiation therapy to help cancer patients beat their disease. Now, nearly 37 years later, I have the privilege of caring for cancer patients at a cancer center. Nearly every type of cancer is treated differently;
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Evolution of targeted cancer therapies: a radiation oncologist’s perspective originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 2, 2024 Category: General Medicine Authors: Kevin L. Schewe, MD Tags: Conditions Oncology/Hematology Source Type: blogs
Common pitfalls underlying cause-and-effect relationships
In the realm of medicine, cause-and-effect relationships are those where a specific cause, such as a disease, condition, or treatment, directly leads to a specific outcome or effect. An example of this is the established fact that smoking causes lung cancer. Similarly, it is well-documented that regular, heavy alcohol consumption directly leads to liver cirrhosis.
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Common pitfalls underlying cause-and-effect relationships originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 1, 2024 Category: General Medicine Authors: Arthur Lazarus, MD, MBA Tags: Physician Psychiatry Source Type: blogs
Palliative and hospice care in hospitals and clinics: the good, the bad, and the ugly
I walk into the patient’s hospital room during evening rounds. He looks pale and tired, having recently completed a round of chemotherapy for his stage IV pancreatic cancer. His wife is at the bedside, scared and concerned about her husband’s rapid decline. I sit down to discuss goals of care when the patient immediately says,
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Palliative and hospice care in hospitals and clinics: the good, the bad, and the ugly originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 1, 2024 Category: General Medicine Authors: Earl Stewart, Jr., MD & Efferocytosis in the Context of Aging and Age-Related Disease
There is something of a tradition in the aging research community of writing reviews that attempt to summarize everything that is known of a single specific cellular behavior in the context of the panoply of cell and tissue dysfunction observed in aging. Today it is the turn of efferocytosis, the clearance of dying cells and their immediate debris by phagocytes such as macrophages of the innate immune system. It is fairly straightforward to mount an argument to suggest that more efficient efferocytosis is a good thing, as unwanted consequences attend the presence of lingering cell corpses cluttering up tissue. Like autopha...
Source: Fight Aging! - April 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Beyond safety whistles and pizza: On National Doctor ’s Day and every day, physicians deserve humanity
Recently, on an average workday, my hand brushed against the small safety whistle clipped beside my ID badge. Most days, I don’t even remember the whistle is there, a “Happy Doctor’s Day” gift from a few years ago. I dutifully clipped it on, but I can’t say it makes me feel safer. I remember shrugging
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Beyond safety whistles and pizza: On National Doctor’s Day and every day, physicians deserve humanity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 30, 2024 Category: General Medicine Authors: Jennifer Lycette, MD Tags: Physician Oncology/Hematology Source Type: blogs
A Skeptical View of the Role of Nuclear DNA Damage in Aging
It is evident and settled that stochastic nuclear DNA damage contributes to cancer. The more of it that you have, the worse your risk. What is still very much debated is whether nuclear DNA damage contributes meaningfully to degenerative aging, and how it does so. Most mutational damage to DNA occurs in regions that are inactive, in cells that have comparatively few divisions remaining before reaching the Hayflick limit. Even if damage alters the function of such a cell, in some non-cancerous way, it is unclear as to how this could amount to a meaningful contribution to loss of tissue function.
The one school of tho...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Advantages, Challenges, and Costs of Healthcare at Home Services
Switching to fully remote operations during the pandemic was a rushed adventure into what was mostly uncharted territory. There were a lot of challenges and bugs to work out, but there were also plenty of advantages and unforeseen benefits. And it is thanks to those advantages and benefits that healthcare at home is continuing, even as there are still challenges to work on and in-person operations return. While our first big push into remote care was a leap into the unknown, this time we want to make sure that we are surveying the landscape to make this a safe, smart, and financially responsible decision.
So let’s ta...
Source: EMR and HIPAA - March 28, 2024 Category: Information Technology Authors: Grayson Miller Tags: Clinical Health IT Company Healthcare IT Hospital - Health System LTPAC Revenue Cycle Management Telemedicine and Remote Monitoring Alaina Victoria Ash Wellness Brenden Hayden Carenet Health Carium Chris Darland David McCormick Source Type: blogs
Princess and the pauper: Both deserve health privacy
The sad news of Princess Kate Middleton’s cancer diagnosis is a sound reminder of the sanctity of a person’s health status and their right to privacy. I wasn’t sure which adjective I should use to describe Kate’s diagnosis – “sad,” “tragic,” or “devastating.” All are equally true, depending on whose perspective you consider. No doubt
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Princess and the pauper: Both deserve health privacy originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 28, 2024 Category: General Medicine Authors: Arthur Lazarus, MD, MBA Tags: Physician Mainstream media Source Type: blogs
Case report: regression of MGUS with long-term use of curcumin!
I wonder if these case reports will ever catch the eye of our MM organisations, which, unfortunately, are so heavily sponsored by big Pharma…Doubtful…
Well, Margaret, this is intended to be a celebratory post, and I really don’t have the energy to dive into THAT discussion again. It’s just so bloody frustrating that sometimes I have to let off some steam. But no, not today. Today is a super good day!
Pinga, 14.5 years old
A new case report, led by Terry Golombick (if you don’t know who she is, you can do a search of my blog…she’s one of my favourite people on the planet…!!...
Source: Margaret's Corner - March 27, 2024 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll case report on curcumin MGUS patient and curcumin Terry Golombick Source Type: blogs
Interesting Epidemiological Results for Time Restricted Feeding
In this study, researchers investigated the potential long-term health impact of following an 8-hour time-restricted eating plan. They reviewed information about dietary patterns for participants in the annual 2003-2018 National Health and Nutrition Examination Surveys (NHANES) in comparison to data about people who died in the U.S., from 2003 through December 2019, from the Centers for Disease Control and Prevention's National Death Index database.
The analysis found: (a) people who followed a pattern of eating all of their food across less than 8 hours per day had a 91% higher risk of death due to cardiovascular d...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Apigenin, Sleep, and Aging
For those following research into efforts to upregulate NAD+ levels to improve mitochondrial function, this paper is an interesting sidebar. Some degree of loss of NAD+ emerges from increased activity of CD38. Apigenin is a dietary supplement that can modestly influence both sleep and pace of aging, the latter in short-lived laboratory species at least. Apigenin can increase NAD+ levels by inhibiting CD38 activity. Like much of metabolism, this is all very interesting, but the effect sizes are nothing to write home about. If upregulating NAD+ levels is the goal, you'll do better by exercising. The fundamental flaw in so mu...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKK4 Inhibition Provokes Greater Liver Regeneration
Researchers here report on an approach to meaningfully stimulate the regenerative capacity of the liver. The liver is one of the few organs capable of significant regrowth in mammals, and the way in which it does so is quite different from the regenerative response found in other tissues. Thus while the results here are quite impressive, they don't apply to other organs. This is purely a way to manipulate the regulation of liver regeneration.
One key feature of acute and chronic liver diseases, and after extended liver resections, is the inability of hepatocytes to sufficiently regenerate and restore or maintain a...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fever!!!
My faithful nurses (of course, Stefano was number ONE)…
I’m usually soooo careful when I leave the house…If I’m going to be in a crowded situation, such as a supermarket, I pull out and wear an FFP2 mask. I don’t shake hands or kiss anyone, even my closest friends. They all know and respect that…
But on Sunday, March 10, I let down my guard, unfortunately. We went to a friend’s house, and when we left, I gave her a hug, just as she was telling me that she didn’t feel that great (Margaret, duh!). We pulled apart, but the damage was done. The following day she came down with a ...
Source: Margaret's Corner - March 25, 2024 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
