Hidden truths and medical intrigue [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Jennifer Lycette, a novelist and rural hematology-oncology physician. We discuss Jennifer’s latest work, The Committee Will Kill You Now, a novel that explores the dark side of the medical world, ethics, and the enduring impact of hidden secrets. Join us as we unravel
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Hidden truths and medical intrigue [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 28, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Oncology/Hematology Source Type: blogs
Ring In the New Year With Basic Research
Empowering basic biomedical research, which focuses on understanding how living systems work, is one of NIGMS’ main goals. This type of research not only helps us learn how our bodies and those of other organisms function but also lays the foundation for advances in disease diagnosis, treatment, and prevention.
We’re excited to see what the upcoming year has in store for the field! In preparation, we’re highlighting what NIGMS-supported scientists had to say in 2023 about the many merits of basic research. Also check out the links to the Biomedical Beat posts that feature them if you haven’t already.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 27, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Scientific Process Source Type: blogs
From fear to empowerment: Beating breast lump anxiety [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Tami Burdick, a patient advocate and the author of Diagnosis Detective: Curing Granulomatous Mastitis. Tami shares her personal journey with granulomatous mastitis (GM) and how she navigated the fear of a breast lump. Discover the relationship between GM and breast cancer risk, practical
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From fear to empowerment: Beating breast lump anxiety [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 27, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Oncology/Hematology Source Type: blogs
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Senescent cells are created throughout the body at all stages of life, largely when somatic cells reach the Hayflick limit on replication. Senescent cells cease replication and begin to energetically produce pro-growth, pro-inflammatory factors, attracting the attention of the immune system and otherwise changing the behavior of surrounding cells. Cell stress and mutational damage can induce senescence, and in this case senescence is a mechanism that acts to limit the risk of cancer. Tissue injury also produces senescent cells, and here they help to coordinate the activities of the many different cell types that become inv...
Source: Fight Aging! - December 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Benefits of Semaglutide in Heart Failure are not Just Due to Weight Loss, in Mice at Least
This study investigated semaglutide, a glucagon-like peptide-1 receptor agonist that induces significant weight loss in patients with obesity and/or type 2 diabetes mellitus and has been associated with improved cardiovascular outcomes.
In a mouse model of HFpEF that was caused by advanced aging, female sex, obesity, and type 2 diabetes mellitus, semaglutide, compared with weight loss induced by pair feeding, improved the cardiometabolic profile, cardiac structure, and cardiac function. Mechanistically, transcriptomic, and proteomic analyses revealed that semaglutide improved left ventricular cytoskeleton function a...
Source: Fight Aging! - December 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Uncovering the truth behind my father ’ s tragic end
I was the “stranger” at my father’s bedside. Shortly after his 84th birthday, my father fell and landed in the hospital with a split scalp. His metastatic prostate cancer was an incidental finding, and superimposing this wildly invasive tumor on his Parkinson’s-compromised body marked his first steps onto his death path. I came to my
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Uncovering the truth behind my father’s tragic end originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 24, 2023 Category: General Medicine Authors: Robin Downing, DVM Tags: Conditions Palliative Care Source Type: blogs
Bonus Features – December 24 , 2023 – 74% of orgs automating RCM operations, per-physician revenue exceeding expenses at U.S. hospitals, plus 19 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
Median hospital margins rose to 2% in November, according to the latest data from Syntellis, and per-physician revenue growth is outpacing per-physician expenses.
Nearly 3 in 4 (74%) healthcare organizations ar...
Source: EMR and HIPAA - December 24, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Accelecom Akasa Avel eCare Ayble Health Boston Children's Hospital Brightside Health Butterfly Network Cancer Moonshot Clarify Health Commure Engage Data Dimensions Digital Medicine Society Greenway Health Healthc Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Happy Holidays!
Hello everyone! Time is really flying…it’s Xmas, already??? How did that happen? Anyway, I just wanted to wish you all a very happy and healthful and peaceful holiday…
Just about an hour ago I read some interesting news on the curcumin front, positive news…unfortunately, I don’t have time to write about it now. But I will be looking into it, you can be sure of that…
In the meantime…
Buone Feste, Happy Holidays! Margaret (Source: Margaret's Corner)
Source: Margaret's Corner - December 24, 2023 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
Sizes of Immune Cell Subsets Correlate with Human Mortality
In this study, we found that T cells and natural killer (NK) cells with low expression of CD56 were inversely associated with mortality while neutrophils were positively associated with mortality. In addition, we found myeloid dendritic cells to be nominally associated with a reduced odds of mortality, and CD4+ effector memory T cells and IgD- memory B cells to be nominally associated with increased mortality odds.
Several previous studies have shown a positive association between neutrophils and mortality and our study confirmed these previous findings. The number of neutrophils are preserved in older adults though...
Source: Fight Aging! - December 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Nectandrin B Extends Life in Flies
In this study, we present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. This result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related d...
Source: Fight Aging! - December 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Profiling the Development of Gene Therapies at Rejuvenate Bio
Here find a high-level look at the work of Rejuvenate Bio, a gene therapy company aiming to manipulating aging metabolism into a better shape. They have chosen to focus on the strategy of altering tissues to generate signal molecules known to be influential in the progression of aging. This is perhaps the easiest way forward for any gene therapy platform. Gene therapies are clearly the future, but at present it is somewhere between hard, expensive, and impossible to specifically target a gene therapy to most organs or cell types or tissues. If one can use one of the few established approaches, such as delivery of a gene th...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Seeking Success in Science Through NIH-Funded Training
Credit: Courtesy of Hasset Nurelegne.
“What’s great about a career in research is that there are so many paths you can take. I get so excited for the future when I think about all the open doors ahead of me,” says Hasset Nurelegne, a senior at Emory University in Atlanta, Georgia. Hasset is majoring in neuroscience and behavioral biology (NBB) as well as English.
Since her first year on campus, Hasset has been an active participant in an NIGMS-funded program at Emory that aims to develop a diverse pool of scientists, the Initiative for Maximizing Student Development (IMSD) (which is now just for graduate student...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Modeling the Financials of a Drug to Treat Aging
We live in the world in which the regulatory costs imposed on the development of new medicine are enormous. This leads to centralization and regulatory capture. Only the largest entities, the Big Pharma companies, have the funds needed to satisfy the demands of regulators. These companies exist in synergy with the regulators, guiding the regulators (and the politicians backing them) to ensure that (a) their revenue streams are large and stable, and (b) there are fewer challenges to those revenue streams. Big Pharma entities are easily viewed through a cynical lens because their "treating the world, improving lives" rhetori...
Source: Fight Aging! - December 19, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
