From fear of loneliness to embracing solitude
Young children have different hobbies and preferences while playing in every part of the world. Some things are universal, but many are influenced by the culture of that specific area or the living conditions of that family. In the subcontinent, young girls are very fond of playing with dolls. Most of the time, these dolls
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From fear of loneliness to embracing solitude originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 25, 2024 Category: General Medicine Authors: Dr. Damane Zehra Tags: Physician Oncology/Hematology Source Type: blogs
Estrogen-Related Receptor Agonists as Exercise Mimetic Drugs
Just as the research community is interested in finding pharmaceutical ways to provoke some the beneficial reactions to calorie restriction, there is also considerable effort devoted to the search for drug candidates that can mimic some of the benefits of exercise. If the history of calorie restriction mimetic drug development is any guide, this will be a slow process, and the resulting compounds will produce lesser benefits than actual exercise, as they will only touch on a small subset of the processes involved. Still, there is no shortage of programs in this space, and here is one example.
Exercise benefits bot...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Palpitations and presyncope in a 40-something
Discussion: Putting all of the information together this patient is most likely suffering from arrhythmogenic cardiomyopathy (AC) better known as ARVC. The medical hx is typical, with sudden onset tachydysrhythmia during physical exertion. It is not uncommon for the initial presentation to be sudden cardiac death (SCD). In fact it is one of the leading causes of SCD in people age less than 40 years. Thus it is very important to identify this disorder. AC is a disease in which myocardium is replaced by fibrofatty tissue. This usually and predominantly affects the RV free wall and apical regions, but it can affect the left v...
Source: Dr. Smith's ECG Blog - March 24, 2024 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Ret-He: Reticulocyte hemoglobin equivalent – Marker for iron deficiency in ADHF
It is well known that iron deficiency is associated with poor outcome in acute decompensated heart failure. Different criteria like serum ferritin less than 100 ng/mL or 100-299 ng/mL with transferrin saturation less than 20% have been used to define iron deficiency. Inflammation which is common in heart failure may hinder serum ferritin values [1]. Another marker which has been proposed is reticulocyte hemoglobin equivalent (Ret-He) which is thought to reflect the iron content in reticulocytes.
In a study of 225 patients with ADHF from Japan, median left ventricular ejection fraction was 37%. Median hemoglobin level was ...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Transforming Clinical Quality & Value in Rehabilitation with Neurocognitive Technology
The following is a guest article by Jared Gillespie, Senior Director of Clinical Solutions at Academy Medtech Ventures (AMV)
In the landscape of rehabilitative care, the integration of neurocognitive technology stands as a beacon of innovation, charting a course toward improved clinical quality and patient outcomes. This journey into the brain’s potential within rehabilitation not only elevates the standard of care but also underscores the role of advanced technologies in shaping the future of healthcare.
Traditional rehabilitative care has predominantly focused on physical recovery, often overlooking the brain’...
Source: EMR and HIPAA - March 22, 2024 Category: Information Technology Authors: Guest Author Tags: Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Academy Medtech Ventures AMV Clinical Quality Healthcare Transformation Jared Gillespie Neurocognitive Technology rehabilitative c Source Type: blogs
A doctor ’ s journey: from student to healer, facing a mentor ’ s illness
I had a teacher in my third year of med school. His name was Dr. T. He taught us pediatrics. At that time, he was the head of the department of pediatrics in the busiest teaching hospital in our city, where I was working. Every day, hundreds of children from far-flung areas are referred to
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A doctor’s journey: from student to healer, facing a mentor’s illness originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 20, 2024 Category: General Medicine Authors: Dr. Damane Zehra Tags: Conditions Oncology/Hematology Source Type: blogs
Aspects of Skin Aging Encourage Metastasis in Melanoma
There are many ways in which the aging of tissue makes cancer both more likely to occur and more aggressive once it does occur. Here researchers focus in on specific changes in aged skin tissue that make melanoma cancers more likely to become metastatic and spread to other organs. Interestingly, it is an indirect effect on cell signaling that is mediated by increased stiffness of the skin extracellular matrix, an issue in many aging tissues that has many root causes, not just the one noted here. Nonetheless, if metastasis could be shut down, then cancer would become a much more tractable problem, particularly if control of...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
This study provides some insight into how these relationships play out in practice by sabotaging telomerase and p53, and observing the results.
Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence. These processes reduce cell proliferation and disrupt tissue homeostasis, thus contributing to systemic aging. Similarly, zebrafish have restricted telomerase expression, and telomeres shorten to critical length during their lifesp...
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inside the cancer waiting room where hope hangs in the balance
I sat there, frozen in time, full of fear, full of anxiety. Waiting for my time to “face the music,” but this wasn’t a dance party. My fellow patients, complete strangers, were seated about me, and each of us kept a safe distance apart from each other—a carry-over from the pandemic, I guess. All of
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Inside the cancer waiting room where hope hangs in the balance originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 17, 2024 Category: General Medicine Authors: Michele Luckenbaugh Tags: Conditions Oncology/Hematology Source Type: blogs
Three Ways AI, If Trusted, Can Transform the Healthcare Landscape
The following is a guest article by Jeanne Greathouse, Healthcare Development Director, AI Regulatory Services at BSI
77% of Healthcare Workers Say They May Be Ready to Let AI Take on Administrative Work
Few industries have been stress-tested as thoroughly as the healthcare system during COVID-19 when, at the worst moments, 22% of US hospitals were reporting staff shortages. Even three years on, the World Health Organization found that 84% of countries were still experiencing some disruption. Amid a period of tremendous medical uncertainty and service disruption, health workers and first responders functioned like a life v...
Source: EMR and HIPAA - March 15, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Artificial Intelligence BSI Healthcare Efficiency Healthcare Transformation Improving Patient Care Jeanne Greathouse Medical Innovation Source Type: blogs
Reviewing the Path Towards Reprogramming as a Basis for Rejuvenation Therapies
In conclusion, while partial reprogramming holds great therapeutic potential, the real focus should be on rejuvenation research, defining its nature and ways to quantify it. Another critical issue is the ability to quantify biological age as reprogrammed older cells acquire younger states. Understanding rejuvenation is also key to translational success, as benefits of age reversal must be considered against risks. More research into safety and tissue-specific responses of this technique are required. (Source: Fight Aging!)
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
SOX17 Allows Early Stage Colon Cancer to Evade the Immune System
Researchers here report on work that identifies SOX17 inhibition as a potential way to attack colon cancer in its early stages. Any successful cancer must have adopted one or more ways to suppress the immune system in order to grow past the earliest stages of a few cancerous cells. Interfering in those suppression mechanisms is a potential basis for therapy, as the researchers demonstrated here. Whether or not this line of work will make much further depends on whether an economically viable approach to SOX17 inhibition can be found, and whether or not it is a good target for many other forms of cancer.
Colon canc...
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Science Snippet: Examining Enzymes
Structure of a pyruvate kinase, an enzyme that adds a phosphate group to adenosine diphosphate (ADP) to make adenosine triphosphate (ATP). Credit: PDB 7UEH.
Every day, our cells must produce all the various molecules they need to stay alive. But the chemical reactions to create these molecules can’t occur without help—which is where enzymes come in. Enzymes are biological catalysts, meaning they speed up the rate of specific chemical reactions by reducing the amount of energy needed for the reaction to occur. Most enzymes are proteins, but some RNA molecules can also act as enzymes.
Thousands of different enzymes ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 13, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes Proteins Science Snippet Source Type: blogs
Optimism on the Timeline for Extending Human Lifespans by 20 Years or More
In the interview noted here, Aubrey de Grey of the Longevity Escape Velocity (LEV) Foundation makes a bold prediction of 12-15 years as to when we might see the advent of the first therapies capable of extending the healthy human life span by a few decades, allowing older people to live long enough to benefit from following improvements to further extend their healthy life spans. It is worth bearing in mind that the creation of novel therapies doesn't mean widespread use or even easy availability of those therapies. Further, it is unlikely that we'll know the effects on human life span of any given combination of novel rej...
Source: Fight Aging! - March 11, 2024 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
