Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On Balance, Vegetarians Exhibit Better Biomarkers than Non-Vegetarians
There is a fair amount of epidemiological data to suggest that vegetarians have, on balance, better long-term health prospects than people who consume meat. The usual caveats apply, in that vegetarianism in many wealthier study populations is correlated with a range of other potentially relevant line items, such as education, wealth, and better lifestyle choices. Further, the average vegetarian may well be mildly calorie restricted in comparison to the average meat eater, and that may be enough in and of itself to explain health effects. Other suggested contributing factors include dietary advanced glycation end-products, ...
Source: Fight Aging! - May 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What are these ST elevations, ST depressions, and tall T waves diagnostic of?
Written by Pendell MeyersLet ' s see this presentation ECG without any context first (no baseline ECG was available)What do you think? What will you do?The ECG is diagnostic of severe hyperkalemia. There is sinus tachycardia, the beginning of QRS widening, tall pointy peaked T waves with little area compared to their height. There is STE in V1-V3, aVR, and aVL, with STD in II, III, aVF, V4-V6. The appearance in V1 is similar to the Brugada morphology (as is often the case in hyperkalemia and Na channel blocker effects causing STE). Together these ST elevations in the right precordial leads and aVL are classic pseudoS...
Source: Dr. Smith's ECG Blog - May 14, 2021 Category: Cardiology Authors: Pendell Source Type: blogs
Light-Responsive Hydrogel to Fill Cerebral Aneurysms
Researchers at Pohang University of Science & Technology (POSTECH) in Korea have developed a new technique to treat cerebral aneurysms. Described in journal Advanced Materials, the treatment involves using a catheter to deliver an alignate hydrogel that is crosslinked in place within the aneurysm using light. The hydrogel is not degradable and can reside within the body for extended periods. As an alternative to coil embolization, the hydrogel stabilizes the aneurysm and reduces the chance of it bursting.
Cerebral aneurysms form when a weak spot in a cerebral artery balloons out, putting pressure on nearby ti...
Source: Medgadget - May 12, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Neurology Neurosurgery Vascular Surgery POSTECH Source Type: blogs
What is an Intermediate coronary lesion & What shall we do with it ?
This question might squeeze the collective coronary knowledge of any cardiologist. (At least, it does for me !)
What is an intermediate coronary lesion? (ICL)
Traditionally it is an “angio-ocular reflex” measurement of coronary arterial diameter stenosis that lies between 40 to 70% (Mind you, 70 diameter stenosis is 90% area. So,we must be clear what we really mean in any revascularisation debate).
Above one is the simplest expression of ICL. (* While 70% cutoff is fairly constant, the lower limit 40% is still not a settled issue. It can even be 30 %. I think we haven’t yet named th...
Source: Dr.S.Venkatesan MD - April 25, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized diameter vs area stenosis fame s fame study ffr ifr qfr intermediate coronary lesion minimal cad coronary erosion what is intermediate coronary lesion ? Source Type: blogs
VITAL trial on vitamin D
Role of vitamin D in cardiovascular disease has been suggested by observational studies. Low blood levels of vitamin D was found to be associated with higher risks of heart disease, stroke, hypertension and diabetes mellitus [1]. But the 2011 Institute of Medicine (United States) guidance concluded that the evidence is inconsistent and inconclusive, not meeting the criteria for a cause effect relationship [2].
VITAL study was a randomized placebo controlled trial of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and omega-3 fatty acids at a dose of 1 g per day for prevention of cancer and cardiovascular diseas...
Source: Cardiophile MD - April 18, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, April 5th 2021
In this study, the research team designed a way to identify small molecules that improve the function of ABCA1 in the body while avoiding unwanted effects to the liver. The researchers honed in on a specific small molecule, CL2-57, due to its ability to stimulate ABCA1 activity with positive effects on liver and plasma triglycerides. The use of this compound showed improved glucose tolerance and insulin sensitivity, as well as reduced weight gain, among other beneficial effects.
Age-Related Upregulation of Autophagy as a Possible Contribution to Bat Longevity
https://www.fightaging.org/archives/2021/04/age-rel...
Source: Fight Aging! - April 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Z va score in Aortic stenosis : No more a theoretical concept
It was the final case on weekend Echocardiogram review day, I asked my fellow for a brief summary of the patient. A 3 minute conversation“Yes, sir, he is a 62-year-old male retired govt officer. He has a severely stenosed aortic valve, with a peak gradient of 90 mmHg and a mean gradient that comes to almost 50 mmHg. LV EF is 58%, GLS is 18, LVH is obvious. LA is not dilated (Didn’t measure volume though), but DT is short. Valve orifice is hovering around 1cm, mild calcium noted in LCC I am not sure whether it’s bi or tricuspid still. The annulus is 22mm. The mitral valve is perfect, no calcium spill ...
Source: Dr.S.Venkatesan MD - April 4, 2021 Category: Cardiology Authors: dr s venkatesan Tags: aortic stenosis Aortic valve replacement asymptomatic severe aortic stenosis tavr vs savr for aortic stenosis zva score in aortic stenosis Source Type: blogs
7 Tips To Help With Insomnia Naturally And Quickly
A healthy lifestyle revolves around the daily habits and dietary aid you include in your life. It is one of the significant factors behind long-term wellness and disease-free life. If you wish to enhance your lifestyle, you must be willing to make the essential changes. From the excessive intake of sugar-laden snacks to your meals’ timing, everything affects your health in the long run. Also, it contributes to lack of sleep and constant sleep disturbances now and then. But, you can get rid of the signs of insomnia with minimal lifestyle changes and natural aids.
Here are the top ways in which you can achieve a refresh...
Source: PickTheBrain | Motivation and Self Improvement - April 2, 2021 Category: Consumer Health News Authors: Rebecca R Tags: depression featured health and fitness self-improvement health benefits of sleep insomnia pickthebrain Source Type: blogs
Tau Knockout in Normal Mice Improves Mitochondrial Function and Slows Cognitive Decline
Tau is involved in Alzheimer's disease and other tauopathies; it is one of the few proteins in the body capable of becoming naturally altered in ways that encourage aggregation of the protein into solid deposits that are toxic to cells. Tau is highly expressed in nerve cells, and helps in the function of the microtubule network of the cell. It also has roles in other processes peculiar to nerve cells, such as synaptic transmission. Mice lacking tau exhibit issues with regulation of insulin metabolism and behavior. That isn't preventing the exploration of lowered tau levels as a basis for therapies to treat Alzheimer's dise...
Source: Fight Aging! - April 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
4 essential nutrients — are you getting enough?
The newest dietary guidelines for Americans say that many Americans don’t get enough of four vital nutrients. Over time, a shortfall of these nutrients may affect different aspects of your health, from teeth and bones to your heart, gut, muscles, blood pressure, weight, and more.
What is a nutritional shortfall?
Nutritional advice can be confusing. Eat more of this, less of that. Make sure you get enough — but not too much. It’s no wonder many people have so-called nutritional shortfalls, where their diet lacks sufficient essential nutrients.
So, which nutrients do you really need and how much? And what key nutri...
Source: Harvard Health Blog - March 16, 2021 Category: Consumer Health News Authors: Matthew Solan Tags: Health Healthy Eating Nutrition Source Type: blogs
Fight Aging! Newsletter, March 15th 2021
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs.
Tsimane and Moseten Hunter-Gatherers Exhibit Minimal Levels of Atrial Fibrillation
https://www.fightaging.org/archives/2021/03/tsimane-and-moseten-hunter-gatherers-exhibit-minimal-levels-of-atrial-fibrillation/
Epidemiological data for the Tsimane and Moseten populations in Bolivia shows that they suffer very little cardiovascular disease in later life, despite a presumably greater lifetime burden of infectious disease (and consequent inflammation) than is the case for people ...
Source: Fight Aging! - March 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Piperlongumine Reduces Aortic Calcification in Mice
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs. (Source: Fight Aging!)
Source: Fight Aging! - March 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 8th 2021
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-a...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Elastrin Develops a Means to Break Down Calcification of Tissues
Calcification of tissues is one of the mechanisms by which stiffening occurs in the cardiovascular system, leading to a range of increasingly serious downstream consequences. The evidence of recent years suggests that chronic inflammation and the harmful signaling of senescent cells are a major cause of cells in blood vessel walls inappropriately taking on osteoblast-like behavior, depositing calcium into the extracellular matrix as though they are building bone. Among the many other consequences, this process damages the elastin molecules in areas in which it occurs, and the approach taken by biotech startup Elastrin Ther...
Source: Fight Aging! - March 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
