Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exosome Therapy Appears as Effective as Cell Therapy for Cardiac Regeneration
Cells are logistically challenging and more expensive to work with in comparison to components of cell signaling such as proteins or extracellular vesicles. In cell therapies wherein the bulk of the benefit is due to signaling by the transplanted cells - which is the case for near all first generation stem cell therapies, in which the newly introduced cells have a very low survival rate - it makes a lot of sense to isolate the relevant signals and deliver those instead of cells. Since a majority of signaling is transported via classes of extracellular vesicle, such as exosomes, many development programs now focus on the de...
Source: Fight Aging! - September 29, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Aortic and pulmonary vascular abnormalities on CXR
Aortic abnormalities on CXR
Right aortic arch: Side of aortic arch is recognized by the indentation of tracheal air shadow. Normally it is on the left side as it is left aortic arch. In right aortic arch, the indentation is on the right side. Right aortic arch may be seen in tetralogy of Fallot and truncus arteriosus.
Ascending aorta: Ascending aorta is seen well just above the right atrial contour on the right cardiac border when it is dilated. Dilated ascending aorta can occur in:
Post stenotic dilatation in aortic stenosis
Annuloaortic ectasia in Marfan syndrome
Ascending aortic aneurysm
Aortic knuckle: Intimal calci...
Source: Cardiophile MD - September 29, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: HBC 3 sign in coarctation of aorta Antler sign Ascending aorta calcium sign cephalization cottage loaf sign E sign in coarctation of aorta Figure of 8 sign inverted moustache sign knuckle sign Palla’s sign Redistribution Revers Source Type: blogs
Upregulation of Mitophagy as an Approach to Treat Age-Related Disease
Mitophagy is a cellular housekeeping process that removes damaged mitochondria. Mitochondria are the power plants of the cell, crucial in all tissues, but particularly so in the energy-hungry brain and muscles. Mitochondrial function declines with age throughout the body, and failing mitophagy is a proximate contributing cause of this issue, allowing dysfunctional mitochondria to accumulate in cells. Why this happens is a topic for study; various important genes relating to mitochondrial structure and mitophagy have alterations in expression levels, a maladaptive reaction to the damaged environment of aged tissues, perhaps...
Source: Fight Aging! - September 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
" It isn't a STEMI, " so cath lab refusal (again). Were they right?
Sent by Anonymous, written by Pendell MeyersAn elderly female called EMS for acute epigastric pain. EMS arrived and recorded this ECG on the way to the hospital:This case was sent to me with only the details above, and my response was: " It ' s posterolateral (and probably also inferior) OMI until proven otherwise. I ' d also give a little calcium because it ' s slow, wide, and a couple leads have almost pointy Ts. But I don ' t really think it ' s hyperK. This one is OMI. Either LCX or RCA, or perhaps an Obtuse Marginal that supplies those regions. "Interpretation: There is an absence of sinus activity, including an ...
Source: Dr. Smith's ECG Blog - September 27, 2020 Category: Cardiology Authors: Pendell Source Type: blogs
Cardiac action potential
Typically described cardiac action potential is that of the myocardial cell. Action potential of tissues like sinus node will be different and characterized by diastolic depolarization which contributes to the automaticity.
Action potential of the myocardial cell
It may be noted that the cardiac action potential is different from the surface electrocardiogram which represent the sum total of all electrical activity of the heart as recorded from the body surface. Myocardial action potential is recorded with intracellular electrode under experimental conditions. The action potential has a total of 5 phases.
Phase 0 (Rapid d...
Source: Cardiophile MD - September 25, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: HBC Action potential of pacemaker cells Action potential of ventricular myocardial cell diastolic depolarization Funny Current inward rectifier current L-type calcium channels Pacemaker current rapid delayed rectifier current slow delaye Source Type: blogs
Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Higher Temperature Slows Osteoporosis, an Effect Mediated by Polyamine Produced by Gut Microbes
Osteoporosis is the name given to the characteristic age-related loss of bone mass and strength. The extracellular matrix of bone tissue is constantly remodeled, created by osteoblasts and broken down by osteoclasts. The proximate cause of osteoporosis is a tilt in the balance of these processes, favoring osteoclast activity and thus slow loss of bone structure.
Today's research materials discuss a most intriguing result: in mice, maintaining a higher environmental temperature slows the progression of osteoporosis. Interesting, but is it a path to therapy? As is always the case when looking at metabolic responses to...
Source: Fight Aging! - September 18, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Alpha-Ketoglutarate Supplementation Modestly Increases Life Span in Mice
Alpha-ketoglutarate supplementation has been shown to modestly extend life span and improve measures of health in old mice; the publicity materials here accompany the formal release of that paper. Recently, a novel epigenetic clock was used to suggest that alpha-ketoglutarate supplementation in old humans can reduce epigenetic measures of aging, though since this was a novel epigenetic clock, those results should not yet be taken too seriously. Confirming studies are needed, assessing other metrics.
Alpha-ketoglutarate supplementation may act to produce benefits via reductions in excessive inflammatory signaling. Gi...
Source: Fight Aging! - September 15, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Oxygen-Releasing Bioink to Enhance Cell Survival in 3D Printed Structures
Researchers at the Terasaki Institute for Biomedical Innovation in Los Angeles, California have developed an oxygen-releasing bioink that may be useful in 3D printing bioengineered cell constructs. This can help live cells to survive in limited oxygen environments, such as those that exist inside of 3D printed devices, in the first days after implantation.
Heart cells in a bioink (top) without oxygen support and (bottom) with oxygen-releasing capabilities. Live cells are stained green, dead cells in red.
Developing cell-encapsulating constructs, consisting of regenerative cells in a supportive biomaterial matrix, hol...
Source: Medgadget - September 10, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Plastic Surgery Source Type: blogs
Young Man with a Heart Rate of 257. What is it and how to manage?
A 30-something was in the ED for some minor trauma when he was noted to have a fast heart rate. He acknowledged that he had palpitations. but only when asked. He had a history heavy alcohol use. Blood pressure was normal (109/83).Here is his 12-lead:There is a wide complex tachycardia with a rate of 257, with RBBB and LPFB (right axis deviation) morphology.The Differential Diagnosis is: SVT with aberrancy(#) [AVNRT vs. WPW (also called AVRT*)] Atrial flutter with 1:1 conduction, with aberrancy VT coming from the anterior fascicle (fascicular...
Source: Dr. Smith's ECG Blog - September 6, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
A patient with chest pain and ST Elevation in V1 and V2
A 56 year old male complained of chest pain and called 911.They recorded a prehospital ECG:As you can see, at the top it says ***Meet ST Elevation MI Criteria***The medics activated the cath lab prehospital.It is a pathognomonic ECG.What is it?This is hyperkalemia, severe. Surprisingly, there appear to be P-waves, which are often extinguished when the K is so high.Severe hyperkalemia often presents with STE in V1 and V2, often with a Brugada-like morphology (tall R in V1, or rSR ' ; downsloping ST segment; negative T-wave. There is a very wide QRS and very peaked T-waves. Especially in V4 and V5, T-waves ...
Source: Dr. Smith's ECG Blog - September 4, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Moths for chemists #mothsmatter
Cinnabar – named for the red colour of the mineral mercury sulfide
Mother of Pearl – resembling the natural composite material nacre. There are lots of “pearls”
Silver Y – metallic and migratory
Brassy Longhorn – its wings have a metallic sheen
Burnished Brass – resembles a glistening chunk of scorched alloy
Iron Prominent – patina not unlike the colour and timbre of rusty metal
Copper Underwing – copper-coloured hindwings
Brimstone – named for the alchemists’ name for yellow sulfur
Ruby Tiger – tiger moth named for the red aluminium oxide gem
Green Si...
Source: David Bradley Sciencebase - Songs, Snaps, Science - August 26, 2020 Category: Science Authors: David Bradley Tags: Lepidoptera Source Type: blogs
Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
