Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cisd2 in Aging and Exercise
This open access paper provides an overview of Cisd2, one of many genes for which upregulation extends life and improves health in mice. This is potentially mediated by its effects on the cellular maintenance processes of autophagy and on mitochondrial function. It reduces the loss of mitochondrial function that occurs in aging, perhaps through improved removal of damaged mitochondria via mitophagy, but perhaps through other mechanisms. The researchers show that Cisd2 expression is upregulated as a result of exercise, making it plausibly a part of the regulatory system by which the response to exercise can improve health a...
Source: Fight Aging! - December 18, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A woman with near-syncope, bradycardia, and hypotension
Written by Pendell MeyersA 59-year-old woman with diabetes, hypertension, prior stroke, and peripheral vascular disease presented with multiple near-syncopal events over the past 2 days, as well as ongoing back pain. EMS found her bradycardic in the 40s and administered atropine with no response. She was mentating and had a reasonable blood pressure (around 90s systolic), so they decided not to pace prehospital. On arrival the patients blood pressure was 79/50 mm Hg. She was still awake and alert. Here is her first ECG (no baseline available):What do you think?Findings: - junctional bradycardia (no P waves,...
Source: Dr. Smith's ECG Blog - December 18, 2020 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging.
Senescent Cells Fail to Maintain Proteostasis
https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/
Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pl...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Transplantation to Treat Ischemia-Reperfusion Injury: Interview with Dr. Alexander Schueller, CEO of cellvie
The objective of cellvie’s approach is to rescue mitochondria function by the augmentation and replacement of mitochondria, which are damaged during ischemia. Specifically, viable mitochondria are transplanted during reperfusion into the affected cells. Akin to jump-starting a car, the exogenous mitochondria re-invigorate the stunned cells’ energy metabolism, re-enabling them to turn oxygen into energy. It was shown that mitochondria should be freshly isolated to achieve their therapeutic potential. Using cellular or tissue-sources, mitochondria are prepared in an automated system – like a Nespresso machine, mitochon...
Source: Medgadget - December 11, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Critical Care Exclusive Medicine Urology cellvie Source Type: blogs
Relating Warfarin, Vitamin K, and Cellular Senescence in the Progression of Aortic Calcification
Calcification of blood vessel walls progresses with age, an issue that sees cells behave as through they are in bone tissue, a maladaptive reaction to the altered signaling environment and damage of aged tissue. The resulting deposition of calcium makes normally flexible cardiovascular tissue stiff and dysfunctional, ultimately contributing to disease and death. Evidence has accumulated in recent years for the accumulation of senescent cells to be an important contributing factor to calcification. Senescent cells grow in number with age and secrete the senescence-associated secretory phenotype (SASP), signals that rouse th...
Source: Fight Aging! - December 7, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Freezing a Moment in Time: Snapshots of Cryo-EM Research
To get a look at cell components that are too small to see with a normal light microscope, scientists often use cryo-electron microscopy (cryo-EM). As the prefix cryo- means “cold” or “freezing,” cryo-EM involves rapidly freezing a cell, virus, molecular complex, or other structure to prevent water molecules from forming crystals. This preserves the sample in its natural state and keeps it still so that it can be imaged with an electron microscope, which uses beams of electrons instead of light. Some electrons are scattered by the sample, while others pass through it and through magnetic lenses to land on a detecto...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 4, 2020 Category: Research Authors: Chrissa Chverchko Tags: Molecular Structures Tools and Techniques Cellular Imaging Cellular Processes Cool Tools/Techniques Cryo-Electron Microscopy Research Roundup Source Type: blogs
Arrhythmia basics: How often we need to know the mechanism of arrhythmia ?
How many times you have treated cardiac arrhythmia in both emergency & non-emergency situations?
Infinite times.
How many times did you really bother to know the mechanism of a given arrhythmia before ordering medication or shocking?
Hmm,.. let me think. (Except for AVNRT/ AVRT, and few VTs, very rarely I have worried about the mechanism !)
Why is it so? because treatment takes priority and we are able to tame the arrhythmia even without knowing the real mechanism.
The following slide is a gross summary of the cardiac arrhythmia mechanism
Understanding cardiac arrhy...
Source: Dr.S.Venkatesan MD - November 2, 2020 Category: Cardiology Authors: dr s venkatesan Tags: Basic science -Physiology Brugada syndrome cardiac electrophysiology cardiology -Therapeutics Cardiology-Arrhythmias brady dependent vt eads dads early and late after depolarisation enhanced automaticity vs triggerred activity vs reentry Source Type: blogs
Acute Aortic syndrome : Please mind the Length of “ Ascending Aorta ” as well !
Aorta probably is the most critical structure in the entire circulatory system. (apart from the heart of course !) It is a 1.5 to 2.5 mm thick tube, with a diameter of 2.5 cm/length of 30 -35 cm from the aortic valve to the iliac bifurcation.(Eric Borsero 2011) It handles about 7500 liters of blood every day. Understanding the Aortic pathology has vastly improved at the molecular level with deep gene sequencing that defines fibrillin phenotypes. Meanwhile, CT , 4D MRI and 3D prototyping have landed us in a new era where we can feel the exact models of a patient’s virtual aAorta for monitoring and treatment purp...
Source: Dr.S.Venkatesan MD - November 1, 2020 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized marfan aortic dissection aorta size new coconcepts in aortic dimension normal aorta size normal aortic root size what is normal length of ascending aorta Source Type: blogs
Acute Aortic syndrome : Please mind the length of “ Ascending Aorta ” as well.
Aorta probably is the most critical structure in the entire circulatory system. (apart from the heart of course !) It is a 1.5 to 2.5 mm thick tube, with a diameter of 2.5 cm/length of 30 -35 cm from the aortic valve to the iliac bifurcation.(Eric Borsero 2011) It handles about 7500 liters of blood every day. Understanding the Aortic pathology has vastly improved at the molecular level with deep gene sequencing that defines fibrillin phenotypes. Meanwhile, CT , 4D MRI and 3D prototyping have landed us in a new era where we can feel the exact models of a patient’s virtual aAorta for monitoring and treatment purp...
Source: Dr.S.Venkatesan MD - November 1, 2020 Category: Cardiology Authors: dr s venkatesan Tags: aortic aneurysm marfan aortic dissection aorta size new coconcepts in aortic dimension normal aorta size normal aortic root size what is normal length of ascending aorta Source Type: blogs
Fatigue and Weakness and a computer interpretation of STEMI
This case was sent by David Carroll, a 2nd year EM resident, and his attending physician Brad Caloia.A 60-something male presented to the ED with weakness and fatigue. He was diagnosed with a viral syndrome anddischarged. He returned later and had a lab and ECG workup. He had no cardiac history. There was no chest pain or shortness of breath.Here is his ECG:The computer interpretation:Rate: 93 | PR 146 | QRSD 112 | QT/QTc(Bazett) 353/439Normal sinus rhythmAnterolateral infarct, acute / ***ACUTE MI*** What do you think?Dr. Carroll astutely realized something was amiss: what is it?There...
Source: Dr. Smith's ECG Blog - October 30, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What happens if you do not recognize this ECG instantly?
Written by Pendell MeyersA young man in his 20s with history of end stage renal disease and dialysis presented for acute chest pain. His last dialysis was 4 days ago. He was very hypertensive and short of breath, but oxygen saturation was normal.Triage ECG:What do you think?Pathognomonic for severe, life threatening hyperkalemia. QRS widening, PR interval prolongation (I believe those are P waves best seen in V1 and V2, but it matters not), and peaked T waves are apparent. There is also a large R-wave in aVR, which is typical of severe hyperkalemia.Prior ECG on file from 12 days ago:Baseline LVH with repolarization a...
Source: Dr. Smith's ECG Blog - October 21, 2020 Category: Cardiology Authors: Pendell Source Type: blogs
Phosphate as an Agent of Accelerated Aging
Here find an interesting viewpoint on the role of phosphate in mammalian biochemistry, suggesting that it tilts the playing field in the direction of faster degenerative aging. This emerges from work on the longevity-associated gene klotho and its effects on kidney function and vascular function in aging. As is usually the case in such matters, there is no great debate over whether or not specific mechanisms and contributions to aging and age-related diseases exist. The question is whether or not the size of the effect is large enough to care about, and that is always much harder to answer, given the immense complexity of ...
Source: Fight Aging! - October 20, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Amiodarone – class IIIa
Amiodarone is designated as class IIIa antiarrhythmic agent in the Modernized Classification of Cardiac Antiarrhythmic Drugs [1]. This is the group of voltage dependent K+ channel blockers. It is a nonselective K+ channel blocker. Another drug in class IIIa is dronedarone, which is a related drug free of iodine atoms and hence the thyroid related adverse effects of amiodarone.
Amiodarone is useful in wide range of atrial and ventricular arrhythmias and it is a so called broad spectrum antiarrhythmic agent and widely used.
Amiodarone prolongs QTc, but torsades des pointes is rare, possibly due to its effects on other cha...
Source: Cardiophile MD - October 15, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: ECG / Electrophysiology Polysorbate and hypotension with amiodarone Source Type: blogs
