Vitronectin May Contribute to Calcification in Tissues
The interesting research noted here implicates pressure-based changes in the structure of vitronectin as a mediating mechanism linking raised blood pressure and ocular pressure and calcification in tissues. Calcification results from changes in cell behavior that lead to calcium deposition akin to that occurring in bone tissue, but in inappropriate locations such as blood vessel walls. This is disruptive of structure and function, a facet of aging that should be addressed as a part of any comprehensive package of rejuvenation therapies. "Proteins in the blood are under constant and changing pressure because of the...
Source: Fight Aging! - September 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

OCT is not “ Obsessive compulsive tomography ”
This is the story of PCI to LAD from the customary bifurcation workshop for the budding experts, which ended up with a compulsive final OCT run-through, triggering a debate on what to do with the side branch. What shall we do next? Just balloon dilate the distal strut Would consider a second stent. Maybe a TAP  depending upon LCX morphology At this stage, I would like to know the FFR or iFR across LCX Jail. Get rid of this OCT, Let me have look at regular CAG. I bet I can make a better decision. Leave it alone if the clinical status & profile is good Leave it alone? Is it not an incomplete Job? Def...
Source: Dr.S.Venkatesan MD - September 8, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized coronary Imaging ILUMEN study oct opitical coherence tomography Source Type: blogs

Unstable Angina still exists. It can be missed especially high sensitivity troponin is not used. Sometimes you can catch it on the ECG.
A 50-something woman with H/o HTN, ESRD, CAD S/p complex PCI to ostial LAD and ramus (10/2020) and CABG x3 (LIMA to LAD, SVG to OM, SVG to ramus)She complained of intermittent episodes of substernal chest pain, radiating to left shoulder, lasting 2-3 minutes.This had been worked up before at another ED on 3 occasions for the same chest discomfort.--The 1st time, she was " ruled out " with a point of care (POC) troponin <0.03 ng/mL.--The 2nd time, she was " ruled out " again with a POC troponin <0.03 ng/mL.--The 3rd time, she " ruled out " with a laboratory-based 4th generation troponin at 0.018 ng/m...
Source: Dr. Smith's ECG Blog - September 5, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

Generic Crestor Pricing Insanity
For a number of years, I ' ve used a statin drug (like 35 million Americans in the United States do). For more than a few years, these drugs were rather costly and protected by exclusive patent protection, although at the time, they were mostly covered by my insurance to prevent major heart attacks which could cost them even more (hundreds of thousands of dollars in claims).I ' ve used several different low-dose statins over the years, mostly for their preventative benefits. I initially began with Pfizer ' s Lipitor (atorvastatin calcium), but I experienced some pretty severe muscle aches which made it difficult for me to ...
Source: Scott's Web Log - August 23, 2022 Category: Endocrinology Tags: rosuvastatin calcium coupon-generating websites apps coupons Crestor generic generics PBM Source Type: blogs

Very fast narrow complex tachycardia
A 50-something with h/o palpitations, chest pain, and EF of 40% (of unknown etiology) presented with chest pain.Blood pressure, perfusion, and mental status were normal.  Patient was comfortable appearing.  Here is his initial ED ECG:Narrow Complex Tachycardia at a rate of 217AModified Valsalva was attempted without success.Then 6 mg of adenosinewas given.  There was a 2 second interruption, and then this rhythm strip was recorded:  There is now a wide complex, with RBBB pattern.  For unknown reason, the right bundle no longer repolarizes in time for the next beat.  It is r...
Source: Dr. Smith's ECG Blog - August 23, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period. (Source: Fight Aging!)
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

114 Feel Good Quotes to Brighten Your Day and Boost Your Motivation
If you’re going through a bad day or week right now or you just want to start your morning off on the right foot then you’re in the right place. Because in today’s post I’d like to share 114 of the best feel good quotes of all time. Timeless thoughts to help you lift yourself out of negativity and a pessimistic perspective, brighten your day and give you a big boost of motivation right now. So let’s get started. And if you want even more inspiration then check out this post with quotes on progress and this one with hang in there quotes. Uplifting Feel Good Quotes “Just one small positive thought in the morning...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - August 18, 2022 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs

An Alzheimer's Hypothesis Based on Dysfunctional Synaptic Plasticity
The lack of progress towards effective therapies for Alzheimer's disease based on clearance of amyloid-β, and the relentless focus on that goal for the past two decades, has led to a great deal of alternative theorizing about the mechanisms driving the condition. Some of those theories are less well thought of than others, such as the opinion that rising use of common painkillers is the root cause of Alzheimer's. The paper here provides another example of a view of Alzheimer's disease that probably won't gain much traction in the present environment, but is nonetheless an interesting read. The sheer complexity of the agin...
Source: Fight Aging! - August 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Klotho in the Pathology of Aging
Klotho is a longevity-associated protein; more of it slows aging, less of it accelerates aging, at least in animal studies. While researchers have spent considerable effort investigating the effects of klotho on the brain, as it improves cognitive function, it seems likely that its effects arise via improved kidney function in old age. Loss of kidney function, and thus clearance of metabolic toxins and waste from the bloodstream, is harmful to tissues throughout the body. Manipulation of klotho may be a good way to assess just how much harm is generated by the age-related decline of the kidneys. The subject of thi...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A woman in her 40s with intractable nausea and vomiting, dyspnea, and lightheadedness
 Submitted and written by Oriane Longerstaey MD, peer reviewed by Meyers, Smith, and McLarenA woman in her 40s with diabetes and HLD presented with nausea and vomiting x3 days. She was seen on day 1 of symptoms at an outside ED, no ECG performed, and sent home with return precautions and zofran, which she had been taking around the clock for persistent nausea and vomiting. She presented on day 3 of symptoms because of new onset dyspnea, tachycardia, lightheadedness, and heart palpitations. She had a " burning " sensation in her chest but no " pain " .A 12 lead EKG was obtained at triage: - Sinus rhythm at 96 bpm&...
Source: Dr. Smith's ECG Blog - July 21, 2022 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes. Sitting Time Correlates with Mortality Risk https://www.fightaging.org/archi...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Assessing the Causes of Aortic Stiffening in Aged Mice
Aortic stiffness occurs with age, and produces raised blood pressure, hypertension, by sabotaging the usual feedback mechanisms that control blood pressure. Hypertension in turn results in structural damage to delicate tissues throughout the body, as well as producing further biochemical changes that encourage ventricular hypertrophy, among other forms of dysfunction. It causes enough harm that control of blood pressure can meaningfully reduce mortality even without addressing underlying causes of degenerative aging. Why do arteries stiffen with age? As today's open access paper discusses, this is in part a complex ...
Source: Fight Aging! - June 24, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Towards Sabotaging the Link Between Hypertension and Cardiac Hypertrophy
The heart becomes larger and weaker in response to the raised blood pressure of hypertension, though inflammatory signaling clearly also plays an important role. Note the study that showed clearance of senescent cells, and thus removal of their pro-inflammatory signaling, reversed cardiac hypertrophy in mice. In the research noted here, scientists discuss the sensing mechanisms that link blood pressure with hypertrophy of the heart. Sabotaging that system is not as good as prevention of hypertension, as targeting deeper issues should always be better than preventing just a few of their consequences, but will no doubt give ...
Source: Fight Aging! - June 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

An Approach to Reduce Harmful Inflammation in Cardiac Hypertrophy
Chronic inflammation is of great importance in age-related degeneration. In later life, inflammatory signaling becomes constant and unresolved, in contrast to the short-term, rapidly resolved inflammation that occurs in response to infection and injury in youth. This unresolved inflammation is highly disruptive of tissue function and structure. In response to unrelenting inflammatory signaling, cell behaviors change in pathological ways, such as the deposition of calcium into blood vessel walls, or increasing quiescence of stem cells that should be actively supporting tissue. Researchers are in search of ways to sup...
Source: Fight Aging! - June 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs