Vitamin D Deficiency: 6 Common Signs That Are Easy To Miss
Vitamin D is vital for regulating the levels of phosphate and calcium in the body. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 12, 2021 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bradycardia with a Wide Complex. Sometimes 2 pathologies are present. Which?
An elderly woman was found to be bradycardic. She was awake with a BP of 120/70.Here is her prehospital ECG:What do you think?I thought this was likely due to hyperkalemia. I do not see P-waves. It appears to be sinus arrest with ventricular escape. The ST deviations could be ischemia, but are very often the result of hyperkalemia.First ED ECG:Pretty much the sameShe was given multiple doses of Calcium gluconate. 6 grams as I recall. And another ECG was recorded 9 min later:3rd 2.5 hours laterThere are some possible P-waves here, but if they are, there is complete AV block as well, ...
Source: Dr. Smith's ECG Blog - December 12, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
A Trial of Proprietary Epigenetic Age Assessments, With No Other Attached Health Data, Provides No Value
You'll recall that a collection of research groups and companies are working to assess the benefits of alpha-ketoglutarate supplementation. The results reported to date focus exclusively on outcomes in epigenetic age assessment, using a proprietary clock algorithm that is not yet open to inspection or analysis. The open access paper I'll point out today is the formal publication of the results announced earlier this year. Since no other information on patient outcomes beyond epigenetic age is provided - such as, for example, measures of inflammation, immune health, and so forth - this data is essentially of no value whatso...
Source: Fight Aging! - December 8, 2021 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Longevity Gene Cisd2 Improves Liver Function in Aged Mice
Cisd2 is one of the few genes shown to regulate life span in both directions in animal models; less of it shortens life span, while overexpression extends life. Researches here focus on the effects of cisd2 on liver function in mice, showing that maintaining high levels of cisd2 expression into old age beneficially impacts a number of processes implicated in degenerative aging and liver disease. This isn't the only organ in which cisd2 expression has measurable effects; other groups have studied cisd2 in the heart, for example.
The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying l...
Source: Fight Aging! - December 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An Important work in Clinical cardiology : The hidden gem of “ Diamond & Forrester ” !
If anyone asks to shortlist the best papers that were, ever published in clinical cardiology, I am sure, this one will reach the top ten. It was 1979, the field of cardiology is just waiting to explode. CAD was managed primarily with drugs and occasional CABGs. Coronary angiograms were an academic luxury. Both thrombolysis and PCI were unknown. Fortunately, Clinical cardiology was still alive and kicking. Dr. George Diamond and Dr. James Forrester from Cedars Sinai, New York worked together to bring this masterpiece. How and when to suspect CAD in the general population? For the first time probability was app...
Source: Dr.S.Venkatesan MD - December 1, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
A Pathognomonic ECG. What is it? (Hint: 2 diagnoses in one)
I was reading through the list of EKGs and saw this one. What is it diagnostic of? (hint: 2 diagnoses in one)There is a very long, flat, ST segment, resulting in a long QT (most long QT is due to a wide T-wave, not a long ST segment). This is diagnostic of hypocalcemia. There are also peaked T-waves of hyperkalemia. This is a common combination in dialysis patients.The ionized calcium was 2.29 mg/dL (normal is 4.40-5.20). The K was 6.2 mEq/L.Here are the symptoms she had (very typical for hypocalcemia):Dialysis patient with left upper extremity numbness and tingling, lightheadedness, perioral ...
Source: Dr. Smith's ECG Blog - November 29, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wireless Electronic Sensor to Monitor Bone Health
Engineers and orthopedic specialists at the University of Arizona built an ultra-thin wireless sensor that is designed to monitor bone health over long periods of time. The battery-free device is intended to measure a variety of physiological parameters, such as temperature and bone strain, and could be useful for patients with osteoporosis or to monitor healing and guide rehabilitation after a fracture. The device is affixed to the bone surface using a calcium adhesive, which encourages the bone to grow and fuse with the device surface for long-term implantation.
At present, it is difficult to know precisely how a bone...
Source: Medgadget - November 24, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Informatics Materials Orthopedic Surgery osteoporosis uarizona Source Type: blogs
Considering Mechanistic Links Between Vascular Calcification and Osteoporosis
With advancing age, regulatory pathways involved in bone remodeling are activated inappropriately in smooth muscle cells of blood vessel walls and cardiac tissue. The result is calcification of tissue, making it inflexible, and disrupting the normal elasticity. That leads to hypertension and other, worse cardiovascular issues. Inflammatory signaling and the presence of senescent cells appear to be involved in causing this process, but firmly proven chains of cause and effect are yet to be established, as is the case for all too much of the panoply of dysfunctions that arise in the progression of degenerative aging.
...
Source: Fight Aging! - November 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A woman in her 60s with syncope and vomiting. Does she need a pacemaker?
Written by Pendell Meyers with some edits by Steve SmithA woman in her 60s on chemotherapy presented to the Emergency Department for a syncopal episode just prior to arrival. She was walking to the bathroom when she suddenly felt nauseous and passed out. EMS was called by the patient ' s daughter, and en route to the ED she vomited twice. On arrival to the ED, she adamantly denies chest pain but says she ' s " just still not feeling well. " She had no prior known cardiac disease.Triage at 0755:The rhythm is most either atrial fibrillation with complete heart block and resulting junctional escape, or atrial flutter wi...
Source: Dr. Smith's ECG Blog - November 19, 2021 Category: Cardiology Authors: Pendell Source Type: blogs
Toothache, incidental Wide Complex Tachycardia
Discussion by our ElectrophysiologistSmith: “I thought that the wide complex tachy (WCT) could be AVRT or VT” EP: " Antidromic AVRT morphology would essentially be the same as “VT” originating from ventricular the insertion site of the accessory pathway. Therefore, traditional criteria for SVT with aberrancy do not apply to antidromic AVRT (except, that negative concordance can never be AVRT!) " Smith: “But then when the patient converted and had PVCs of exactly the same morphology as the WCT, that it must be VT and not AVRT ” EP: " In cases of intermittent pre-excitation, you cou...
Source: Dr. Smith's ECG Blog - November 17, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Exercise as an Approach to Slow Alzheimer's Disease
Exercise is beneficial at every age, but most people do not undertake enough physical activity. In a sedentary world, structured exercise programs look like a decent therapy, because that exercise corrects a harmful deficiency in the operation of metabolism. Thus the studies showing a reduction in mortality resulting from exercise as an intervention in older individuals. Exercise improves mitochondrial function, amongst other changes, and these changes should be expected to modestly slow the progression of many age-related diseases.
Neurons are highly specialized post-mitotic cells that are inherently dependent on...
Source: Fight Aging! - November 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How We Wrested Control of Our Rx Drug Spending. Maybe You Can, too.
This week, we ' ve heard reporting that the big Congressional bill which was supposed to include a provision for Medicare, which is the taxpayer-funded senior insurance plan to actually negotiate prices on prescription drugs (just as most other countries, as well as the Veteran ' s Administration [VA] already do right now) was going to be omitted because of a handful of PhRMA-bankrolled lawmakers pushed to kill it. That said, it isn ' t over until its over. Although we don ' t know what she might or might not do, House Majority Leader Nancy Pelosi still has some tricks in her own playbook if it doesn ' t happen a...
Source: Scott's Web Log - November 1, 2021 Category: Endocrinology Tags: coupon-generating websites apps PBM prescriptions Source Type: blogs
