Tendril extract of Cucurbita moschata suppresses NLRP3 inflammasome activation in murine macrophages and human trophoblast cells.
In this study, we investigated the effects of hot water extract derived from the tendrils of C. moschata Duchesne (TCMD) on NLRP3 inflammasome activation in murine macrophages and human trophoblast cells. The TCMD treatment of LPS-primed bone marrow-derived macrophages (BMDMs) and human trophoblast cells attenuated NLRP3 inflammasome activation induced by inflammasome activators such as ATP, nigericin, and monosodium urate (MSU). TCMD treatment suppressed IL-1β secretion in a dose-dependent manner, without affecting IL-6 secretion. In addition, TCMD inhibited NLRP3-dependent pyroptosis in BMDMs. TCMD also suppressed the r...
Source: International Journal of Medical Sciences - May 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Metabolic and transcriptomic analysis of two Cucurbita moschata germplasms throughout fruit development
Pumpkins (Cucurbita moschata; Cucurbitaceae) are valued for their fruits and seeds and are rich in nutrients. Carotenoids and sugar contents, as main feature of pumpkin pulp, are used to determine the fruit quali... (Source: BMC Genomics)
Source: BMC Genomics - May 15, 2020 Category: Genetics & Stem Cells Authors: Hafiz Muhammad Khalid Abbas, He-Xun Huang, An-Jun Wang, Ting-Quan Wu, Shu-Dan Xue, Aqeel Ahmad, Da-Sen Xie, Jun-Xing Li and Yu-Juan Zhong Tags: Research article Source Type: research
Complex coacervation of acid-extracted fiber from butternut squash (Cucurbita moschata) and protein
Publication date: Available online 8 May 2020Source: Food HydrocolloidsAuthor(s): Maja M. Milošević, Tatjana R. Đorđević, Mirjana G. Antov (Source: Food Hydrocolloids)
Source: Food Hydrocolloids - May 9, 2020 Category: Food Science Source Type: research
Molecules, Vol. 25, Pages 2077: New 8-C-p-Hydroxylbenzylflavonol Glycosides from Pumpkin (Cucurbita moschata Duch.) Tendril and Their Osteoclast Differentiation Inhibitory Activities
Jeong-Yong Cho
Six new 8-C-p-hydroxybenzylflavonol glycosides were isolated from a hot water extract of pumpkin (Cucurbita moschata Duch.) tendril and elucidated as 8-C-p-hydroxybenzylquercetin 3-O-rutinoside, 8-C-p-hydroxybenzoylquercetin 3-O-β-D-glucopyranoside, 8-C-p-hydroxybenzylkaempferol 3-O-(α-L-rhamnopyranosyl(1→6)-β-D-galactopyranoside, 8-C-p-hydroxybenzoylkaempferol 3-O-rutinoside, 8-C-p-hydroxybenzylisorhamnetin 3-O-rutinoside, and 8-C-p-hydroxybenzylisorhamnetin 3-O-(α-L-rhamnopyranosyl(1→6)-β-D-galactopyranoside. ...
Source: Molecules - April 28, 2020 Category: Chemistry Authors: Kiok Kim Joo-Hee Choi Jisu Oh Ji-Yeon Park Young-Min Kim Jae-Hak Moon Jong-Hwan Park Jeong-Yong Cho Tags: Article Source Type: research
Molecules, Vol. 25, Pages 1699: Aggregation and Molecular Properties of β-Glucosidase Isoform II in Chayote (Sechium edule)
Pineda
Aymara Judith Díaz Barrita
Edgar Zenteno
Carlos Romero Díaz
Ruth Martínez Cruz
Eduardo Pérez-Campos Mayoral
Edith Alhelí Bernabé Pérez
Alma Dolores Pérez Santiago
María del Socorro Pina-Canseco
Margarito Martínez Cruz
The presence of isoforms of β-glucosidase has been reported in some grasses such as sorghum, rice and maize. This work aims to extract and characterize isoform II in β-glucosidase from S. edule. A crude extract was prepared without buffer solution and adjusted to pH 4.6. Contaminating proteins were precipitated at 4 °C for 24 h. The ...
Source: Molecules - April 7, 2020 Category: Chemistry Authors: Alberto Cruz Rodr íguez Fabiola Anaid S ánchez Esperanza Eduardo P érez-Campos Mar ía Teresa Hernández-Huerta Laura P érez-Campos Mayoral Carlos Alberto Matias-Cervantes Alexis Mart ínez Barras Gabriel Mayoral-Andrade Luis Ángel Santos Pineda Ayma Tags: Article Source Type: research
Water extract of tendril of Cucurbita Moschata Duch. suppresses RANKL-induced osteoclastogenesis by down-regulating p38 and ERK signaling.
Conclusion: These findings suggest that TCMD may have preventive and therapeutic effects for destructive bone diseases.
PMID: 32210713 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 28, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Rheological and physico-chemical properties of milk gel using isolate of pumpkin (Cucurbita moschata) seeds: A new source of milk clotting peptidase
Publication date: Available online 18 March 2020Source: Food HydrocolloidsAuthor(s): Abhiraman Kumar, Soumya Sasmal (Source: Food Hydrocolloids)
Source: Food Hydrocolloids - March 19, 2020 Category: Food Science Source Type: research
Quantification of the Antioxidants and Assessment of the Antioxidant Activity of Two Cucurbita Species Harvested in Bejaia (Algeria)
Conclusion: The richness of Cucurbita species in antioxidants allows them to be used in different industries including agri-food to protect from oxidation. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - February 18, 2020 Category: Nutrition Source Type: research
Quantification of the Antioxidants and Assessment of the Antioxidant Activity of Two Cucurbita Species Harvested in Bejaia (Algeria)
Conclusion: The richness of Cucurbita species in antioxidants allows them to be used in different industries including agri-food to protect from oxidation. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - February 14, 2020 Category: Nutrition Source Type: research
Nutritional characterization of Butternut squash (Cucurbita moschata D.): Effect of variety (Ariel vs. Pluto) and farming type (conventional vs. organic)
Publication date: Available online 3 February 2020Source: Food Research InternationalAuthor(s): Jorge Armesto, Gabriele Rocchetti, Biancamaria Senizza, Mirian Pateiro, Francisco J. Barba, Rubén Domínguez, Luigi Lucini, José M. LorenzoAbstractFarming systems and cultivar types are two of the main factors able to affect the nutritional quality of plant foods for human nutrition. Therefore, the aim of this study was to compare the impact of two unexplored variety (namely Ariel and Pluto) and farming type (conventional and organic) on physicochemical parameters, chemical and mineral composition, water- and fat-soluble vitam...
Source: Food Research International - February 7, 2020 Category: Food Science Source Type: research
Green synthesis of iron oxide nanoparticles for tartrazine and bordeaux red dye removal
Publication date: Available online 17 December 2019Source: Journal of Environmental Chemical EngineeringAuthor(s): Ana Carolina de Lima Barizão, Marcela Fernandes Silva, Murilo Andrade, Fernanda Caroline Brito, Raquel Guttierres Gomes, Rosângela BergamascoAbstractDyes are widely used industrially to make various products more attractive to consumers. However, this class of compounds is usually not removed by common effluent treatments, generating a pollutant load. In this context, this work aimed at the application of two samples of iron oxide nanoparticles (NPsFeO) obtained through a green synthesis method using two agr...
Source: Journal of Environmental Chemical Engineering - December 18, 2019 Category: Chemistry Source Type: research
Construction and biological characterization of an Agrobacterium-mediated infectious cDNA of squash mosaic virus.
Abstract
Squash mosaic virus (SqMV), a member of the species Squash mosaic virus in the genus Comovirus (family Comoviridae), is an important seed-borne virus that causes serious economic losses in cucurbit crops. Here, we constructed infectious cDNA clones of SqMV genomic RNAs (RNA1 and RNA2) under the control of the cauliflower mosaic virus (CaMV) 35S promoter by Gibson assembly. The infectious cDNA clones of SqMV could infect zucchini squash (Cucurbita pepo) plants systemically by agrobacterium-mediated inoculation. The virus progeny from the infectious clones showed no difference from the wild type in ...
Source: Virus Research - September 23, 2019 Category: Virology Authors: Liu L, Xie K, Tsekpuia AR, Peng B, Liu M, Gu Q Tags: Virus Res Source Type: research
Molecules, Vol. 24, Pages 2945: The Profile of Secondary Metabolites and Other Bioactive Compounds in Cucurbita pepo L. and Cucurbita moschata Pumpkin Cultivars
a
Plants and animals are sources of various bioactive compounds that exhibit a broad spectrum of health-promoting effects. Scientists continue studies on the chemical composition of many products in search of foods with high nutritional value. The pumpkin (Cucurbita sp.) is unquestionably a source of valuable nutrients. This vegetable is well-known all over the world and it is appreciated due to its high content of carotenoids, but it is still not much used in the processing industry. The aim of present study was to compare the flesh of 15 pumpkin varieties belonging to the Cucurbita pepo and C. moschata species in ter...
Source: Molecules - August 13, 2019 Category: Chemistry Authors: Bartosz Kulczy ński Anna Gramza-Micha łowska Tags: Article Source Type: research
Autophagy flux modulation by a carotenoid-enriched extract from the pumpkin Cucurbita moschata on human chronic lymphocytic leukemia cell line
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Maria Russo, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Carmen Cervellera, Gian Luigi Russo (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - July 20, 2019 Category: Nutrition Source Type: research
Autophagy flux modulation by a carotenoid-enriched extract from the pumpkin Cucurbita moschata on human chronic lymphocytic leukemia cell line
Introduction: Chronic lymphocytic leukemia (CLL) is the most frequent form of leukemia in adult population and chemotherapy resistance occurs in 15 –30% of patients with elevated genomic complexity. Apoptosis resistance and induction of a protective form of autophagy are possible explanations of the poor responsivity of CLL to conventional and novel therapeutic drugs. Given the difficulties to maintain in culture B-CLL lymphocytes, the HG3 ce ll line represents an interesting preclinical model to study the effects of natural bioactive molecules or extracts derived from food matrix as potential, chemo-sensitizers in CLL. ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Maria Russo, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Carmen Cervellera, Gian Luigi Russo Source Type: research
