Autophagy flux modulation by a carotenoid-enriched extract from the pumpkin Cucurbita moschata on human chronic lymphocytic leukemia cell line
Introduction: Chronic lymphocytic leukemia (CLL) is the most frequent form of leukemia in adult population and chemotherapy resistance occurs in 15 –30% of patients with elevated genomic complexity. Apoptosis resistance and induction of a protective form of autophagy are possible explanations of the poor responsivity of CLL to conventional and novel therapeutic drugs. Given the difficulties to maintain in culture B-CLL lymphocytes, the HG3 ce ll line represents an interesting preclinical model to study the effects of natural bioactive molecules or extracts derived from food matrix as potential, chemo-sensitizers in CLL.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Maria Russo, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Carmen Cervellera, Gian Luigi Russo Source Type: research
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