Efficacy and safety of co-trimoxazole in eradication phase of melioidosis; systematic review
Melioidosis is an infectious disease caused by the bacterium Burkholderia pseudomallei. The two stages of melioidosis treatment are the intense intravenous phase and the oral eradication phase. Although co-trimox... (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - August 17, 2023 Category: Microbiology Authors: Keragala Arachchige Reshani Kaumada Keragala, Maththe Gama Ralalage Shobha Sanjeewani Gunathilaka, Rathnabahu Mudiyanselage Indika Sanjeewa Kumara Senevirathna and Jayaweera Arachchige Asela Sampath Jayaweera Tags: Review Source Type: research
Intranasal immunization with a Bucl8-based vaccine ameliorates bacterial burden and pathological inflammation, and promotes an IgG2a/b dominant response in an outbred mouse model of Burkholderia infection
In this study, we hypothesized that an intranasally administered L1-CRM197 vaccine would induce protective mucosal immunity. To evaluate vaccine efficacy, we developed a surrogate Burkholderia infection model that employs outbred CD-1 mice which imitates the immunogenetic diversity of humans. Mice were immunized with either L1-CRM197 adjuvanted with fluorinated cyclic diguanosine monophosphate (FCDG) or with FCDG-only control. These mice were then challenged intranasally with an infectious dose of a luminescent strain of B. thailandensis E264 two weeks post-immunization, and correlates of protection were assessed in euthan...
Source: Frontiers in Immunology - July 20, 2023 Category: Allergy & Immunology Source Type: research
[ASAP] Analysis of Structure –Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of < named-content content-type="genus-species" xlink:type="simple" > Neisseria meningitidis < /named-content > , < named-content content-type="genus-species" xlink:type="simple" > Neisseria gonorrhoeae < /named-content > , and < named-content content-type="genus-species" xlink:type="simple" > Burkholderia pseudomallei < /named-content >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00458 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 30, 2023 Category: Chemistry Authors: Nicolas J. Scheuplein, Nicole M. Bzdyl, Theresa Lohr, Emily A. Kibble, Anja Hasenkopf, Carina Herbst, Mitali Sarkar-Tyson, and Ulrike Holzgrabe Source Type: research
Rational design of an acidic erythritol (ACER) medium for the enhanced isolation of the environmental pathogen Burkholderia pseudomallei from soil samples
In conclusion, our newly developed ACER medium significantly improves the isolation of viable B. pseudomallei from soils and, thereby, has the potential to reduce the rate of false-negative environmental cultures in melioidosis risk areas. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - June 30, 2023 Category: Microbiology Source Type: research
Epidemiology of Pathogens Listed as Potential Bioterrorism Agents, the Netherlands, 2009 ‒2019
Emerg Infect Dis. 2023 Jul;29(7):1-9. doi: 10.3201/eid2907.221769.ABSTRACTWe provide incidences (cases/10 million persons) in the Netherlands during 2009-2019 for pathogens listed as potential bioterrorism agents. We included pathogens from the highest categories of the European Medicines Agency or the US Centers for Disease Control and Prevention. Notifiable diseases and recently published data were used to calculate the average annual incidence. Coxiella burnetii had the highest incidence because of a Q fever epidemic during 2007-2010. Incidence then decreased to 10.8 cases/. Pathogens with an incidence >1 were Brucel...
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Jorrit Broertjes Eelco Franz Ingrid H M Friesema Hugo-Jan Jansen Frans A G Reubsaet Saskia A Rutjes Cornelis Stijnis Bettie C G Voordouw Maaike C de Vries Daan W Notermans Martin P Grobusch Source Type: research
Epidemiology of Pathogens Listed as Potential Bioterrorism Agents, the Netherlands, 2009 ‒2019
Emerg Infect Dis. 2023 Jul;29(7):1-9. doi: 10.3201/eid2907.221769.ABSTRACTWe provide incidences (cases/10 million persons) in the Netherlands during 2009-2019 for pathogens listed as potential bioterrorism agents. We included pathogens from the highest categories of the European Medicines Agency or the US Centers for Disease Control and Prevention. Notifiable diseases and recently published data were used to calculate the average annual incidence. Coxiella burnetii had the highest incidence because of a Q fever epidemic during 2007-2010. Incidence then decreased to 10.8 cases/. Pathogens with an incidence >1 were Brucel...
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Jorrit Broertjes Eelco Franz Ingrid H M Friesema Hugo-Jan Jansen Frans A G Reubsaet Saskia A Rutjes Cornelis Stijnis Bettie C G Voordouw Maaike C de Vries Daan W Notermans Martin P Grobusch Source Type: research
Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities in Burkholderia thailandensis E264
This study provides evidence that QS is of prime interest when it comes to understanding the virulence of Burkholderia species and developing alternative treatments. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - June 2, 2023 Category: Microbiology Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: The American Journal of Tropical Medicine and Hygiene - May 15, 2023 Category: Tropical Medicine Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: The American Journal of Tropical Medicine and Hygiene - May 15, 2023 Category: Tropical Medicine Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: The American Journal of Tropical Medicine and Hygiene - May 15, 2023 Category: Tropical Medicine Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: The American Journal of Tropical Medicine and Hygiene - May 15, 2023 Category: Tropical Medicine Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
