Host cell fusion in bacteria infection alarms immune system, causing host cell destruction
(National University of Singapore, Yong Loo Lin School of Medicine) NUS Medicine researchers have identified a new trigger for our immune system--abnormal fusion of host cells to form giant cells after infection by pathogens such as the bacterium Burkholderia pseudomallei. Cell fusion triggered the cGAS-STING pathway, activating a type 1 interferon response which kills pathogens. In extensive cell fusion, cGAS-STING caused the giant cells to self-destruct instead. Since the DNA in the giant cells was damaged, self-destruction likely prevents these cells from becoming cancerous. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2020 Category: Cancer & Oncology Source Type: news

UCLA-led research reveals potential treatments for deadly tropical disease
Melioidosis is a tropical disease that claims an estimated 90,000 lives worldwide each year. There is no vaccine, and current treatments are hampered by the ability of the bacterium that causes the disease to resist even the strongest antibiotics.Hardy and lethal, that bacterium, Burkholderia pseudomallei, is classified by the Centers for Disease Control and Prevention as a potential bioweapon.UCLA-led research has identified two compounds that, based on tests on human cells and on mice, show potential for treating melioidosis. One is a widely used drug already approved by the U.S. Food and Drug Administration as an antifu...
Source: UCLA Newsroom: Health Sciences - September 11, 2019 Category: Universities & Medical Training Source Type: news

SURVEILLANCE SUMMARIES: Melioidosis Cases and Selected Reports of Occupational Exposures to Burkholderia pseudomallei — United States, 2008–2013
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - July 3, 2015 Category: American Health Source Type: news

Escape of dangerous bacterium leads to halt of risky studies at Tulane
Leak of Burkholderia pseudomallei has led to intense search for source, newspaper reports (Source: ScienceNOW)
Source: ScienceNOW - March 2, 2015 Category: Science Source Type: news

Letter to the Editors
In the article entitled “Sniff the Plates? Laboratory Exposure to Burkholderia pseudomallei” in the February 15, 2013 issue of Clinical Microbiology Newsletter (CMN Vol. 35, No. 4), Knost et al. () reported a case of melioidosis in a 27-year-old-male. After reading the article, we note the need for a number of clarifications that we would like to bring to the attention of the CMN readership. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - April 28, 2014 Category: Microbiology Authors: Tina J. Benoit, David D. Blaney Tags: Letter to the Editors Source Type: news

Sniff the Plates? Laboratory Exposure to Burkholderia pseudomallei
We report a case of melioidosis in a 27-year-old male who presented with localized neck swelling and later developed complications due to the patient's non-compliance with his antibiotic therapy. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - February 6, 2013 Category: Microbiology Authors: S. Knost, M.C. Marroum, T. Nozar, L. Tagle, J. Horton, L.W. Raymond, J. Kase, S. Kilpatrick, W. Boehringer, A.Y. Peng, R.L. Sautter Source Type: news