Isolation of Burkholderia pseudomallei from a goat in New Caledonia: implications for animal and human health monitoring and serological tool comparison
Melioidosis is a serious bacterial infection caused by Burkholderia pseudomallei, a gram-negative bacterium commonly found in soil and water. It can affect both humans and animals, and is endemic in regions such ... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 23, 2024 Category: Veterinary Research Authors: Anais Desoutter, Thomas Deshayes, Fabien Vorimore, Bernice Klotoe, Benoit Durand, Julien Colot, Gabriel Wagner-Lichtenegger, Ivo Steinmetz, Apichai Tuanyok and Karine Laroucau Tags: Research Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Burkholderia pseudomallei Bacteria in Ornamental Fish Tanks, Vientiane, Laos, 2023
Emerg Infect Dis. 2024 Mar;30(3):599-600. doi: 10.3201/eid3003.231674.ABSTRACTIn 2019, a melioidosis case in Maryland, USA, was shown to have been acquired from an ornamental fish tank contaminated with Burkholderia pseudomallei bacteria, likely derived from Southeast Asia. We investigated the presence of B. pseudomallei in ornamental fish tanks in the endemic area of Vientiane, Laos.PMID:38407187 | DOI:10.3201/eid3003.231674 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Tim Venkatesan Vannavong Siritana Joy Silisouk Tamalee Roberts Matthew T Robinson David A B Dance Source Type: research
Burkholderia pseudomallei Bacteria in Ornamental Fish Tanks, Vientiane, Laos, 2023
Emerg Infect Dis. 2024 Mar;30(3):599-600. doi: 10.3201/eid3003.231674.ABSTRACTIn 2019, a melioidosis case in Maryland, USA, was shown to have been acquired from an ornamental fish tank contaminated with Burkholderia pseudomallei bacteria, likely derived from Southeast Asia. We investigated the presence of B. pseudomallei in ornamental fish tanks in the endemic area of Vientiane, Laos.PMID:38407187 | DOI:10.3201/eid3003.231674 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Tim Venkatesan Vannavong Siritana Joy Silisouk Tamalee Roberts Matthew T Robinson David A B Dance Source Type: research
Function of Burkholderia pseudomallei RpoS and RpoN2 in bacterial invasion, intracellular survival, and multinucleated giant cell formation in mouse macrophage cell line
In this study, by using the mouse macrophage cell line RAW264.7 as a model of infection, the involvement of B. pseudomallei RpoS and RpoN2 in the invasion, intracellular survival leading to the reduction in multinucleated giant cell (MNGC) formation of RAW264.7 cell line were illustrated. We have demonstrated that the MNGC formation of RAW264.7 cell was dependent on a certain number of intracellular bacteria (at least 5 × 104). In addition, the same MNGC formation (15%) observed in RAW264.7 cells infected with either B. pseudomallei wild type with multiplicity of infection (MOI) 2 or RpoN2 mutant (∆rpoN2) with MOI 10 or...
Source: Antonie van Leeuwenhoek - February 23, 2024 Category: Microbiology Authors: Duong Thi Hong Diep Long Binh Vong Sumalee Tungpradabkul Source Type: research
Management of unexpected laboratory exposure to Burkholderia pseudomallei
We report here a couple of microbiological arguments that can usually guide microbiologists towards presumptive identification of B. pseudomallei. This case report shows the importance of MALDI-TOF MS accurate databases to ensure accurate microbial identification and antibiotic prophylaxis adapted to individuals who were exposed. We also want to underline the importance of developing an effective strategy of prevention against any accidental exposure that can occur in a microbiological laboratory.PMID:38391168 | DOI:10.1684/abc.2023.1854 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - February 23, 2024 Category: Biochemistry Authors: Imane Mostaghat Carine Couzigou Beno ît Pilmis Nathalie Castreau Eric Raymond Anne-Lise Maixant Alban Le Monnier Anne Depeille Olivier Gorg é Assaf Mizrahi Source Type: research
