The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei
Copper radical oxidases (CROs) from Auxiliary Activities family 5 can oxidize various alcohol substrates. Bacterial CROs are less studied than eukaryotic enzymes. Here we have characterized an unusual bacterial CRO that acts only on primary alcohols and is fused to a carbohydrate esterase domain, which was completely inactive due to substitutions of key amino acid residues in the active site. Copper radical oxidases (CROs) are redox enzymes able to oxidize alcohols or aldehydes, while only requiring a single copper atom as cofactor. Studied CROs are found in one of two subfamilies within the Auxiliary Activities family 5 (...
Source: FEBS Letters - May 5, 2023 Category: Biochemistry Authors: Scott Mazurkewich,
Andrea Seveso,
Johan Larsbrink Tags: Research Letter Source Type: research
Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
Antimicrob Agents Chemother. 2023 May 3:e0017123. doi: 10.1128/aac.00171-23. Online ahead of print.ABSTRACTCefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsu...
Source: Antimicrobial Agents and Chemotherapy - May 3, 2023 Category: Microbiology Authors: Carina M Hall Nawarat Somprasong Johannah P Hagen Roxanne Nottingham Jason W Sahl Jessica R Webb Mark Mayo Bart J Currie Yuwana Podin David M Wagner Paul Keim Herbert P Schweizer Source Type: research
Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
Antimicrob Agents Chemother. 2023 May 3:e0017123. doi: 10.1128/aac.00171-23. Online ahead of print.ABSTRACTCefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsu...
Source: Antimicrobial Agents and Chemotherapy - May 3, 2023 Category: Microbiology Authors: Carina M Hall Nawarat Somprasong Johannah P Hagen Roxanne Nottingham Jason W Sahl Jessica R Webb Mark Mayo Bart J Currie Yuwana Podin David M Wagner Paul Keim Herbert P Schweizer Source Type: research
